摘要:

Comparative study of experimental and theoretical curves obtained by plotting transepidermal water loss against stratum corneum thickness in man, shows that every layer in the stratum corneum acts as part of the epidermal barrier to water loss. Another function of the stratum corneum is to decrease the cutaneous penetration of topical corticosteroids like difluprednate and to modify their bioavailability (‘corticosteroid reservoir’) Our data suggest that variations in stratum corneum thickness between subjects explain variation of transepidermal water loss and sensitivity difluprednate, as there is a close relationship between these two parameters. It is then conceivable that the phototype has clinical implications if there really exists a relationship between phototype, stratum corneum thickness and sensitivity to stero

ISSN:1018-8665    

DOI:10.1159/000250616

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

Using complement immunofluorescence, the capability of complement fixation by bound antibodies in pemphigus lesional skin was compared with circulating intercellular antibodies of complement-fixing type in the same patient. Five lesional skin samples from 6 patients, containing bound IgG, gave positive binding of complement (C3) supplied from fresh guinea pig serum, while only one serum sample showed complement-fixing pemphigus antibodies in the circulation. These results support the view that complement-fixing pemphigus antibodies are rapidly localized to the skin and play a role on the production of acantholysis.

ISSN:1018-8665    

DOI:10.1159/000250617

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

The percutaneous absorption of clioquinol from three different preparations for skin treatment (Vioform cream, Locacorten-Vioform cream and Vioform-Hydrocortisone cream) was evaluated. After topical dosages corresponding to 30 mg clioquinol, concentrations in the blood were below the detection limit of the analytical procedure, i.e., smaller than 0.02 μg/ml; therefore the percutaneous absorption was evaluated by measuring cumulative urinary excretion of clioquinol and was compared to that found after an equivalent oral dose. The study was carried out in 4 healthy volunteers. The topical preparations were applied under occlusive dressings. Following epicutaneous application of the three topicals in quantities containing 30 mg clioquinol each, the urinary excretion of the drug was between 1.2 and 3.6% of the applied dose. When the same dose of clioquinol was administered orally to two volunteers, 52.4 and 92.9% of the dose was excreted in the urine. Taking the urinary elimination as the minimal amount of drug absorbed, the extent of percutaneous absorption from the three dermatological preparations amounted to 1.2–3.6% of the applied dose. There was no difference in the pattern of urinary excretion products among the three topicals and the oral formulation. The bulk of clioquinol was excreted as glucuronide (mean: 96 ± 3%) and only a small fraction was excreted as sulfate (mean: 3.8 ± 3%). A small amount of free clioquinol (1.1%) was measured in 1 subject only after the oral

ISSN:1018-8665    

DOI:10.1159/000250618

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

The leucocyte migration inhibition (LIF) was investigated in 16 patients with Behçet’s disease, 5 while in the active stage of the process, 3 both during relapse and remission, and 8 during remission of symptoms. In all patients skin tests with various antigens and with a needle prick and physiological saline were simultaneously performed. The results indicate a strong correlation between the activity of the disease, skin reactivity and the reactivity of L

ISSN:1018-8665    

DOI:10.1159/000250619

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

Studies of dermal-epidermal interactions were conducted with guinea pig flank skin and intradermal injections of the irritant, Sudan IV dye in olive oil. These injections led to epidermal hyperplasia in areas overlying the irritant and the effect was most significant when the irritant was placed in the upper dermis. Basal cell mitotic activity and thymidine uptake reached a peak by 24 h and thereafter dropped rapidly. Maximal epidermal thickness (4.3 times the control) resulting from an increase in cell number occurred within 2–4 days. Despite the very short period of increased cell growth, epidermal thickness returned to control values only after a 24-day period. A similar growth response could not be induced by saline injections. A single topical application of the irritant showed a qualitatively and quantitatively different epidermal response. These experiments indicate that an intradermal irritant can lead to epidermal hyperplasia and a long-lasting epidermal thickenin

ISSN:1018-8665    

DOI:10.1159/000250620

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

Multiple cystic and proliferative follicular lesions localized on the face and the genitalia of several members of an Italian family are described. Transmission seems to be autosomal dominant, with weak penetration and variable expressivity.

ISSN:1018-8665    

DOI:10.1159/000250621

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

2 cases are reported with unusual manifestations of porokeratosis of Mibelli. In 1 case multiple atrophic facial lesions resembled plaques of chronic discoid lupus erythematosus. The second case exhibited extensive cutaneous involvement in the form of hyperkeratotic lesions in linear configuration.

ISSN:1018-8665    

DOI:10.1159/000250622

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

The occurrence of two primary malignant melanomas (superficial spreading melanoma, superficial spreading melanoma with nodular growth) in a patient with diffuse plasmacytoma treated with chemotherapy and radiation is described. Such an association does not appear to have been reported previously.

ISSN:1018-8665    

DOI:10.1159/000250623

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

A unilateral verrucous lesion with clinical characteristics of nevus unius lateralis (NUL) in an 18-year-old boy, showed histopathological features of intraepidermal basaloid cell formations simulating superficial basal cell epitheliomas. Biological significance of this phenomenon is discussed. The lesion is considered a most peculiar variant of NUL.

ISSN:1018-8665    

DOI:10.1159/000250624

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

A case is described with features both of Hailey-Hailey and Darier’s disease in a male patient who presented skin lesions since he was 8 years old. The present case is discussed in relation to data obtained from the literature, and a differential diagnosis from Grover’s disease is m

ISSN:1018-8665    

DOI:10.1159/000250625

出版商:S. Karger AG    

年代:1979

数据来源: Karger