摘要:

New knowledge of the function and biological behaviour of the cells of the lymphocytic system justifies a critical reappraisal of the nature and origin of mycosis fungoides (MF). The fact that in MF the immune response remains active during the whole course of the disease distinguishes it from other malignant processes. On the basis of the well-known fact that chronic stimulation of the immunological system may lead to tumour formation, the hypothesis is stressed that MF may be an ‘immunocytoma’ or ‘immunoma’. New findings indicate that immunological stimulation of lymphocytes may lead to the formation of endogenous oncogenic viruses. All these questions should be investigated in as many centres as p

ISSN:1018-8665    

DOI:10.1159/000251100

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

In an attempt to correlate the presence of subepidermal and renal glomerular deposits in murine lupus, skin and kidney tissue from 67 (NZB × W)F1 mice was examined by direct immunofluorescence and the results tabulated. Between 36 and 43 weeks of age, deposits in both locations were detected in only 50.5% of the mice, and between 44 and 52 weeks, in only 79.0%. The titer of antibody to DNA did not correlate with the presence of subepidermal deposits even though DNA was demonstrated at the epidermal-dermal interface. It is concluded that the absence of immunoglobulin in the subepidermis does not preclude the presence of renal deposits, and it is hazardous to attempt to predict underlying glomerular deposition by performing immunofluorescence examination of skin in murine lupus

ISSN:1018-8665    

DOI:10.1159/000251101

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

Econazole is a broad-spectrum antimicrobic substance which acts by permeabilizing the cell membranes. Glucocorticoids by their surface activity may counteract this effect by protecting the cell membranes. In fact, a protective action of glucocorticoids in high concentrations against econazole nitrate could be demonstrated in yeasts, not in staphylococci. The techniques applied were the Warburg assays (resting yeasts, resting and proliferating bacteria). The elicitation of a blanching reaction on human skin by triamcinolone acetonide was not altered in the presence of econazole nitrate. The data collected in this study were discussed in regard to the combined use of antimicrobic drugs and glucocorticoids in topical therapy.

ISSN:1018-8665    

DOI:10.1159/000251102

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

Numerous skin lesions: sebaceous hyperplasias, benign acanthoma, keratoacanthomas and squamous cell epitheliomas appeared on the face, especially on the nose, on the cheeks and around the lips of a 45-year-old obese man with mild diabetes. In 1969, an adenocarcinoma had been found in the rectosigmoid and another one in the colon. In 1974, an excision of a well-differenciated epidermoid carcinoma was performed in the right external auditory meatus. A rectoscopy showed a micropolyp at the rectosigmoid junction. In 1975, an abdominal exploration was performed following a sudden relapse of about 50 skin lesions in the face, partly sebaceous adenomas, partly sebaceous gland épithéliomas, and about 10 precancerous lesions on the dorsum of the hands. A villous adenoma of the colon was removed. Inheritance appears to the autosomal dominant with variability in the expressiveness of the cutaneo-intestinal symptom

ISSN:1018-8665    

DOI:10.1159/000251103

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

Aspects of lymphocyte function were investigated, in vitro, in nine patients with active Behçet’s disease. The rosette formation technique revealed a slight decrease in number of T lymphocytes and more so of B lymphocytes. In spite of their low number, the transformation of the T lymphocytes in response to mitogens did not show a significant difference from that of normal controls. This may indicate a hyperreactivity, and in two instances a spontaneous blastogenesis prior to addition of mitogens, was also noted. The immunoglobulins and complement levels in serum were within normal limi

ISSN:1018-8665    

DOI:10.1159/000251104

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

30 patients with multiple types of sunlight sensitivity were treated successfully with DHA/lawsone sunscreen. This sunscreen was able to protect all patients even though their photosensitivities were in different parts of the ultraviolet and visible spectrum. About 80% of the patients experienced sufficient protection during the summer months to lead a virtually normal life-style while participating in all kinds of outdoor activities.

ISSN:1018-8665    

DOI:10.1159/000251105

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

Two cases with pyoderma gangrenosum are presented. The course, in both cases, suggested that immunosuppressive therapy may play an etiological role in the disease. The first was a kidney recipient receiving prednisone and azathioprine and the second, a patient with pemphigus vulgaris who was treated with prednisone and methotrexate.

ISSN:1018-8665    

DOI:10.1159/000251106

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

28 patients with typical picture of prurigo simplex subacuta were examined for the primary eruption. In all patients, the first visible lesion was a papule, at the top of which a vesicular element was never seen. 46 biopsy specimens of the initial eruption were serially sectioned. The histological changes were found in connection with hair follicles, which consisted of spongiosis and mononuclear cell migration at the follicular epidermis and perifollicular infiltrates of mononuclear cells.

ISSN:1018-8665    

DOI:10.1159/000251107

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

This report describes a patient, whom we observed for 3 years, exhibiting a coincidence of dermatitis herpetiformis Duhring and systemic Lupus erythematosus. The difficulties involved in demarcating bullous lupus erythematosus from the more rare association of bullous pemphigoid or dermatitis herpetiformis with systemic lupus erythematosus are discussed in connection with differential, histological, direct and indirect immunofluorescence diagnostic aids.

ISSN:1018-8665    

DOI:10.1159/000251108

出版商:S. Karger AG    

年代:1976

数据来源: Karger