ISSN:1018-8665    

DOI:10.1159/000250594

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

To obtain additional information on the in vivo injury induced by PUVA treatment, primary cultures were initiated from biopsies of the uninvolved skin of 15 PUVA-treated psoriatic patients, and the cells generated were analysed for morphological and chromosomal modifications. Three biopsies were obtained from each patient, the first one before commencing PUVA therapy (control) and the other two during the course of therapy. It was found that PUVA treatment has diverse effects on the mitotic activity, mitotic mechanisms and chromosomes of the cutaneous cells: (1) an inhibition of cell proliferation during the early stages of therapy followed by a reversion to normal proliferation as the PUVA treatments were continued; the production of (2) cells with more than one nucleus, (3) macrocells, (4) cells with micronuclei, (5) polyploid cells, (6) haploid cells, (7) cells with 13 chromosomes denoting a twofold reduction in the normal number of metaphase chromosomes, (8) end-associations of the chromosomes as in the pachytene phase of meiosis (9) diplotene chromosomes, and (10) chromosomal translocations.

ISSN:1018-8665    

DOI:10.1159/000250595

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

The nipples of male tan guinea pigs were used to test the effects on the skin of oral contraceptive pills and drugs. The daily topically applied doses were 1/2,000 of a pill. After 3 weeks, the nipples treated with solutions of ethinyloestradiol-containing pills had grown (200–300%), the epidermis showed acanthosis (150–250%) and strong hyperpigmentation. Mestranol-containing pills as well as pure progestogen substances did not produce these effe

ISSN:1018-8665    

DOI:10.1159/000250596

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

Chemotaxis, random migration, phagocytosis, spontaneous and stimulated NBT reduction were evaluated in neutrophüs from the peripheral blood of 8 patients with acne conglobata and were found to be normal. Only 2 patients had an increased spontaneous NBT reduction, and another exhibited a defect in neutrophil adhesiveness. On this basis, intrinsic defects of the major neutrophil functions, as evaluated in vitro, can be excluded in acne conglobata

ISSN:1018-8665    

DOI:10.1159/000250597

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

Becker’s melanosis is an uncommon condition characterized by hypertrichosis, hyperpigmentation of the epidermis, dermal melanophages and absence of nevus cells. Ultrastructural examination of such a melanotic lesion from a young white man revealed giant melanosomes. In addition, normal-sized melanosomes were found singly in the keratin ocytes of the involved skin. Dermal venules were surrounded by multiple layers of basement membran

ISSN:1018-8665    

DOI:10.1159/000250598

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

Retesting 50 patients with stasis dermatitis after a period of time (3–25 months) revealed significantly less positive patch test results (p < 0.05). All procedures were, of course, standardized. The main reasons for this were elimination of the sensitization agents in the interim and testing with a less acute skin condition. Allergens that are difficult to avoid, such as the ‘para’ compounds and balsam of Peru and related substances, show a higher degree of persistence in subsequent patch te

ISSN:1018-8665    

DOI:10.1159/000250599

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

The percutaneous absorption of chlorquinaldol from three different preparations for skin treatment (Sterosan-hydrocortisone ointment and cream, Sterosan ointment) was evaluated by measuring the cumulative urinary excretion of chlorquinaldol and was compared to that found after an equivalent oral dose. In the blood the concentrations were below the detection limit of the analytical procedure, i.e., smaller than 0.02 μg/ml. The study was carried out in 3 healthy volunteers using a four-period change-over design. The topical preparations were applied under occlusive dressings. Following epicutaneous application of the three topicals in quantities containing 30 mg chlorquinaldol each, the mean urinary excretion of the drug amounted to 11.1 ± 6.6, 19.5 ± 3.5 and 13.0 ± 2.5% of the applied dose. When the same dose of chlorquinaldol was administered orally, 67.6 ± 9.5% of the dose was excreted in the urine. Taking the urinary elimination as the minimal amount of drug absorbed, the extent of percutaneous absorption from the three dermatological preparations varied between 4.2 and 23.5% of the applied dose. There was no difference in the pattern of urinary excretion products among the three topicals and the oral formulation. The bulk of chlorquinaldol (mean: 98.0 ± 0.1%) was excreted as glucuronide, and only small fractions were excreted as sulfate (mean: 1.3 ± 0.3%) or unchanged drug (mean• 0.8

ISSN:1018-8665    

DOI:10.1159/000250600

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

46 patients with pityriasis amiantacea have been reexamined with regard to the later development of psoriasis and atopic diseases, and their occurrence in first and second degree relatives. HLA antigens of the A, B and C series were also determined. Earlier suggestions of a close association with psoriasis were not confirmed. An association with atopic diseases could not be established. Occurrence of seborrheic dermatitis seems, however, common in patients with pityriasis amiantacea.

ISSN:1018-8665    

DOI:10.1159/000250601

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

This is a report of a case with a chronic peculiar intractable pyoderma. The process started a year after splenectomy because of trauma. In the absence of an apparent other reason, we assume that a relationship exists between the operation and the skin disease.

ISSN:1018-8665    

DOI:10.1159/000250602

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

An analysis of the clinical and pathologic characteristics of 12 Nigerian patients with epidermodysplasia verruciformis (EV) is presented. Two morphological variants have been observed, typical wart-like flat-topped papules and larger confluent plaques. Seborrhoeic keratoses were observed in patients with the second morphological variety of EV. Solar elastosis was found in biopsies taken from EV lesions in this subgroup of patients. A particular rarity of seborrhoeic keratosis in Africans is emphasized as no single African case of seborrhoeic keratosis was found apart from patients with EV. No malignant epithelial skin tumours were found in the whole group. Factors underlying an apparently more benign course of EV in Africans are discussed, and the literature on EV in Africa is reviewed.

ISSN:1018-8665    

DOI:10.1159/000250603

出版商:S. Karger AG    

年代:1979

数据来源: Karger