摘要:

The time interval from starting continuous application of 2,4-dinitro-1-chlorobenzene (DNCB) epicutaneously until the appearance of an allergic contact reaction, i.e. ‘contact allergy time’ (CAT), was determined. In 34 patients initially 2.0% DNCB ointment was administered for 2 days, then 0.05% DNCB ointment was applied daily (group I). In 39 patients only the 0.05% DNCB preparation was used (group II). The median of DNCB–CAT was 11.2 ± 0.8 days in group I and 22.3 ± 3.7 days in group II (p < 0.01). In patients older than 55 years DNCB–CAT was significantly longer than in younger patients. The medians of DNCB-CAT did not differ in male and female patients. In contrast to the conventional DNCB-sensitization procedures, the CAT method allows one to measure induction and elicitation phase quant

ISSN:1018-8665    

DOI:10.1159/000249735

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

Cell-mediated immunity was studied by a leukocyte migration inhibition assay, tuberculin, and a DNCB skin test in 32 patients with recurrent herpes simplex infection and in 34 healthy individuals who served as controls. Migration inhibition was found to be significantly reduced in patients who had suffered from recurrences for more than 1 year as compared to the controls. DNCB and tuberculin sensitivity were also found to be impaired in the group with infections of long duration. The data presented suggest a functional defect in cell-mediated immunity in individuals suffering from recurrent herpes simplex which could be responsible for the relapses.

ISSN:1018-8665    

DOI:10.1159/000249736

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

The in vitro effect of peripheral blood lymphocytes on syngeneic oral epithelial cells was investigated in 23 patients suffering from lichen planus of skin and/or mucous membranes and in 18 healthy sex- and age-matched volunteers as controls. A modified 51Cr release macro-assay was used. The result shows a significant lymphocytotoxic effect on the epithelial target cells, giving evidence of cytolytic activities of blood lymphocytes on autologous epithelial cells. We consider these lymphocytes to be involved in the complex pathogenesis of lichen planus.

ISSN:1018-8665    

DOI:10.1159/000249737

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

The authors show that the use of Isotretinoin (Ro 4–3740) in cystic acne brings a reduction of chemotactic activity of the neutrophil granulocytes, like another retinoid, Etretinate, in pustular and vulgar psoriasis. This effect of retinoids, with a direct action on the polymorphonuclear leukocytes plays an important role in the recovery of the diseas

ISSN:1018-8665    

DOI:10.1159/000249738

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

In order to conform to the conditions in which a 5% benzoyl peroxide compound is being used, a new methodology has been developed and applied to 24 volunteers: photobiologic tests were performed and UVB irradiation at infra- and supra-MED times of exposure as well as UVA irradiation on usually covered and usually uncovered areas, after single and multiple applications. This double-blind study (vehicle alone and active substance alone) has been carried out in each subject. UVB phototoxicity resulted in the occurrence of an erythema for an infra-MED time of exposure and/or in changes in the erythema as compared to an adjacent control area for the supra-MED time of exposure. This was found in 8 patients (33%), only on repeatedly irradiated areas, but never with the vehicle alone. No UVA phototoxicity was evidenced. This study confirms the possible phototoxic action of benzoyl peroxide after UVB exposure. It emphasizes the usefulness of repeating the applications on both covered and uncovered areas in photosensitivity tests of a substance.

ISSN:1018-8665    

DOI:10.1159/000249739

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

We examined more than 1,400 dermatologic patients with clinically defined (but having unknown or presumably multiple etiology) affections. The investigation revealed the presence of antitoxoplasm antibodies in more than 50% of the patients, but in only 11% of the cases did the serological analyses give evidence of an active form of disease. It was possible to prove the toxoplasmic etiology of 29 cases of chronic prurigo and of 4 cases of dermohypodermitis. The same infection was involved in a few cases of different dermatoses and in two cases of dermatomyositis-like syndrome. Pseudotumoral granulomatous localizations occurred in immunosuppressed patients. We suggest an ‘immunological key’ to explain the polymorphism of the cutaneous manifestations. The practical interest of this new knowledge and its importance as a field of interdisciplinary studies are emphasi

ISSN:1018-8665    

DOI:10.1159/000249740

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

Chloracne in a factory worker manufacturing sodium pentachlorophenate, triggered by inhalation of fumes, is reported.

ISSN:1018-8665    

DOI:10.1159/000249741

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

A case of concomitant dermatophytic infection (Trichophyton schœnleinii and Microsporum rivalieri) of the scalp in a 9-year-old African girl is described

ISSN:1018-8665    

DOI:10.1159/000249742

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

A case of chronic urticaria and vitiligo, associated with thyroiditis is described. Significantly elevated thyromicrosomal antibodies were found. Autoimmune reaction is a possible cause of the patient’s thyroid disease, vitiligo and chronic urticaria. Following PUVA treatment with a total dose of 300 J/cm2 the patient’s urticaria subsided in all irradiated areas, only to relapse 2 weeks later. Subsequently courses of PUVA gave periods of remission. The treatment also induced repigmentation in the vitiliginous spots. The results indicate a local PUVA effect upon mediators or mediator-containing ce

ISSN:1018-8665    

DOI:10.1159/000249743

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

We report a 65-year-old black man whose onset of an erythroderma was followed in 6 weeks by a generalized vitiligo. The etiology of the erythroderma was unclear, although a prostate adenocarcinoma was found on evaluation. This is to our knowledge the first patient reported with a vitiligo following exfoliative dermatitis, and the first report of two uncommon markers of internal malignancy (erythroderma and vitiligo) occurring with prostate adenocarcinoma in the same patient. We present a remarkable patient who developed a generalized vitiligo after presenting with an exfoliative dermatitis. This vitiligo produced depigmentation of almost all of the patient’s skin. A workup revealed a prostate carcinom

ISSN:1018-8665    

DOI:10.1159/000249744

出版商:S. Karger AG    

年代:1983

数据来源: Karger