摘要:

Chromosome aberrations such as gaps and breaks of one or both chromatids, acentric fragments, dicentrics, ring chromosomes and other abnormal chromosomes are observed in lymphocyte and fibroblast cultures as well as in direct bone marrow preparations from patients with systemic sclerosis. A serum factor producing chromosome breaks in mitoses from healthy donors was observed in 37 of 42 scleroderma patients. The biochemical nature of this breakage factor is still undefined. Increased breakage is also noted in a high percentage of healthy family members of scleroderma patients. It is also a common feature of related disorders such as lupus erythematosus, dermatomyositis, periarteritis nodosa and rheumatoid arthritis. An increase in chromosome breaks and rearrangements is also present in NZB mice developing spontaneously an autoimmune disorder that has been extensively studied by workers interested in lupus erythematosus. The similarity of the cytogenetic findings provides the opportunity to use these mice as an experimental model to investigate relationships between immunological perturbations and chromosomal aberrations.

ISSN:1018-8665    

DOI:10.1159/000251109

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

Complement-fixing antibodies to the heat-inactivated keratinase II of Trichophyton mentagrophytes var. granulosum were detectable in sera from approximately 40% of the Hartley strain guinea pigs previously infected with this dermatophyte. However, no precipitating antibodies to the heat-inactivated keratinase II were detectable in these sera. Guinea pigs immunized with the heat-inactivated keratinase II had both complement-fixing and precipitating antibodies to the keratinase II. Circulating antibodies in sera from both the infected and the immunized guinea pigs also reacted with the active keratinase II but did not inhibit its proteolytic activity.

ISSN:1018-8665    

DOI:10.1159/000251110

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

Corneal lesions in ichthyosis, here combined with alopecia, are rarely described in the literature. The present observation relates to two sisters, whose grandparents were siblings. The mode of inheritance is autosomal recessive, as is usual in ichthyosis congenita but is also observed in ichthyosis vulgaris. The clinical picture and the histological findings correspond to ichthyosis vulgaris.

ISSN:1018-8665    

DOI:10.1159/000251111

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

In a double-blind, randomized, group-comparative clinical trial, 31 patients with acne vulgaris received topical treatment for 6-8 weeks with a lotion containing either 0.05% retinoic acid or 0.1 % of the retinoic acid derivative Ro 11-1430. The side-effects erythema, desquamation and burning were significantly less frequent with Ro 11-1430 than with retinoic acid. The treatments appeared to be approximately equally effective in reducing the number of acne elements, but due to the limited number of patients studied, the trial was admittedly not sufficient to detect differences with regard to therapeutic efficacy.

ISSN:1018-8665    

DOI:10.1159/000251112

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

A double-blind randomized evaluation of betamethasone dipropionate cream (Diprosone) compared with Locacorten 0.02% cream flumethason pivalate in 60 patients over 3 consecutive weeks showed the betamethasone dipropionate cream to be significantly more effective in the treatment of psoriasis and other steroid-responsive dermatoses

ISSN:1018-8665    

DOI:10.1159/000251113

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

17 patients with generalized vitiligo and 5 patients with localized vitiligo were treated with oral corticosteroids. Six patients with generalized vitiligo showed over 75% repigmentation in at least one of the patches. Two patients with generalized vitiligo and 1 patient with localized vitiligo showed a partial repigmentation of 25-75%, while 5 patients with generalized vitiligo and 1 patient with localized vitiligo showed a minimal repigmentation of less than 25%. Four patients with generalized vitiligo and 3 patients with localized vitiligo failed to respond. Repigmentation became evident within 4 weeks in most cases, and in general was more markedly noted in exposed areas.

ISSN:1018-8665    

DOI:10.1159/000251114

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

Case description: a 34-year-old female with the constellation of bullous pyoderma gangrenosum, Mondor’s disease, Koebner phenomenon and pleuropneumonia. Steroid therapy was successfu

ISSN:1018-8665    

DOI:10.1159/000251115

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

A case is reported of severe transient macroglossia after biopsy from the tongue in a 13-year-old boy who has had intermittent macroglossia since the age of 1 year as a result of extensive lymphangioma circumscriptum of the tongue. The acute lesions appear to result from haemorrhage into the lymphatic spaces following rupture of blood vessels in connective tissue septa and possibly secondary infection.

ISSN:1018-8665    

DOI:10.1159/000251116

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

The first case of progressive systemic sclerosis in a Nigerian is described. In addition to the typical features of the disease, the case shows affection of the peripheral nerves, a very rare complication. The latter led to a mistaken diagnosis of leprosy. The reasons for the rarity of this disorder in the indigenous Africans and its differentiating features from leprosy are discussed.

ISSN:1018-8665    

DOI:10.1159/000251117

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

A Japanese girl aged 15 months had an eruption of 3 months’ duration on the face, trunk, and extremities except for the palms and soles. The lesions were infiltrated papules varying from 2 to 3 mm in diameter. Blood eosinophilia of 5% was demonstrated. Skin biopsy specimen revealed a necrobiotic palisading granuloma in the corium. All lesions began to subside after 1 weeks’ administration of oral corticosteroid and completely involuted in 2 months. A possible etiologic role of insect bites was conside

ISSN:1018-8665    

DOI:10.1159/000251118

出版商:S. Karger AG    

年代:1976

数据来源: Karger