摘要:

Thin sections of pathologically changed skin lesions of patients suffering from purpura pigmentosa progressiva, a disorder which seems to be mediated by delayed type of allergy, were electron microscopically investigated. In 5 of the 7 cases we found cell infiltrates of the dermis consisting of many lymphocytes frequently in apposition to macrophages (histiocytes). The cell interactions observed occurred either by microvilli-like cytoplasmic protuberances or by local areas of the plasma membrane apposition. No submicroscopical alterations of the cytoplasm were found in the interacting cells although numerous macrophages show abundant microfilaments. The findings observed are interpreted as the ultrastructural substrate of cell cooperation for presenting and transfering antigens from macrophages to T lymphocytes. However, the question concerning the mechanism of the transfer remains open.

ISSN:1018-8665    

DOI:10.1159/000251059

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

Investigations were performed in 6 cases of epidermodysplasia verruciformis and 2 healthy family members. Nonspecific cell-mediated immunity (CMI) was studied by measuring response to phytohemagglutinin (PHA) and concanavalin A (Con A), percentages of E- and EAC-rosette-forming lymphocytes, bacterial skin tests, and allergic reactions to dinitrochloro-benzene (DNCB). Impairment of CMI was manifested by reduction in the percentage of E rosettes, and lowered response to PHA, and – to a lesser degree – to Con A. The immune response to DNCB sensitization was invariably negative. Impairment of CMI was greater in cases of long duration and with extensive lesions. The cases of similar duration and extent of lesions, which never showed tendency to tumor formation, were not different in CMI in comparison with cases with numerous tumors. Only in cases with very advanced tumors CMI was impaired parallel to the gravity of the patient’s general cond

ISSN:1018-8665    

DOI:10.1159/000251060

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

In a 4-week double-blind trial, Daktacort® cream was compared with each of its constituents (i.e. miconazole 2% and hydrocortisone 1%) in a total of 63 patients (aged 12–60 years) with inflamed skin infections of bacterial or mycotic origin. Daktacort treatment induced a significant improvement of all symptoms within 1 week and was superior to both miconazole and hydrocortisone in suppressing the inflammation. This tendency persisted throughout the trial but at the end miconazole treatment proved also superior to hydrocortiso

ISSN:1018-8665    

DOI:10.1159/000251061

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

Evaluation of cutaneous vasoconstriction after applications of varying duration of topical corticoids on the flexor surfaces of the forearms of 20 patients with intact skin shows a significantly faster blanching effect with diflucortolone valerate ointment than with fluocinolone acetonide and betamethasone valerate ointments. Furthermore, the test shows that even for a highly active preparation, such as the diflucortolone valerate ointment, an application time of less than 3 h only exceptionally leads to vasoconstriction in the healthy skin.

ISSN:1018-8665    

DOI:10.1159/000251062

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

Disseminated cutaneous amyloid deposits were found in four Thai patients who had unusual diffuse skin pigmentation covering the skin surface of the entire body. They also had lichenoid lesions on the pretibial areas and hypomelanotic macules on the extremities.

ISSN:1018-8665    

DOI:10.1159/000251291

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

A clear cell hidradenocarcinoma occurred in a 15-month-old child. The tumor, present from birth, recurred after two excisions and brought on metastasis to the skin, lymph nodes and lungs. Histologically, there was no evidence of malignancy, not even in the metastasis.

ISSN:1018-8665    

DOI:10.1159/000251063

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

The hitherto reported cases of hyperkeratosis lenticularis perstans are reviewed. The clinical, light- and electron-microscopical features of an additional case with a positive family history are reported. Hyperkeratosis lenticularis perstans appears to be characterized by a unique ultrastructural alteration, lack of Odland bodies in the epidermis underlying the keratotic papule.

ISSN:1018-8665    

DOI:10.1159/000251064

出版商:S. Karger AG    

年代:1976

数据来源: Karger

ISSN:1018-8665    

DOI:10.1159/000251065

出版商:S. Karger AG    

年代:1976

数据来源: Karger