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1. |
How to Better Understand the Angry Back Syndrome |
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Dermatology,
Volume 184,
Issue 4,
1992,
Page 237-240
F. Pasche-Koo,
C. Hauser,
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摘要:
The angry back or excited skin syndrome consists of patch test reactions that are positive only when associated with adjacent or distant inflammatory skin lesions. Recent experiments in the mouse and man have provided the knowledge on the critical role of tumor necrosis factor in contact dermatitis as well as its importance for the induction of adhesion molecules. Based on these new findings we speculate on mechanisms that might explain this poorly understood clinical phenomenon.
ISSN:1018-8665
DOI:10.1159/000247558
出版商:S. Karger AG
年代:1992
数据来源: Karger
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2. |
Illusion and Reality in Visual Observation: A Trap for the Unwary Clinician |
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Dermatology,
Volume 184,
Issue 4,
1992,
Page 241-244
A.B. Safran,
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PDF (1743KB)
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ISSN:1018-8665
DOI:10.1159/000247559
出版商:S. Karger AG
年代:1992
数据来源: Karger
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3. |
Optical Illusions in Clinical Dermatology: The Mach Band Phenomenon and Afterimages |
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Dermatology,
Volume 184,
Issue 4,
1992,
Page 245-247
R.F. Wagner, Jr.,
D.L. Shriner,
K.D. Wagner,
D. Bloomquist,
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PDF (1072KB)
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摘要:
A survey of dermatologists was conducted to determine whether the perceptions of afterimages and Mach bands impacted on clinical dermatology practice. 26.5% (13/49) of respondents indicated that they perceived one or both of these optical illusions. No false-positive potassium hydroxide interpretations of skin scrapings for hyphae were reported due to perceived afterimages, and no skin biopsies were reportedly performed as a result of Mach bands.
ISSN:1018-8665
DOI:10.1159/000247560
出版商:S. Karger AG
年代:1992
数据来源: Karger
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4. |
Evaluation of Human Papillomavirus Type 5 on Frozen Sections of Multiple Lesions from Transplant Recipients with in situ Hybridization and Non-lsotopic Probes |
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Dermatology,
Volume 184,
Issue 4,
1992,
Page 248-253
C. Soler,
Y. Chardonnet,
S. Euvrard,
M.C. Chignol,
J. Thivolet,
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PDF (2570KB)
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摘要:
Transplant recipients are at high risk to develop multiple cutaneous lesions after grafting. The frequency of the potentially oncogenic human papillomavirus (HPV) type 5 DNA was evaluated in cutaneous lesions taken from sun-exposed areas in transplant recipients (92 lesions and 5 samples from normal skin) and compared with a nontransplanted population (22 lesions and 7 samples from normal skin) using in situ hybridization and biotinylated probes to HPV types 1 2, 5, 16 and 18. HPV type 5 DNA was identified in 8/92 cutaneous lesions of transplanted recipients: 3 warts, 1 case of seborrheic keratosis, 2 actinic keratoses and 2 keratoacanthomas. HPV type 5 DNA was not detected in 27 malignant tumors (8 basal cell carcinomas and 19 squamous cell carcinomas) from transplant recipients. HPV DNA type 5 was detected in only 1 case of squamous cell carcinoma from the general population. The presence of HPV DNA 5 was confirmed with Southern blotting in 2 out of 6 cases from transplant recipients. The reaction was negative with the squamous cell carcinoma from nontransplant recipients. These data indicate that the presence of HPV DNA type 5 is not very frequent; it can be detected with in situ hybridization and nonisotopic probe, which is easier to handle than Southern blot.
ISSN:1018-8665
DOI:10.1159/000247561
出版商:S. Karger AG
年代:1992
数据来源: Karger
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5. |
Polymorphisms of HLA Class III Genes in Allergic Contact Dermatitis |
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Dermatology,
Volume 184,
Issue 4,
1992,
Page 254-259
G. Orecchia,
L. Perfetti,
O. Finco,
E. Dondi,
M. Cuccia,
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PDF (2113KB)
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摘要:
HLA class III polymorphisms (BF, C4A, C4B) were studied in 55 patients of different age and sex suffering from allergic contact dermatitis, with sensitization to different substances. In the overall group of patients no significant correlation between the disease and HLA markers was found. BF F allele was present in 34% and BS S in 64% of patients suffering from allergic contact dermatitis to nickel only versus 16.45% (relative risk, RR = 2.61) and 80.76% (RR = 0.42), respectively, of the control population. The BF FB subtype frequency was 23.91% versus 7.57% in the control samples (RR = 3.88). We thus hypothesize that this polymorphic serum protein might be involved in the pathogenesis of allergic contact dermatitis to nickel.
ISSN:1018-8665
DOI:10.1159/000247562
出版商:S. Karger AG
年代:1992
数据来源: Karger
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6. |
Contact Allergy to Isothiazolinone Derivatives: Unusual Clinical Presentations |
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Dermatology,
Volume 184,
Issue 4,
1992,
Page 260-264
M.-A. Morren,
A. Dooms-Goossens,
J. Delabie,
Ch. De Wolf-Peeters,
K. Marien,
H. Degreef,
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PDF (2129KB)
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摘要:
Contact allergic reactions to the mixture of 5-chloro-2-methyl-4-isothiazoline-3-one and 2-methyl-4-isothiazoline-3-one are most frequently associated with intolerance to cosmetics. The present article points out that such reactions, particularly on the face, can have unusual clinical presentations that are very similar to seborrheic eczema, lupus erythematosus, lymphocytic infiltrate or photodermatitis. Atopic dermatitis is also often erroneously suspected.
ISSN:1018-8665
DOI:10.1159/000247563
出版商:S. Karger AG
年代:1992
数据来源: Karger
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7. |
Concomitance of Psoriasis and Atopic Dermatitis |
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Dermatology,
Volume 184,
Issue 4,
1992,
Page 265-270
W.E. Beer,
A.E. Smith,
J.Y. Kassab,
P.H.S. Smith,
Rowland Payne,
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PDF (2192KB)
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摘要:
There is a widespread belief that psoriasis (Ps) and atopic dermatitis (AD) are clinically mutually exclusive. A prospective study was undertaken to record the concurrent and/or consecutive coincidence of the two conditions and any shared clinical features. Patients attending a dermatology clinic were systematically examined for the presence of Ps and/or AD. Nine hundred and eighty-three patients were studied – 428 with Ps, 224 with AD, 45 with both Ps and AD, and 286 controls. Of AD patients 16.7% had Ps, and 9.5% of Ps patients had AD. In consecutive occurrences, Ps generally followed AD. The ratio of concurrent to consecutive incidences was 3:1. The two diseases are shown not to be mutually exclusive and may coexist in the same individua
ISSN:1018-8665
DOI:10.1159/000247564
出版商:S. Karger AG
年代:1992
数据来源: Karger
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8. |
Treatment of Atopic Dermatitis by Allergen-Antibody Complexes: Long-Term Clinical Results and Evolution of IgE Antibodies |
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Dermatology,
Volume 184,
Issue 4,
1992,
Page 271-274
B.P. Leroy,
J.-M. Lachapelle,
M. Jacquemin,
J.-M. Saint-Remy,
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摘要:
This study describes the long-term follow-up of the clinical response of 10 adult patients suffering from atopic dermatitis (AD) who were treated by administration of complexes made of Dermatophagoidespteronyssinus (Dpt) allergens and autologous antibodies specific to that allergen. We have already described the clinical improvement observed after 1 year of treatment involving regular injections of complexes; this improvement was maintained throughout a second year, even though the number of injections was greatly reduced. At the end of the second year of treatment, 5 patients were completely free of disease, and 3 had had a short-lasting recurrence of low-severity dermatitis. Using a disease intensity index the mean improvement for these 8 patients was 83% compared to baseline values. One patient showed a significant recurrence of symptoms, and 1 patient left the study for personal reasons when she was in good clinical condition. A significant reduction of specific anti-Dpt IgE antibody titers was observed in 7 out of the 8 patients in clinical remission, while the level of total IgE antibodies was unchanged until the very end of the study. This study not only confirms that clinical benefit can be obtained from the treatment of AD patients hypersensitive to Dpt by injections of allergen-antibody complexes but also indicates that the therapy induces a suppression of IgE antibody production that is specific for the particular allergen.
ISSN:1018-8665
DOI:10.1159/000247565
出版商:S. Karger AG
年代:1992
数据来源: Karger
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9. |
Comparative Study of Ketoconazole 2% Foaming Gel and Betamethasone Dipropionate 0.05% Lotion in the Treatment of Seborrhoeic Dermatitis in Adults |
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Dermatology,
Volume 184,
Issue 4,
1992,
Page 275-280
J.-P. Ortonne,
J.-P. Lacour,
A. Vitetta,
Y. Le Fichoux,
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PDF (2317KB)
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摘要:
Sixty-two patients with seborrhoeic dermatitis were treated topically with a 2% ketoconazole foaming gel or with a 0.05% betamethasone dipropionate lotion in a single-blind study for 4 months. Changes in the number of Pityrosporum ovale were scored by a mycologist. The investigator rated the severity of erythema, scaling and itching of the patients’ scalp, eyelashes, nasolabial folds and thorax. In addition, both the investigator and the patients evaluated the treatments globally. At the end of treatment, the response rate for ketoconazole 2% foaming gel was significantly higher than that for betamethasone dipropionate 0.05% lotion according to the global evaluation by the physician (89 vs. 62% p < 0.05) and the patient (89 vs. 65% p < 0.05). Ketoconazole was also superior to betamethasone with reference to the evolution of the symptoms, irrespective of their localization. This efficacy manifested itself by a significant reduction of the number of P. ovale on the scalp in the ketoconazole group (p < 0.001) compared to the betamethasone group, in which the count was hardly changed during therapy. The treatment was also better tolerated in the ketoconazole group (5 vs. 16 patients with side-effects, p < 0.001). It is concluded that ketoconazole 2% foaming gel offers an excellent alternative to local corticosteroids in the treatment of seborrhoeic dermatiti
ISSN:1018-8665
DOI:10.1159/000247566
出版商:S. Karger AG
年代:1992
数据来源: Karger
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10. |
Pigmented Dermatofibrosarcoma protuberans (Bednar Tumour) |
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Dermatology,
Volume 184,
Issue 4,
1992,
Page 281-282
J.I. López,
J.M. Elizalde,
A. Fdez-Larrinoa,
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PDF (884KB)
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摘要:
A case of pigmented dermatofibrosarcoma protuberans in a 37-year-old man is reported. The tumour presented as a nodular lesion located in the left scapular area. Surgical resection with wide margins was performed. No recurrences have appeared to date. The presumptive origin of this entity is briefly discussed.
ISSN:1018-8665
DOI:10.1159/000247567
出版商:S. Karger AG
年代:1992
数据来源: Karger
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