摘要:

We report an exceptional case of porokeratosis of Mibelli in a 9-year-old girl. The lesions appeared when she was 4 years of age; they are located bilaterally and symmetrically on the lips. The clinical appearance suggests atrophic annular lichen planus rather than porokeratosis of Mibelli. Histopathological examination showed a typical picture of porokeratosis of Mibelli.

ISSN:1018-8665    

DOI:10.1159/000250133

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

The authors present a survey of the side effects of beta-blocking agents. Practolol has been linked with a lupus syndrome caracterized by biological abnormalities and eventually clinical signs; later on, other beta-blocking agents have been able to induce such manifestations. Thus, all beta-blocking agents proved hazardous and they must be prescribed with extreme caution in patients with immunological imbalance. Furthermore, pruritus and lichenoid or psoriasiform dermatitis have been documented. This must be kept in mind in the presence of any unspecific rash in elderly patients.

ISSN:1018-8665    

DOI:10.1159/000250134

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

8 patients with parapsoriasis guttata were treated by oral photochemotherapy. In 6 of them, complete clearing was obtained. Many suggestions concerning the mechanism of action of oral photochemotherapy in parapsoriasis guttata are discussed.

ISSN:1018-8665    

DOI:10.1159/000250135

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

A patient suffering from an advanced and inoperable gastric carcinoma developed an unusual paraneoplastic syndrome, consisting of intensive pruritus, acanthosis nigricans, sign of Leser-Trélat (seborrhoic keratoses and freckles), warty and papillomatous excrescences, palmoplantar hyperkeratosis and florid papillomatous and granular lesions of the mouth mucosa. The whole skin of the patient was involved. The authors believe this disorder to be generalized acanthosis nigricans. As a cause they suggest the possibility of a growth-stimulating factor, produced by the tumor cells. The relationship of acanthosis nigricans with the sign of Leser-Trélat is discusse

ISSN:1018-8665    

DOI:10.1159/000250136

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

The clinical course of a patient with Sézary syndrome presenting under bullous form is described. The bullae were flaccid on a non-erythematous base. Indirect and direct immunofluorescence were both negative. In the peripheral blood WBC was high (54,000/mm3) and large cells with T lymphocyte properties and small cells with ‘null’ cell features were present. Blister fluid contained only large, E-rosette-positive and α-naphthylacetate esterase-positive Sézary cells. A remarkable spontaneous cyclicity was observed: marked reduction in the number of large circulating Sézary cells each time bullae appeared. This suggests that only the large cells were capable of migrating to the skin and from the skin to periphera

ISSN:1018-8665    

DOI:10.1159/000250137

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

The histological and ultrastructural appearance of the skin is reported in a case of homocystinuria. By optical microscopy, the collagen fibers appear granulose and non fascicular in the superficial dermis; in the deeper layers they are rare; the elastic network of the medium and lower dermis is thick and disrupted. Electron microscopically, some fibroblasts exhibit large autophagic vacuoles; the collagen fibers are normal while the elastic fibers are broken and dense; the dermal capillaries are normal. Vitamin B6 has shown its action by recoloring the patient’s hai

ISSN:1018-8665    

DOI:10.1159/000250138

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

Studies were performed in 89 patients with active psoriasis and in 10 normal volunteers. Areas of uninvolved skin of 10 × 10 cm in size were demarcated and closely observed for 14 days. In 54 patients with psoriasis, there developed very fine, erythematous papules almost at skin level (with no scaling of the surface), which changed in the course of observation into typical pinpoint papules. Histological and histochemical studies of these finest changes, referred to as prepinpoint papules, revealed fairly abundant infiltrates composed in a large part of polymorphonuclears. The cells penetrated into the epidermis forming focally small accumulations in the stratum corneum. The granular layer became atrophied or blurred, the stratum corneum was orthokeratotic and there was no epidermal proliferation, i.e. no psoriatic features. Immunofluorescence studies showed in about 50% of prepinpoint papules in vivo fixed immunoglobulins, and in 20% of them also complement. The studies point to the role of polymorphonuclears in the earliest stages of the development of psoriatic lesions

ISSN:1018-8665    

DOI:10.1159/000250139

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

Optical microscopical studies were carried out on biopsies from 22 patients affected by saburral tongue (ST). The histopathological pattern consisted of a papillomatous acanthosis covered with a very thick horny layer. Abundant colonies of banal germs were seen in the keratin. There was an alternation of suprapapillary orthokeratosis and interpapillary parakeratosis. Under the keratin layer all the keratinocytes were large and clear with a glycogen-filled cytoplasm. Two specimens, studied with a transmission electron microscope, only showed that the keratinocytes were filled with glycogen. The clear glycogen-filled epithelial cells are common either in normal lingual epithelium or in some pathological conditions. The microscopic field of ST is quite similar to that of the hairy black tongue; but these peculiar clinical aspects of the tongue do not evolve one through the other.

ISSN:1018-8665    

DOI:10.1159/000250140

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

The occurrence of a Kaposi sarcoma during the course of a therapy for a pemphigus vulgaris is reported. Only five such associations have been previously described in the literature. On the other hand, several works have reported simultaneous occurrence of a Kaposi sarcoma with anomalies of the immune or lymphoïd systems (lymphoma, Hodgkin disease, Waldenström disease, mycosis fongoïdes). Hypothesis concerning the Kaposi sarcoma genesis can be suggested on the basis of these observations and remain to be confirm

ISSN:1018-8665    

DOI:10.1159/000250141

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

10 cases of secondary dissemination of allergic contact dermatitis in the form of erythema multiforme-like or purpura and vasculitis-like lesions are reported. The responsible contact allergens were various constituents of topical applications, such as pyrrolnitrin, sulfonamide, promethazine, balsam of Peru and vioform + ethylenediamine. The clinical patterns and histopathological features of the lesions are described and the possible pathogenetic mechanisms are discussed.

ISSN:1018-8665    

DOI:10.1159/000250142

出版商:S. Karger AG    

年代:1981

数据来源: Karger