摘要:

61 atopic dermatitis patients were subjected to a second patch testing 3–15 years (average 7.3 years) after the first contact sensitivity examination. The comparison between the results of the two studies revealed that 26.2% of patients had been sensitive to one or more haptens at the first patch testing and that 24.6% reacted positively at the second. 9 subjects (14.8%) still manifest contact sensitivity, while 6 (9.8%) reversed to positivity and 7 (11.5%) to negativity. The chemicals most frequently involved were nickel sulphate, potassium dichromate, benzoyl peroxide, diphenylguanidine. This study demonstrates that contact reactions are not linked to susceptibility to skin irritants in atopic dermatitis patients and that they tend to increase with tim

ISSN:1018-8665    

DOI:10.1159/000249377

出版商:S. Karger AG    

年代:1985

数据来源: Karger

摘要:

Two familial cases of acrokeratoelastoidosis (AKE) are reported. As a quite uncommon feature, both showed a distinct violaceous hue in addition to the characteristic clinicopathological changes. Furthermore a case of keratoelastoidosis marginalis of the hands, also showing involvement of the feet, is described. This latter syndrome may cause confusion with AKE, but appears to be a separate entity. The classification of AKE is discussed. It is suggested that AKE is a syndrome with a broad spectrum of clinical and histological abnormalities.

ISSN:1018-8665    

DOI:10.1159/000249378

出版商:S. Karger AG    

年代:1985

数据来源: Karger

摘要:

A significantly high prevalence (41%) of non-organ-specific autoantibodies, tested in immunofluorescence with sera diluted 1:40, is reported in sera from 86 alopecia patients. No correlation was found with extension and duration of the disease, topical treatment with contact agents or response to it. The relevance and significance of these findings, with particular reference to anti-smooth muscle and anti-basal cell layer antibodies, is discussed.

ISSN:1018-8665    

DOI:10.1159/000249379

出版商:S. Karger AG    

年代:1985

数据来源: Karger

摘要:

Specific binding of 125I-labeled epidermal growth factor (EGF) was measured in 62 skin tumors of different severity. Within a group of 28 benign tumors, 11 of 15 condylomata acuminata were receptor positive, whereas the investigated mesenchymal tumors and normal skin as a control were receptor negative. 6 of 18 basal cell epitheliomas bound EGF specifically. In the group of precancerous and malignant skin tumors, 7 of 8 squamous cell carcinomas had the highest number of EGF binding sites and a high affinity state, whereas 5 malignant melanomas were receptor negative. The clinical relevance of these findings is not yet clear due to the short follow-up of the patients.

ISSN:1018-8665    

DOI:10.1159/000249380

出版商:S. Karger AG    

年代:1985

数据来源: Karger

摘要:

Two further methods for the characterization of epidermal skin tumors are described: the antinuclear antibody (ANA) immunofluorescent test, which consists of indirect immunofluorescence with known high titer sera containing homogenous ANAs on epidermal skin tumors, and the ammoniacal-silver cytochemical method, which specifically stains nuclear histones. Squamous cell carcinomas (SCCs), basal cell epitheliomas (BCEs) as well as control specimens from normal skin and benign epidermal hyperplasias were studied. The ANA immunofluorescent test was positive for most SCCs, mixed SCC and basal cell carcinomas and metatypical BCEs. The ammoniacal-silver method gave a characteristic staining pattern shared among SCCs, mixed carcinomas and metatypical BCEs. BCEs, besides metatypical ones, were always negative by the ANA immunofluorescent test and the same applied for the control specimens. The ammoniacal-silver method gave a characteristic staining pattern for BCEs and control sections quite different from the staining pattern of the more aggressive forms of epidermal tumors. The two methods usually yielded parallel results.

ISSN:1018-8665    

DOI:10.1159/000249381

出版商:S. Karger AG    

年代:1985

数据来源: Karger

摘要:

Dyschromatosis symmetrica hereditaria, one of the hereditary diseases characterized by the presence of pigmented and hypopigmented spots on the extremities, was studied by the splitting dopa stain on the hypopigmented area. There were 190 ± 58/mm2 dopa-positive cells, i.e. less than the normal value of the Japanese population. This suggests that the pigment anomaly in this disease may be due to the small number of melanocytes

ISSN:1018-8665    

DOI:10.1159/000249382

出版商:S. Karger AG    

年代:1985

数据来源: Karger

摘要:

A family in Taiwan is reported to have Mai de Meleda with possibly autosomal recessive inheritance among 5 of its members. The glove- and sock-like erythrokeratosis and the hyperkeratotic plaques of the knees and elbows are the common features. Erythema of the nose, cheeks, and the perioral area in 4 affected members, actinic elastosis in 2 severely affected members, and partially impaired cell-mediated immunity in vitro in both affected and unaffected members are notable findings. Tigason (etretinate) treatment was beneficial in regard to hyperkeratinization, but not to erythema.

ISSN:1018-8665    

DOI:10.1159/000249383

出版商:S. Karger AG    

年代:1985

数据来源: Karger

摘要:

A case of familial pemphigus vulgaris is described in an uncle and his niece who developed the disease 18 years apart. The man died from pemphigus in 1964. The diagnosis was confirmed histopathologically in both cases, but immunofluorescent microscopic studies were performed only in the woman because the technique was not available in 1964. HLA typing in the woman and her daughter and sister showed A 26, BW 38 and DRW 4 in all of them. Clinical disease did not develop in the other family members.

ISSN:1018-8665    

DOI:10.1159/000249384

出版商:S. Karger AG    

年代:1985

数据来源: Karger

摘要:

Measurements of the ring size (circumference in millimeters) of the middle phalanx in 22 females suffering from generalized scleroderma (acrosclerosis) were carried out and compared to control measurements in 22 age-matched healthy females. The ring size was increased (p < 0.01) in the patients (mean 52.8 mm; range 45–61) as compared to the controls (mean 49.4 mm; range 46–52). Ring size measurements correlated well (r = 0.71; p < 0.001) with ultrasound measurement of soft tissue thickness over the middle phalanx. Ring size was larger (p < 0.001) in a group of healthy men as compared to female controls. Ring size was not correlated to age in healthy females (r = 0.06; n.s.), whereas it was in 19 healthy men studied (r = 0.78; p < 0.001). The normal range (mean ± 2 SD) for ring size in females was 45.5–53.3 mm; in males ≤ 60 years of age, the range was 48.5–59.2 mm. It is concluded that ring size is suited to quantify soft tissue changes of the digits in acrosclerosis. This method has the advantage of be

ISSN:1018-8665    

DOI:10.1159/000249385

出版商:S. Karger AG    

年代:1985

数据来源: Karger

摘要:

A 10-year-old boy with systemic lupus erythematosus exhibiting prominent features of dermatomyositis has been treated with 600 mg prednisolone intravenously per day on 3 consecutive days. Clinical and serologic improvement started after the first course of pulse therapy, and was remarkable during a second course. Basic treatment using oral prednisolone is recommended.

ISSN:1018-8665    

DOI:10.1159/000249386

出版商:S. Karger AG    

年代:1985

数据来源: Karger