摘要:

The scanning electron microscope makes it possible to study the horny cells surface, with a very high magnification. In psoriasis, several abnormalities have been previously noticed, among which the presence of microvilli (or granulations) on the horny cells surface. Those microvilli have a diameter of 0.4 millimicr. and are grossly round shaped. On the same cells, or on other ones, holes or pores can be found. Some authors consider these formations as characteristics of psoriasis. According to them, they represent the desmosomes and may be a sign of the immaturity of psoriasic horny cells. In fact, these cells can be found in other diseases of the horny layer, and also on a normal skin. On the contrary, their shape may be more characteristic of the psoriasis. In this disease they seem smaller, more irregular and above all more sparse, and they clearly let appear the cell surface among them.

ISSN:1018-8665    

DOI:10.1159/000251531

出版商:S. Karger AG    

年代:1974

数据来源: Karger

摘要:

The architecture and the plasticity of the dermo-epidermal interface of normal and pathological human skin have been studied by scanning electron microscopy. Biopsies were incubated in a sodium bromide solution to dissociate the epidermis from the dermis. The cleavage plane was located at the level of the lamina densa of the basal membrane as evidenced by optical and transmission electron microscopy. The surface on either side has digital projections, presenting on the epithelial side the relief of the basal cells and on the dermal side the complementary architecture. The highly folded basement membrane can be considerably stretched and its architecture can be modified by two processes. A passive type results from movement transmitted to the basement membrane in response to mechanical stress. An active type, depending upon metabolic remodelling, is illustrated by the dermal downgrowth of basal cell carcinoma.

ISSN:1018-8665    

DOI:10.1159/000251532

出版商:S. Karger AG    

年代:1974

数据来源: Karger

摘要:

The specific and total acid phosphatase activities of all fractions of a differential centrifugation of homogenized normal stratum corneum and psoriatic scales were compared. The main enzyme activities of both tissues were localized in the 105,000 g supernatants, i.e. the cytoplasmatic fractions. The kinetic properties of the cytoplasmatic acid phosphatase of both tissues were studied and the influence of several inhibitors investigated. The enzymes in both tissues could be inhibited by p-chloromercuribenzoate, F––, tartrate, Be2+, Cu2+, and Zn2+. Pb2+ only affected the psoriatic enz

ISSN:1018-8665    

DOI:10.1159/000251533

出版商:S. Karger AG    

年代:1974

数据来源: Karger

摘要:

The use of synthetic fluorogenic substrate has been applied to the measurement of lipase from guinea pig epidermis. The enzyme is not inhibited by Triton X-100 in concentrations up to 2 mg/ml, has a pH optimum in the range 6.5–8.5, a Km of 1.0 × 10––6 mol/l for 4-methyl umbelliferyl butyrate and possesses maximum activity towards esters of chain length C5–C6. The levels of activity observed seem sufficiently high to preclude bacterial flora as the major source. It is therefore concluded that skin possesses endogenous lipase

ISSN:1018-8665    

DOI:10.1159/000251534

出版商:S. Karger AG    

年代:1974

数据来源: Karger

摘要:

The effect of urea on the horny layer of human epidermis has been studied with special regard to its osmotic and keratolytic effects. It has been shown that the water-binding capacity mainly must be of osmotic nature; the same effects could be achieved with about half the concentration (w/w) of sodium chloride. Pieces of upper epidermis kept in saturated urea solutions changed mechanically already after 1 week, and later it could be seen that the original quaternary structure of keratin is lost. No such changes could be seen in saturated sodium chloride solution. The results indicated that urea-containing creams, although certainly valuable in hyperkeratotic conditions, should be used with care as long-term cosmetical products.

ISSN:1018-8665    

DOI:10.1159/000251535

出版商:S. Karger AG    

年代:1974

数据来源: Karger

摘要:

Two patients with a contact hypersensitivity to metallic gold are reported; one had a nodular skin reaction, the other had a reaction of the oral mucosa. Both patients gave strongly positive patch test reactions to gold trichloride. A review of literature is given.

ISSN:1018-8665    

DOI:10.1159/000251536

出版商:S. Karger AG    

年代:1974

数据来源: Karger

摘要:

An 8-year-old girl with severe proportional growth retardation and Cushing’s syndrome with excessive osteoporosis due to excessive application of corticosteroids is presented. The adrenal function became normal and Cushing’s syndrome disappeared gradually after cessation of the betamethasone application; growth amounted to 11 cm in 9 months, corresponding with a growth rate of 15 cm/year. It is recommended that the growth of children who are treated topically with large amounts of corticosteroids for a period longer than 3 months be checked frequen

ISSN:1018-8665    

DOI:10.1159/000251537

出版商:S. Karger AG    

年代:1974

数据来源: Karger

ISSN:1018-8665    

DOI:10.1159/000251538

出版商:S. Karger AG    

年代:1974

数据来源: Karger