摘要:

106 patients affected by various skin diseases which did not respond to standard treatments, were improved or cured by a treatment of Synacthen-depot. There exist certain possible side-effects but these would seem to be less serious than those provoked by treatment with corticosteroids.

ISSN:1018-8665    

DOI:10.1159/000251600

出版商:S. Karger AG    

年代:1974

数据来源: Karger

摘要:

The treatment of basal cell carcinomas and senile keratoses with 5-fluoruraciI, retinoic acid ointment or DNCB in alcohol is followed by local inflammation with an erosive reaction on the tumor surface. In comparison with nontreated basal cell carcinomas the infiltrations of the corium with lymphocytes and plasmacytes is increased. This phenomenon seems to be an immunological aggression against the tumor. From the immunological point of view, this observation is concerned with the finding that only the cells of the superficial basal cell carcinomas show contact with lymphocytes and plasmacytes. The local applications seem to be of therapeutic use only in the treatment of superficial basal cell lesions.

ISSN:1018-8665    

DOI:10.1159/000251601

出版商:S. Karger AG    

年代:1974

数据来源: Karger

摘要:

During the winter of 1971/72, eleven dermatologists in private practice and the dermatological departments of the Finsen Institute and Marselisborg Hospital conducted a controlled clinical trial to investigate the effect of topically applied tretinoin in patients with acne vulgaris using a 0.02-percent cream, a 0.05-percent cream, and the cream base alone. The effect of the treatment was evaluated by counting the acne lesions, the number being arranged according to a score system. As regards the effect on comedones and papules, the tretinoin cream was significantly better than the cream base alone. A concentration of 0.05% showed a quicker onset of action and a more pronounced effect than a concentration of 0.02%. The effect of the treatment was less pronounced and not statistically significant as far as pustules and cysts were concerned. The investigation confirmed previous good experience with this form of treatment. The effect upon the placebo group was considerable. This calls for caution when the effect of new acne agents is to be evaluated. Attention is drawn to the special form of cooperation used in the investigation; in this way, it was possible to include a great number of out-patients.

ISSN:1018-8665    

DOI:10.1159/000251602

出版商:S. Karger AG    

年代:1974

数据来源: Karger

摘要:

An unusual eruption was observed in a man being treated with mitotane. His palms and soles developed an erythematous, edematous, partially petechial rash, which was present primarily in areas subjected to pressure. The patient experienced pruritus, burning, and tenderness in areas of the eruption.

ISSN:1018-8665    

DOI:10.1159/000251603

出版商:S. Karger AG    

年代:1974

数据来源: Karger

摘要:

Venous thrombosis, including superior and inferiorvena caval occlusion is considered an integral manifestation of Behçet’s disease. In this series, 5 of 11 patients (45.4%) with active Behçet’s disease had clinical evidence of present or past venous thrombosis. The mean euglobulin lysis time in the 11 subjects was found to be within the normal range: however, in 3 patients, significant impairment of fibrinolytic activity was demonstrated. Inhibition of systemic fibrinolysis may be a contributory factor in the pathogenesis of the thrombotic diathesis characteristic of Behçet’s

ISSN:1018-8665    

DOI:10.1159/000251604

出版商:S. Karger AG    

年代:1974

数据来源: Karger

摘要:

A typical case of dyskeratosis congenita (DC) is presented with its classic triad of poikiloderma, ungual dystrophy, and leukoplakial changes of the mucosal surfaces. The extensive involvement of the mucous membranes of the bronchial and gastrointestinal tracts is emphasized. For the first time, to our knowledge, chromosomal changes consisting of an increase in structural and numerical abnormalities are mentioned. Finally, some comments are made concerning the association of this disease with immunologic abnormalities, dysplasia of the reticulolymphoid and hematologic systems.

ISSN:1018-8665    

DOI:10.1159/000251605

出版商:S. Karger AG    

年代:1974

数据来源: Karger

摘要:

The carcinogen, dimethylbenzanthracene (DMBA), selectively destroys guinea pig melanocytes in vitro. Cytotoxicity of DMBA appears to be unrelated to the pigmenting capacity of the cells.

ISSN:1018-8665    

DOI:10.1159/000251606

出版商:S. Karger AG    

年代:1974

数据来源: Karger

摘要:

The present paper reports on a family (2 parents and 3 children) with a minor hereditary polydysplasia: lentiginosis on the face or body, psychic disturbances (oligophrenia, psychopathy) and behavioral troubles, dysraphia (with enuresis up to the age of 8–16 years in the children), strabism and dyscrinism. The EEG was altered in 3 of 4 cases. The three caryotypes performed were normal. The mode of transmission was dominant. The authors review the observations of lentiginosis, published in the medical literature; there is almost always an association with other developmental anomalies; sometimes there are also neuropsychical disturbances. Therefore, the lentiginosis can be generally considered as the cutaneous signature of polydysplasic, often heredo-familial syndrome

ISSN:1018-8665    

DOI:10.1159/000251607

出版商:S. Karger AG    

年代:1974

数据来源: Karger

摘要:

The special techniques required for performing X-ray distance irradiation with the ‘Dermopan’ (Siemens) have been described with emphasis on perpendicular radiat

ISSN:1018-8665    

DOI:10.1159/000251608

出版商:S. Karger AG    

年代:1974

数据来源: Karger

摘要:

Fixed drug eruptions (FDE) were investigated in 14 patients. The clinical pattern of the disease was classical. The causes of FDE were different in India as compared to other countries. Sulphonamides and analgesics were the commonest causes, though some other drugs such as tetracycline were also found to be responsible for this syndrome. Provocation tests were found useful.

ISSN:1018-8665    

DOI:10.1159/000251609

出版商:S. Karger AG    

年代:1974

数据来源: Karger