摘要:

The lack of experimental test models causes problems in comparative evaluations of photodynamic effects of 8-MOP and its possible derivatives after irradiation with blacklight or other irradiation sources. In our experiments in vitro, tests with various microorganisms and the in vivo model of experimental dermatophytosis in guinea pigs by Trichophyton mentagrophytes appeared to be suitable. In vivo, 8-MOP was applicated orally and topically in two formulations.

ISSN:1018-8665    

DOI:10.1159/000251066

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

Two patients, whom we had under surveillance since 1969, were found to develop photo-onycholysis from orally administered 8-methoxypsoralen and sunlight irradiation. Morphological examination of the nail bed revealed characteristics of a microtrauma. The photosensitizing effect of the drug induced the generation of numerous binucleate, tetranucleate and multinucleate epithelial cells as well as numerous binucleate and tetranucleate fibroblasts in the dermis.

ISSN:1018-8665    

DOI:10.1159/000251067

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

In a clinical test 8-MOP Basotherm (Meladinine®) proved to be more efficient than 8-MOP Sigma prepared by our hospital pharmacy, as a photosensitizer in the PUVA treatment. This difference is significant (p = 0.002)

ISSN:1018-8665    

DOI:10.1159/000251068

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

In a double-blind controlled multicenter trial consisting of 257 patients with acne vulgaris an 8-week topical treatment with the retinoic acid derivative Ro 11-1430 (0.1% lotion) was compared with vitamin A acid (0.05% lotion) and the lotion alone (placebo). In reducing the number of comedones vitamin A acid was superior to Ro 11-1430, which was significantly better than placebo. The reduction in number of papules and pustules was not statistically significant on either treatment. Local side effects, i.e. erythema, desquamation, burning and pruritus occurred more frequently and were more severe on vitamin A acid than on Ro 11-1430 and placebo which did not differ. No correlation was found between incidence and severity of local reactions and therapeutic effect.

ISSN:1018-8665    

DOI:10.1159/000251069

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

Six skin biopsies of one patient, from foci of chronic lupus erythematosus in different stages of development of the disease and from unchanged skin were examined by electron microscope. The aim of the investigations performed was to check the presence of reticulotubular structures in these samples. Reticulotubular structures appeared in numerous quantities in early foci, while in scarred foci, as in structurally unchanged skin, they were, although always present, rare.

ISSN:1018-8665    

DOI:10.1159/000251070

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

A case with anhidrotic ectodermal dysplasia is reported. He is a male belonging to a family which could suggest a recessive X-linked pattern of inheritance. The characteristics which are found in this patient are compared with those described by other authors in the medical bibliography.

ISSN:1018-8665    

DOI:10.1159/000251071

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

Parabens are the most frequently used preservative in dermatological medications. Some allergies have been reported to parabens, but these risks must be considered with respect to the benefits of parabens in concentrations used as preservatives in dermatological formulations. Considering the alternatives to parabens in preservatives and placing perspective on the reported allergies we still find parabens to be a useful preservative with minimal risk relative to its benefits.

ISSN:1018-8665    

DOI:10.1159/000251072

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

A young woman aged 21 developed acne eruption after 3 weeks treatment with lithium carbonate.

ISSN:1018-8665    

DOI:10.1159/000251073

出版商:S. Karger AG    

年代:1977

数据来源: Karger

ISSN:1018-8665    

DOI:10.1159/000251074

出版商:S. Karger AG    

年代:1977

数据来源: Karger

ISSN:1018-8665    

DOI:10.1159/000251075

出版商:S. Karger AG    

年代:1977

数据来源: Karger