摘要:

Most of the patients with epidermodysplasia verruciformis (EV) were anergic to sensitization to dinitrochlorobenzene (DNCB) and were shown to have a decreased number of T lymphocytes and reduced lymphocyte PHA responsiveness. Preserved cell-mediated immunity (CMI) was found only in the abortive cases of EV infected with human papillomavirus type 3 (HPV-3). CMI was impaired to the same extent in patients with EV induced by HPV-3 and HPV-5, and in EV cases with combined infection with both viruses. In contrast to this, malignant transformation, i.e. of Bowen’s carcinoma type, was observed only in the 7 patients infected with HPV-5. This could indicate that malignancy in EV is related rather to the oncogenic potential of HPV-5 type than to the extent of T cell defect that was similar in both EV varieties due to HPV-3 and HPV-

ISSN:1018-8665    

DOI:10.1159/000250262

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

In 20 patients with histologically confirmed pustular bacterid the immuno-logical status was checked including lymphocyte and granulocyte components of the cellular immune system as well as HLA typing. For comparison the same investigations were carried out in 20 healthy controls. In contrast to the controls, in the group of patients the chemotactic activity of polymorphonuclear leukocytes as well as their ability to engulf either vital or heat-inactivated Candida albicans cells was found to be slightly impaired (p ≤ 0.01 and 0.05, respectively). Killing of C. albicans cells by polymorphonuclear leukocytes was strikingly impaired (p ≤ 0.001). NADPH-dependent oxidase activity, however, was found to be normal. Impairment of chemotaxis and killing activity could not be substantiated in AB pool serum, thus a serum-dependent disorder of granulocyte function has to be assumed. Lymphocyte response to phytohemagglutinin was reduced in all patients, whereas intracutaneous test reactivity to microbial antigens was normal. T and B cell counts in peripheral blood were within normal range. HLA typing revealed a significantly increased prevalence rate of HLA-B14 as compared with the control group and other patie

ISSN:1018-8665    

DOI:10.1159/000250263

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

In the epidermis from 4 cases of X-linked ichthyosis, granular cells contained a large number of keratohyalin granules of irregular surface, the largest ones having a spongy appearance. Keratinosomes were normal both in number and degree of extrusion. Corneal cells were linked by desmosomal discs up to the most superficial layers. The abnormal persistence of desmosomal discs may be a consequence of a decrease in the activity of acid hydrolases within the keratinosomes. In corneal cells there were a great number of melanosomes with normal appearance which may be responsible for scale pigmentation. Such increased number may be attributed to a deficiency in melanosome spontaneous degradation, rather than to an increased formation.

ISSN:1018-8665    

DOI:10.1159/000250264

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

In order to assess the role of mast cells in the pathogenesis of mucocuta-neous lesions of Behçet’s disease, the following investigations were performed: (1) a comparative study of ultrastructural features of mast cells in sopntaneous and reactive (pa-thergic) lesions of the process and in apparently uninvolved skin of patients in the active stage of the disease; (2) comparative estimation of the histamine content at the site of cutaneous hyperreactivity lesions and in apparently uninvolved skin of the same patients. Various forms and degrees of degranulation were revealed among the mast cells. These forms were obviously more frequent in spontaneous and reactive lesions than in the uninvolved skin, 66 and 56% as compared with 7.7%. Also the histamine content was twofold more in the reactive lesions than in the unaffected skin of the same patient, 43 ng/mg tissue as compared with 21 ng/mg tissue. The results of our study seem suggestive of an active role of mast cells in this process. The role is probably similar to that of basophils in cutaneous basophilic hypersensitivi

ISSN:1018-8665    

DOI:10.1159/000250265

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

The relative topical efficacy of indomethacin and diflumidone, a novel nonsteroidal antiinflammatory drug, for the suppression of ultraviolet-light (290–320 nm region; UVB)-induced erythema has been compared in a randomized, double-blind, placebo-controlled study in man. During the early phases of erythema development (3–6 h) following the administration of 3 minimal erythema doses (MED) of UVB, a single topical application of diflumidone and of indomethacin were found to be equal in their ability to inhibit the development of erythema compared to untreated or placebo-treated sites. At 24 h after application, the indomethacin-treated sites had significantly less erythema than did the diflumidone-treated sites. Pigmentation of test sites at 5 and 14 days following irradiation was indistinguishable at the diflumidone, placebo, or untreated sites, but relatively less pigment developed at the indomethacin-treated si

ISSN:1018-8665    

DOI:10.1159/000250266

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

4 cases of lupus vulgaris of the oral mucosa were found to be associated with asymptomatic pulmonary tuberculosis. The patients presented with single or multiple ulcerations of the mouth with an irregular periphery and a granular vegetative fundus. The diagnosis was established histologically and by the favorable and rapid response of the oral lesions to the antituberculosis therapy.

ISSN:1018-8665    

DOI:10.1159/000250267

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

Multiple primary melanomas can be observed in a frequency of 1–4% in melanoma patients, while they obviously occur more frequently in hereditary familial melanoma. In every 8th patient with an – in itself rare – hereditary familial melanoma a development of two or more primary melanomas has to be expected. Casuistically, a family is reported where a 14-year-old girl died of malignant melanoma, whose mother later on developed two primary malignant melanomas in an interval of 2

ISSN:1018-8665    

DOI:10.1159/000250268

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

The association of pilomatricomas with myotonic dystrophy is rare. The following is the 11th case. Some clinical characteristic features suggest that patients with myotonic dystrophy have a predisposition to develop pilomatricomas.

ISSN:1018-8665    

DOI:10.1159/000250269

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

Dapsone 100 mg daily led to a rapid and complete clearing of extensive vasculitic urticarial lesions in a female patient with systemic lupus erythematosus. Complement determinations revealed an intensive activation of the classical pathway before dapsone therapy. Normalization of CH50, C1 and C2 occurred during the treatment, whereas C3 and C4 remained lowered.

ISSN:1018-8665    

DOI:10.1159/000250270

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

A case is described of very low-grade angiosarcoma of a 64-year-old woman, which has histologically a typical papillary endothelial proliferation. It should be carefully diagnosed and widely excised before its extensive progression or metastasis.

ISSN:1018-8665    

DOI:10.1159/000250271

出版商:S. Karger AG    

年代:1981

数据来源: Karger