摘要:

Even though the exact spectrum of tumors is not yet defined in the dysplastic nevus syndrome (DNS), the increasing frequency of associated cancers is remarkable. The observation of 4 patients with sporadic form of DNS suffering from seminoma or embryonal carcinoma of the testicle suggests that germ cell tumors of the testis represent another form of associated cancer in DNS.

ISSN:1018-8665    

DOI:10.1159/000248684

出版商:S. Karger AG    

年代:1988

数据来源: Karger

摘要:

There exists a large body of evidence that the occurrence of nevocytic nevi is closely related to skin complexion. Nevi are more frequent in Caucasians with a light skin than in those with a dark phenotype. In Orientals and Negroids nevocytic nevi are uncommon. Within a black population subjects with a relatively light complexion have greater total counts than those with a very dark skin. It is concluded that literature data dealing with mole proneness in relation to skin complexion strongly point to an association of high nevus counts with light complexion. This applies to differences between racial groups as well as to differences between complexion phenotypes within a given racial group.

ISSN:1018-8665    

DOI:10.1159/000248685

出版商:S. Karger AG    

年代:1988

数据来源: Karger

摘要:

The possible acantholytic property of captopril and thiopronine has been investigated using in vitro tissue cultures. Normal human breast skin explants have been cultured in Hanks’ balanced salt solution containing 40% normal inactivated human serum with the addition of L-cysteine, or reduced glutathione (GSH), or captopril, or thiopronine, at four different concentrations (1, 5, 10, 15 mM). Patterns of diffuse, mainly suprabasal acantholysis, with formation of bullae, were observed in the skin explants cultured with captopril or thiopronine at a 15-mM concentration after 5 days of culture; intraepidermal splits were present also at a 10-mM concentration. Focal acantholysis was seen in specimens cultured with L-cysteine or GSH at a 15-mM concentration. No lesions occurred in the samples treated with lower concentrations of the above substances, nor in controls. The results show a biochemical acantholytic potential of both captopril and thiopronine, resembling that of penicillamine in similar experimental conditions, and consonant with clinical observations of pemphigus induced by drugs containing thiol groups in their molecule (SH drugs

ISSN:1018-8665    

DOI:10.1159/000248686

出版商:S. Karger AG    

年代:1988

数据来源: Karger

摘要:

The Mosan Study Group of Pigmented Neoplasms groups 9 dermatopathologists and pathologists from 9 laboratories. We collect information concerning the epidemiology and the histological nature of malignant melanomas and of their precursors in a circumscribed part of Belgium. During the past three decades there has been a steadily increasing number of primary cutaneous malignant melanomas other than those developed on lentigo maligna. Women are twice more often affected than men. Malignant melanomas supervening on a preexisting melanocytic nevus are of rare occurrence.

ISSN:1018-8665    

DOI:10.1159/000248687

出版商:S. Karger AG    

年代:1988

数据来源: Karger

摘要:

A case of tinea faciei caused by Microsporum canis in a 14-day-old infant is reported. The incubation period was seen to be 1 week. This was a familial infection which also affected the infant’s grandmother and their pet cat and dog. Topical treatment with clotrimazole controlled the infection in the baby. A review of 14 cases (including our own) of dermatophytosis in newborn infants reported in the Japanese literature showed that newborn infants might be infected by several of these agent

ISSN:1018-8665    

DOI:10.1159/000248688

出版商:S. Karger AG    

年代:1988

数据来源: Karger

摘要:

Two cases of malignant acanthosis nigricans associated with non-Hodgkin’s lymphoma are presented. A 61-year-old negro male with a diffuse large cell non-Hodgkin’s lymphoma presented extensive acanthosis nigricans, pachydermatoglyphy and florid cutaneous papillomatosis. No viral particles were observed by electron microscopic studies of the wart-like lesions. Acanthosis nigricans disappeared under chemotherapy. The second case was a 21-year-old Caucasian male with non T non B diffuse large cell non-Hodgkin’s lymphoma. Very few cases of acanthosis nigricans associated with non-Hodgkin’s lymphoma have been reported in the literature, since to our knowledge these two are only the fourth and fifth. Pachydermatoglyphy and florid cutaneous papillomatosis are markers of malignant acanthosis ni

ISSN:1018-8665    

DOI:10.1159/000248689

出版商:S. Karger AG    

年代:1988

数据来源: Karger

摘要:

An unusual case of ‘photosensitive psoriasis’ is reported. This patient had experienced an exacerbation after sea-bathing, and psoriatic eruptions were observed on the sun-exposed areas of the body. Phototesting with ultraviolet-B (UV-B) revealed his minimal erythema dose to be within normal limits. Three to four weeks after phototesting, however, he developed a psoriatic macule on the area exposed to the suberythematous dose of UV-B. The histologic features of the skin lesion provoked by UV-B irradiation were similar to those of naturally occurring lesions on areas covered by clothes. Moreover, failure to reproduce skin lesions following tape-stripping ruled out a proneness of this patient to develop the Köbner phenomenon nonspecific

ISSN:1018-8665    

DOI:10.1159/000248690

出版商:S. Karger AG    

年代:1988

数据来源: Karger

摘要:

A 24-year-old secundigravida presented at 38 weeks of amenorrhea with typical cutaneous lesions of herpes gestationis. The newborn developed a skin rash 3 days after birth. The rash clinically resembled erythema toxicum neonatorum with dermal infiltrate of lymphocytes and eosinophilic polymorphonuclear cells forming a few intraepidermal pustules. The complement-binding antibody test for herpes gestationis factor was negative, but direct immunofluorescence study on this biopsy demonstrated a linear deposit of IgG and complement on the basement membrane zone. The possible transmission of the disease to the newborn is discussed.

ISSN:1018-8665    

DOI:10.1159/000248691

出版商:S. Karger AG    

年代:1988

数据来源: Karger

摘要:

A 23-year-old girl affected by Papillon-Lefèvre syndrome developed, during Etretinate therapy (1 mg/kg/day), two liver abscesses caused by pyogenic bacteria and a subphrenic abscess. The immunological effects of retinoids may precipitate severe infections in patients with Papillon-Lefèvre syndrome, who probably have a basic, even though not always evident, defect of PMN chemotaxi

ISSN:1018-8665    

DOI:10.1159/000248692

出版商:S. Karger AG    

年代:1988

数据来源: Karger

ISSN:1018-8665    

DOI:10.1159/000248693

出版商:S. Karger AG    

年代:1988

数据来源: Karger