摘要:

The placenta should be an excellent source of factors which might be efficacious in the treatment of vitiligo. Proof, however, for that hypothesis is lacking. Numerous claims have been made about Melagenina. It would appear to be nontoxic if we were to assume that the medication does not contain infectious agents. The ease of application certainly is of value for patients with vitiligo who wish to try some therapy for their disease. Practically, it is very costly to travel to Cuba and to export Melagenina. The cost of shipping on airplanes plus import duties make the price very high. Unfortunately the inconvenience of the travel and the costs cannot necessarily be offset by the claims to efficacy. The biochemistry, assays for biological activity and the pharmacology studies as reported do not stand up to rigorous and acceptable scientific standards. The medication clearly needs further and intensive study. Now that the barriers between countries are being dismantled, it is hoped that the Cuban team will be able to travel to other laboratories outside of Cuba where they can continue animal studies as well as studies on melanocytes growing in culture. In addition, it is hoped that they will be able to share more about the pharmacology, the chemistry, the isolation and other chemical properties of the medication. These results can be published and will stand up to scrutiny by the world’s medical and scientific community. Until that time, patients and their physicians must recognize the uncertain quality of the claims as well as the high financial cost and potential risk of using Melagenina either within or outside of Cub

ISSN:1018-8665    

DOI:10.1159/000247848

出版商:S. Karger AG    

年代:1990

数据来源: Karger

摘要:

This report neologizes a new syndrome name, idiopathic recalcitrant facial flushing syndrome, to describe all cases of persistent facial flushing with unknown etiology. Three cases of recalcitrant flushing are described. Therapy with a variety of modalities, monitored objectively with laser Doppler velocimetry, proved unsuccessful. Some investigational and management aspects of difficult cases of idiopathic flushing are reviewed.

ISSN:1018-8665    

DOI:10.1159/000247849

出版商:S. Karger AG    

年代:1990

数据来源: Karger

摘要:

Two patients are reported in whom malignant melanoma developed at sites of low-dose superficial X-ray therapy given for treatment of benign dermatoses. No causal link has been established between melanoma and X-irradiation, but previous reports of a possible association are reviewed. The probable importance of ultraviolet exposure after X-irradiation in such patients is emphasised.

ISSN:1018-8665    

DOI:10.1159/000247850

出版商:S. Karger AG    

年代:1990

数据来源: Karger

摘要:

We studied 173 biopsies of histologically determined Bowen’s disease and looked for the presence of papillomavirus antigen using immunoperoxidase staining. Fifty-nine of the lesions were located at the head, 49 at the extremities, 36 at the trunk and 29 originated from the genital region. Papillomavirus capsid antigen could be clearly identified in 39 (22.5%) cases. Eleven (38%) of the 29 lesions located on genital skin were positive for papillomavirus capsid antigen while 28 (19.4%) of the 144 biopsies from other skin regions contained viral antigen. Our findings are suggestive of an etiologic relationship between the virus and this dermatosis which represents a special variant of squamous cell carcinoma. They indicate that human papillomaviruses may play an important role in the development of cutaneous malignancie

ISSN:1018-8665    

DOI:10.1159/000247851

出版商:S. Karger AG    

年代:1990

数据来源: Karger

摘要:

Granulocyte-macrophage colony-stimulating factor (GM-CSF), a product of activated T lymphocytes, macrophages, endothelial cells, fibroblasts, and keratinocytes, is thought to play an important role in inflammatory reactions by ‘priming’ or enhancing the functions of neutrophils and macrophages. The aim of this study was to determine whether GM-CSF is detectable in psoriatic lesions. No GM-CSF was detected by ELISA in the suction blister fluids raised on normal, psoriatic uninvolved or involved skin. In contrast, although we could not detect GM-CSF in most of the extracts from noninflammatory stratum corneum, it was readily detected in most of the scale extracts from psoriasis and sterile pustular dermatoses, and its level was significantly higher than that from the controls. These results suggest that in psoriasis GM-CSF may amplify and modulate inflammatory reactions and activated T ce

ISSN:1018-8665    

DOI:10.1159/000247852

出版商:S. Karger AG    

年代:1990

数据来源: Karger

摘要:

It is currently agreed that ambient temperature influences the sebum excretion rate. By using the Sebutape technique we have confirmed this concept, which is related to an increased delivery of sebum to the surface of the skin without an increment in the number of active sebaceous follicles.

ISSN:1018-8665    

DOI:10.1159/000247853

出版商:S. Karger AG    

年代:1990

数据来源: Karger

摘要:

A patient is described with cholinergic urticaria (CU) in whom the symptoms could be provoked by gustatory stimuli. The aim of this study was to investigate whether there is a threshold of sweating (monitored by skin water vapour loss (SVL) measurements) at which CU can be provoked. Provocations with lemon and sal-ammoniac liquorice induced transient sweating differing both in degree and duration. Only ‘doubly salted’ liquorice, which caused the most intense sweat response, resulted in urticarial lesions. This finding suggests a threshold dependency for the induction of CU. SVL measurement may be a useful method for the evaluation of sweating tests in CU patie

ISSN:1018-8665    

DOI:10.1159/000247854

出版商:S. Karger AG    

年代:1990

数据来源: Karger

摘要:

In an open study, 19 infants with a bipolar seborrhoeic rash were treated with ketoconazole 2% in cream once a day and evaluated over 10 days of treatment. At day 10, 78.9% of patients were almost cleared. Percutaneous absorption peaked 1–3 h after topical treatment, and was minimal. No plasma ketoconazole accumulation over the 10-day treatment was detected. Treatment failures corresponded to histologically psoriasiform eruptions and probable atopic dermatiti

ISSN:1018-8665    

DOI:10.1159/000247855

出版商:S. Karger AG    

年代:1990

数据来源: Karger

摘要:

In a 4-month double-blind study the effects of dimethylfumaric acid esters (DMFAE-EC) and DMFAE plus salts of monoethylfumaric acid esters (fumaric acid combination, FAC-EC) in enteric-coated tablets were compared in 22 respectively 23 patients with psoriasis. In both groups about 50% showed a considerable improvement, i.e. the initial score was more than halved. The therapeutic effects showed no significant differences in both groups with respect to the total psoriasis score or the different parameters. In the FAC-EC group the effects were obtained more rapidly. Most frequently observed side effects in both groups were flushings, stomachache and diarrhea. Due to these complaints 3 respectively 8 patients discontinued therapy. Eosinophilia, leukopenia and lymphopenia were the most frequently observed differences in lab tests. It was concluded that FAC-EC had no significantly better effect than monotherapy with DMFAE-EC. Moreover, enteric coating of the tablets did not prevent stomach complaints. Until more information has been obtained about the pharmacokinetics, the toxicity and optimal composition of the drug, the fumaric acid therapy in psoriasis should be seen as experimental.

ISSN:1018-8665    

DOI:10.1159/000247856

出版商:S. Karger AG    

年代:1990

数据来源: Karger

摘要:

EMLA cream is a topical formulation based upon the eutectic mixture of lidocaine and prilocaine and is used in clinical settings to produce local analgesia after application under occlusive dressing. A blanching reaction has been reported to occur locally after application, but it is not clear whether this reaction is caused by the anesthetic mixture, by the vehicle or the occlusion. We studied this blanching reaction in 50 healthy volunteers in a double-blind randomized assay: EMLA versus placebo, under occlusive dressing for 1 h, each subject being his own control. We found 33 cases (66%) of blanching after application of EMLA cream versus 3 cases (6%) after placebo, this difference being highly significant. Blanching was observed without delay, after removal of the dressing, and was very transient, disappearing in less than 3 h in all cases. We thus conclude that the blanching reaction is (1) frequent but very transient, and (2) determined by the anesthetic mixture included in EMLA cream and not by the vehicle alone, nor by the occlusion, since it is not found with the placebo. The precise mechanism of this reaction is unknown.

ISSN:1018-8665    

DOI:10.1159/000247857

出版商:S. Karger AG    

年代:1990

数据来源: Karger