摘要:

The influence of urea on the percutaneous permeation under different conditions of application and on the epidermal effectiveness of 5-fluorouracil (FU) as an example for water-soluble agents is reported. The proceedings of permeation of FU are accelerated by admixture of, or pretreatment with, urea and by increasing the hydration of the horny layer by pretreatment with NaCl. The effectiveness of FU on the epidermis is increased simultaneously. However, the permeation rate of FU is decreased by pretreatment with HTH® as an example of a stabilized urea emulsion; on the other hand, the most favourable therapeutic effect is demonstrable. Therefore, the permeation of an agent may be both enhanced and inhibited by different modes of urea application. These findings appear to be important for both the optimization of topical treatment and the industrial medicine’s point of vi

ISSN:1018-8665    

DOI:10.1159/000250655

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

2 patients with long-standing and wide-spread pityriasis lichenoides chronica were treated with orally administered 8-methoxypsoralen and UVA irradiation (PUVA therapy). After 15–21 PUVA treatments the patients were completely cleared. 3 and 4 weeks after the initial PUVA treatment, phase recurrences occurred in both patients. In 1 patient the lesions appeared clinically and histologically as pityriasis lichenoides et varioliformis acut

ISSN:1018-8665    

DOI:10.1159/000250656

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

2 patients with Sézary syndrome were treated with levamisole. Both patients had clinical and hematological evidence of acceleration of their disease and ultimately died, although 1 patient had improvement in skin test reactivity. We suggest that levamisole be used with caution, if at all, in patients with T-lymphocyte malignancies

ISSN:1018-8665    

DOI:10.1159/000250657

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

In a double-blind randomized comparative multicenter trial, consisting of 29 patients with acne vulgaris who were unable to tolerate daily applications of retinoic acid, the retinoic acid derivative Ro 11–1430 (0.1% vanishing cream) was compared in a 6–8 weeks topical treatment with vanishing cream alone (placebo). Regarding efficacy, for most criteria measured the response was always better with Ro 11–1430 than with placebo, although the differences were not always statistically significant for several reasons, one probably being the small number of patients in the trial. Regarding tolerance, both treatments were satisfactory. Ro 11–1430 and placebo did not differ significantly regarding frequency and severity of erythema, desquamation and burning. These results suggest that treatment with Ro 11–1430 should be considered in acne patients who are unable to use retinoic acid due to severe local

ISSN:1018-8665    

DOI:10.1159/000250658

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

A case of generalized eruptive histiocytoma in a 52-year-old Indian male is described. This is probably the tenth case in the world and the first from this country. Histopathological features are discussed in detail and the literature is reviewed.

ISSN:1018-8665    

DOI:10.1159/000250659

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

3 cases of cutaneous vegetant intravascular hemangioendothelioma are presented, 2 of them corresponded to a pure form, whilst the other arose in a pyogenic granuloma. All lesions behaved in a benign fashion. In some cases these may mimic an angiosarcoma (Masson’s pseudoangiosarcoma). The endothelial proliferation, which characterizes the lesion, is considered as a reactive phenomenon secondary to fibrin deposits originating from the destruction of the vascular walls of a hemangiom

ISSN:1018-8665    

DOI:10.1159/000250660

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

Eosinophilic fasciitis is an additional clinical entity to many others manifested by sclerodermic changes in the skin. A case with this process is reported. It presents vast cutaneous sclerodermic changes associated with eosinophilia, signs of muscular exertion, and a massive inflammatory infiltrate involving the lower part of the dermis, subcutaneous tissue and the muscle fascia. Prednisone therapy was followed by rapid and marked improvement.

ISSN:1018-8665    

DOI:10.1159/000250661

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

Clinical and ultrastructural study of three cases of acquired nevoid telangiectasia: (1) angioma serpiginosum, (2) angiokeratoma neviformis, and (3) unilateral nevoid telangiectasia. Despite the clinical similarities, the ultrastructural aspects of these lesions are different, showing: (1) ectasia of arteriolar type, (2) budding of capillaries, and (3) ectasia of venular type. The physiopathological mechanism of these lesions seems to be different.

ISSN:1018-8665    

DOI:10.1159/000250662

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

A case of multiple neonatal haemangiomatosis is reported. The disease entity is rare and probably always combined with haemangiomas of internal organs. When visceral involvement provokes clinical symptoms (cardiac, cerebral, gastrointestinal), the spontaneous course often proves fatal. The prognosis seems to improve substantially if treatment with systemic corticosteroids is instituted. The patient reported, who had concomitant cardiac and gastrointestinal symptoms, recovered completely following corticosteroid treatment. It is concluded that steroid treatment is indicated without hazards in complicated cases of multiple neonatal haemangiomatosis.

ISSN:1018-8665    

DOI:10.1159/000250663

出版商:S. Karger AG    

年代:1979

数据来源: Karger

ISSN:1018-8665    

DOI:10.1159/000250664

出版商:S. Karger AG    

年代:1979

数据来源: Karger