摘要:

A combined histological and biomechanical study was performed in patients with localised or systemic scleroderma. The inflammatory reaction was variable in intensity and location, predominating around the superficial vascular plexus, the deep dermo-hypodermal plexus, the paraseptal plexus or in the fasciae. Secondary sclerosis resulted from the lateral fusion of bundles of collagen fibers. Three degrees of intensity of sclerosis were disclosed by our noninvasive technique of tonometry by vertical traction of the skin in vivo. That measurement allowed a follow-up of the evolution of the disease and a control of the therapeutic efficacy.

ISSN:1018-8665    

DOI:10.1159/000249513

出版商:S. Karger AG    

年代:1985

数据来源: Karger

摘要:

The skin of patients with atopic dermatitis (AD) is severely colonized with Staphylococcus aureus. Therefore, a study was conducted to assess some basic features of the S.aureus-specific immune response in patients with AD and healthy nonatopic individuals. Some particular features were found: (1) a selective hyporesponsiveness to purified S.aureus cell walls (PCW) in delayed skin reactivity; (2) half of our AD patients showed serum IgE to PCW and soluble S.aureus protoplast antigens; (3) elevated PCW-IgE did not correlate with positive immediate skin reactions to whole S.aureus and their cell walls; (4) regional lymphadenopathy but not impetiginization was associated with increased PCW-IgE and high total IgE. It is suggested that these changes in the immune response to S. aureus are related to the chronic S.aureus colonization of the skin.

ISSN:1018-8665    

DOI:10.1159/000249514

出版商:S. Karger AG    

年代:1985

数据来源: Karger

摘要:

Two skin biopsies of lymphadenosis benigna cutis have been analyzed by morphological and immunological methods using monoclonal and polyclonal antibodies on cryostat and paraffin sections. Follicular structures containing active germinal centers are composed of identical cell types as germinal centers of normal lymphatic tissue, e.g. centrocytes, centroblasts, immature plasma cells, dendritic reticulum cells and some T lymphocytes. Outside and inbetween the secondary follicles the infiltrate is composed of small T lymphocytes (OKT-3+, focal positive acid phosphatase reaction). Among T lymphocytes the OK.T-4+ to OKT-8+ ratio was 2:1. Within these areas, consisting almost exclusively of T lymphocytes, cells with electron microscopical features of indeterminate cells and interdigitating reticulum cells were recognized. Those cells are OKT-6+. It can be concluded that in lymphadenosis benigna cutis the infiltrate of the dermis is composed of B and T cell areas which show the same microarchitecture and morphology as in normal lymphatic tissue.

ISSN:1018-8665    

DOI:10.1159/000249515

出版商:S. Karger AG    

年代:1985

数据来源: Karger

摘要:

4 members of the same family with association of multiple pilomatricomas and myotonic dystrophy are described. A muscular electron microscopic study and the electro-myographic findings are reported.

ISSN:1018-8665    

DOI:10.1159/000249516

出版商:S. Karger AG    

年代:1985

数据来源: Karger

摘要:

Two middle-aged men with a cyclic eruption of transient urticarial papules of the face are described. Deposits of mucinous material were observed in cycstic spaces in their hair follicles. In direct immunofluorescence cells bearing IgE and C1q were found scattered in the dermis and were identified as mast-cells. Both patients experienced some relief of their disease in summer.

ISSN:1018-8665    

DOI:10.1159/000249517

出版商:S. Karger AG    

年代:1985

数据来源: Karger

摘要:

1532 cases with genital ulcers were investigated, of whom 610 presented with features suggestive of chancroid; classic, multiple lesions of chancroid were observed in 312, while its other variants, i.e. dwarf, giant and phagedaenic chancroid were also seen. In addition, 162 cases had a conspicuous morphology characterised by a single ulcer which was well-defined, soft, tender, non-indurated and had weakening edges. These were termed chancroidal ulcers. The latter had a longer incubation period of 8–11 days. Absence of lymphadenopathy was prominent in these cases. The male/female ratio was 27/1. Persons of low socio-economic status in the sexually vulnerable age-group were predominantly affected. The prepuce, coronal sulcus and glans penis were the common sites of affliction in males, while the labia minora was frequently involved in females. Due to the limited value of gram-stained smears for the detection of H. ducreyi and lack of good culture media, chancroid and chancroidal ulcers should be differentiated clinicall

ISSN:1018-8665    

DOI:10.1159/000249518

出版商:S. Karger AG    

年代:1985

数据来源: Karger

摘要:

Hyperkeratotic scabies and onychomycosis were associated in an immunosuppressed patient. Onychomycosis healed spontaneously after treatment of scabies. A possible interrelationship between Sarcoptes scabiei infestation of the hyponychium and dermatophytes infestation of the nail plate could be responsible for this peculiar evolution.

ISSN:1018-8665    

DOI:10.1159/000249519

出版商:S. Karger AG    

年代:1985

数据来源: Karger

摘要:

A first case of Romberg’s syndrome from Libya is reported. Romberg’s syndrome is a rare disease causing progressive facial hemiatrophy. It was first described by Parry in 1825 and then by Romberg in 1846. Since then there have been sporadic case reports and reviews in the literature [1–5]. For the first time, we report a case from

ISSN:1018-8665    

DOI:10.1159/000249520

出版商:S. Karger AG    

年代:1985

数据来源: Karger

摘要:

A 63-year-old male patient had severe exfoliative dermatitis (erythroderma) which led to the discovery of squamous cell carcinoma of the larynx. The possibility of paraneoplastic erythroderma is discussed. Although such an aetiology is rare, 5 cases with a similar paraneoplastic syndrome have been previously reported, which cannot be considered as a merely fortuitous association of exfoliative dermatitis and visceral cancer.

ISSN:1018-8665    

DOI:10.1159/000249521

出版商:S. Karger AG    

年代:1985

数据来源: Karger

ISSN:1018-8665    

DOI:10.1159/000249522

出版商:S. Karger AG    

年代:1985

数据来源: Karger