ISSN:1018-8665    

DOI:10.1159/000246269

出版商:S. Karger AG    

年代:1996

数据来源: Karger

摘要:

Angiokeratomas are vascular lesions which are defined histologically as one or more dilated blood vessel(s) lying directly subepidermal and showing an epidermal proliferative reaction. At the center of pathogenesis there is a capillary ectasia in the papillary dermis. The epidermal changes in all forms of angioker-atoma are secondary. The different entities causing vessel ectasia lead to the many clinical variants of angiokeratoma. Current classification distinguishes between widespread forms (angiokeratoma corporis diffusum), which is usually associated with an inborn error of metabolism, and localized forms, which include solitary angiokeratoma, Fordyce’s angiokeratoma, angiokeratoma circumscriptum naeviforme and angiokeratoma of Mibell

ISSN:1018-8665    

DOI:10.1159/000246270

出版商:S. Karger AG    

年代:1996

数据来源: Karger

摘要:

The skin acts as a mechanical, physicochemical and immunological control and defense system, and its lymphatic vessels play a role in the regulation of cell hydration and osmosis, as well as in immunological responses. Skin-derived signals, produced in response to various agents acting on the skin, arrive with the afferent lymph at the regional lymph nodes. These signals reflect the immunological processes in the skin and may also determine the reactions in the lymph node. By analyzing afferent lymph derived from specific skin lesions it should therefore be possible to get insight into local pathomechanisms as well as the signal transmission in skin disorders. In this report, we present methodological aspects of such skin-derived lymph studies and review the results obtained from studies of sodium-lauryl-sulfate-induced irritative contact dermatitis in humans.

ISSN:1018-8665    

DOI:10.1159/000246271

出版商:S. Karger AG    

年代:1996

数据来源: Karger

摘要:

Background and Design: The skin properties of 98 postmenopausal women with hormone replacement therapy (oestradiol gel or patches) or without hormone replacement therapy were studied using non-invasive techniques: skin thickness with skin echography, skin hydration with a dryness score and measurement of capacitance, skin surface lipids with a Sebumeter® and microtopography with image analysis of cutaneous replicas. Results: In this open study we demonstrated an increase in skin thickness and sebum in the treated group in comparison to the untreated group (7–15% according to area for skin thickness, 35% for sebum). Hydration and microtopography were not different in the two groups. Conclusions: Postmenopausal women who were receiving hormonal substitution have a greater thickness and casual level than untreated women. We therefore suggest that hormonal aging exists and that cutaneous atrophy can be prevented with hormone replacement thera

ISSN:1018-8665    

DOI:10.1159/000246272

出版商:S. Karger AG    

年代:1996

数据来源: Karger

摘要:

Background: We present a 32-year-old Japanese man with psoriatic arthritis who developed recurrent episodes of hypopyon-iridocyclitis associated with exacerbations of the arthropathy. Objective: To evaluate the mechanism of the association between psoriasis and uveitis, we analyzed the rheological characteristics of the patient’s peripheral blood neutrophils during attacks and during remissions. Methods: The rheological activity of neutrophils was determined by the micropore filtration method. It was expressed as micropore filtration time when a neutrophil-erythrocyte suspension passes through a micropore filter (pore size 5 μm). Results: The micropore filtration time in this patient was longer than that of healthy control subjects (p < 0.01) and of psoriatic patients without uveitis (p < 0.05); it was also longer during the appearance of the eye disorder with the exacerbation of psoriatic arthritis than during remissions. Conclusions: Activated neutrophils in the peripheral blood of our patient were probably responsible for the attacks of hypopyon-iridocyclitis as well as the exacerbation of psoriatic skin lesions and/or arthrit

ISSN:1018-8665    

DOI:10.1159/000246273

出版商:S. Karger AG    

年代:1996

数据来源: Karger

摘要:

Background and Objective: Occurrence rates of clinical features of nail psoriasis vary considerably in the literature. Little information is available on subjective complaints of patients affected by psoriasis of the nails. Method: Interviews with 1,728 psoriatic patients concerning their nail changes and complaints are reviewed. Results: The results indicate that pitting and deformation are the most common clinical aberrations in psoriatic nails, with a positive association between the duration of skin lesions and nail psoriasis. No relation was found between age and nail psoriasis in this group. Remarkably, 51.8% of patients suffered from pain caused by the nail changes, and a large group of patients was restricted in their daily activities, housekeeping and/or profession (58.9, 56.1, 47.9%). Treatment was disappointing: only 19.3% showed marked improvement during treatment. Conclusion: This indicates that psoriasis of the nails is a more important individual and social-economic problem than previously assumed and that development of new treatments is needed.

ISSN:1018-8665    

DOI:10.1159/000246274

出版商:S. Karger AG    

年代:1996

数据来源: Karger

摘要:

Background: Stigmatization is a central experience of patients with psoriasis with a broad psychic and social impact. Objective: The purpose of this study is to identify the dimensions of stigma experience by a Questionnaire on Experience with Skin Complaints (QES; ‘Fragebogen zum Erleben von Hautbeschwer-den’). Methods: 187 in-patients with psoriasis were examined with the QES, an adopted and extended (German) version of the Feelings of Stigmatization Questionnaire by Ginsburg and Link. A factor analysis of the questionnaire was conducted and the construct validity was evaluated. Results: Five factors were found: ‘self-esteem’, ‘retreat’, ‘rejection’, ‘composure’ and ‘concealment’. Self-esteem, retreat and rejection are mainly influenced by ‘problematic regions’ affected by psoriasis, rejection also by ‘visible parts’ and retreat also by ‘invisible regions’. The influences of age, age at onset and sex on the stigma experience are small but significant. Conclusions: The QES proved to be an economical and reliable psychometric instrument to differentiate the stig

ISSN:1018-8665    

DOI:10.1159/000246275

出版商:S. Karger AG    

年代:1996

数据来源: Karger

摘要:

Background: Previous studies have demonstrated appreciable tumor induction in mouse skin by daily irradiation with high-power long-wavelength ultraviolet A (UVA). Object: The aim of the present study was to examine the enhancing effects of UVA on changes in mouse skin mediated by the tumor promoter 12-o-tetradecanoylphorbol-13-acetate (TPA) by measurement of ornithine decarboxylase (ODC) activity and morphometric analysis. In addition, we examined the inhibitory effects of curcumin, a component of turmeric, on these changes. Method: ODC activity in the epidermis of CD-1 mice was determined by the method of Russell and Snyder. Epidermal and dermal thickness, and the number of dermal infiltrating inflammatory cells were quantified using a computer-assisted image analyzer. Results: A combination of topical TPA application and UVA irradiation produced a greater increment of ODC activity at 4 h than TPA alone (p < 0.05). Histopathologically, TPA plus UVA tended to increase the dermal infiltrating inflammatory cells in contrast to TPA alone. Pretreatment of mice with curcumin significantly abrogated the TPA-induced changes in ODC activity and the dermal infiltrating inflammatory cells as well as the TPA plus UVA-mediated enhancement of these changes. Conclusion: Our data indicate that UVA irradiation (18.72 J/cm2) significantly enhances ODC induction at an early stage (4–6 h) after topical application of TPA, and aggravates the dermatitis elicited by TPA. Pretreatment with curcumin significantly inhibits these enhancing effect

ISSN:1018-8665    

DOI:10.1159/000246276

出版商:S. Karger AG    

年代:1996

数据来源: Karger

摘要:

Background: Despite the wide practical application of homoeopathy, scientific proof of its effectiveness and mechanisms is still lacking, and sound, placebo-controlled studies are scarce. Objective: The purpose of our study was to evaluate the efficacy of homoeopathy in a prospective, double-blind randomized trial. Methods: 60 children aged 6–12 years with common warts on the back of the hands were treated either with an individually selected homoeopathic preparation (n= 30) of at least a 1:1,012 dilution or with pure placebo in the form of saccharose globuli (n = 30) under double-blind conditions. The area occupied by warts was measured by computerized planimetry before and after 8 weeks of treatment. Reduction of the warty area by at least 50% was considered a response. Results: There were a total of 16 responders: 9 of 30 patients in the homoeopathic therapy group and 7 of 30 patients in the placebo group (χ2=0.34, p = 0.56). Total cure of warts occurred in 5 patients in the treated group and in 1 patient in the placebo group (χ2 = 1.46, p = 0.22). Conclusion: There was no apparent difference between the effects of homoeopathic therapy and placebo in children with common warts under the conditions of this st

ISSN:1018-8665    

DOI:10.1159/000246277

出版商:S. Karger AG    

年代:1996

数据来源: Karger

摘要:

Background: Thalidomide is used for the symptomatic treatment of recurrent aphthous stomatitis (RAS). Some authors reported remissions, but this was not evaluated. Objective: To evaluate the number of patients who could stop or reduce thalidomide treatment. Methods: Twenty-five patients with RAS treated with thalidomide and followed during at least 1 year were retrospectively studied. Results: Six patients could stop the treatment and further presented minor aphthae, 10 needed minimal daily doses of thalidomide and 7 did not respond to 100 mg daily. One patient was not evaluated because of an early side effect and one was lost to follow-up. Conclusion: This study showed that a minority of patients responded and could stop thalidomide therapy whereas another group of patients could be maintained in remission with low doses of thalidomide which may represent a means to reduce the potentially severe side effects.

ISSN:1018-8665    

DOI:10.1159/000246279

出版商:S. Karger AG    

年代:1996

数据来源: Karger