摘要:

Fibroblast cells were treated with a single dose of 8-methoxypsoralen (8-MOP) and long-wave UV irradiation in vitro and the cytotoxic effects of the treatment followed up for 5 passages. During the first passage, there was an inhibition in cell proliferation, the induction of chromosomal aberrations and the production of macrocells as well as cells with more than one nucleus. In the subsequent passages, the proliferation rate of the cells gradually normalized but there was a concomitant increase in chromosomal aberrations and in the number of macrocells and multinucleate cells. Specimens, which were taken from the uninvolved skin of psoriatic patients who had been treated between 20 and 40 times with an oral dose of 8-MOP and black light irradiation (PUVA) also revealed the presence of binucleate, tetranucleate and multinucleate epidermal cells as well as binucleate and tetranucleate dermal fibroblasts.

ISSN:1018-8665    

DOI:10.1159/000250959

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

The ultrastructural aspects of mast cells from skin lesions in 2 patients with mastocytoma were compared to those from lesions in 4 patients with mastocytosis, 3 with cutaneous and 1 with systemic involvement. In mastocytoma, the mast cells accumulated in a large mass. They revealed short cytoplasmic villi and were similar, morphologically, to mast cells of normal skin and gingiva. In the diffuse types of the disease, cutaneous and systemic, the cells were arranged in small groups. In addition to normal mast cells, there were also irregular or bizarre-shaped cells presenting long and twisted cytoplasmic protrusions. In the case with the systemic involvement and in 2 of 3 cases with apparently cutaneous diffuse lesions, the villi of adjacent cells interlaced and showed a tendency to form mast cell aggregates. The pathognomonic value of the above observation seems worthy of further investigations.

ISSN:1018-8665    

DOI:10.1159/000250960

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

The present paper reports the results of a follow-up study of 47 patients with keratoacanthomas treated solely with curettage. Only one recurrence was seen, and the cosmetic results were much better than those obtained with other types of treatment. Curettage must be considered the treatment of choice for keratoacanthomas on the face.

ISSN:1018-8665    

DOI:10.1159/000250961

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

Long-term application up to 8 weeks of a 10% urea solution provokes an epidermal thinning expressed in a decreased number of DNA-synthetizing cells. This epidermal reaction cannot be established after topical use of HTH® emulsion. Even by daily application during 8 weeks no change was seen. The absence of epidermal thinning after HTH exposure can be explained as an additive effect of urea and the other constituents of the HTH emulsion. This opinion is supported by the results after application of urea together with Tween 60 in that the acanthogenic effect of Tween 60 is decreased by addition of urea. On the other side, the therapeutic efficiency of 10% 5-fluorouracil solution can be increased remarkably by preliminary treatment with HTH emulsion. These findings could reach importance in the topical therapy with regard to the possibility to improve the effectiveness of any drug by addition of, or preliminary treatment with, urea

ISSN:1018-8665    

DOI:10.1159/000250962

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

The author presents the results of IIF examinations for pemphigus, pemphigoid antibodies and antinuclear antibodies (ANA) on the epithelium of the human palatal tonsil obtained by tonsillectomy in patients with chronic hypertrophic tonsillitis. Tonsil epithelium is more sensitive to intercellular antibodies (IC Ab), and antibodies of the basal membrane zone (BMZ Ab) than sample tissue of the monkey esophagus, while its reaction to ANA is the same or even weaker than monkey esophagus.

ISSN:1018-8665    

DOI:10.1159/000250963

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

The standard series and 35 essential oils were tested on 450 patients with dermatitis. It was found that those simultaneously sensitive to essential oils are more frequently negative than positive to balsam of Peru. The remaining 3 balsams, however (colophony, turpentine and wood tars), are also screening agents for essential oils. All four balsams reveal sensitivity to essential oils in most of the subjects tested. In patients negative to all 4 balsams of the standard series, attempts to find an essential oil with which tests would be simultaneously frequently positive with those for other essential oils failed.

ISSN:1018-8665    

DOI:10.1159/000250964

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

Generalized pruritus appeared 2 years following resection of an adenocarcinoma of the stomach. The appearance of the pruritus was the presenting symptom of recurrence of the malignant process in the stomach as well as of its metastatic spread to the liver and to the lungs.

ISSN:1018-8665    

DOI:10.1159/000250965

出版商:S. Karger AG    

年代:1977

数据来源: Karger

ISSN:1018-8665    

DOI:10.1159/000250966

出版商:S. Karger AG    

年代:1977

数据来源: Karger

ISSN:1018-8665    

DOI:10.1159/000250967

出版商:S. Karger AG    

年代:1977

数据来源: Karger