ISSN:1018-8665    

DOI:10.1159/000247509

出版商:S. Karger AG    

年代:1992

数据来源: Karger

摘要:

In Europe, especially in the Mediterranean, the incidence of Microsporum canis infection has been on a steep increase during the recent years. In some countries (Italy) and geographic areas (Slovenia), M. canis is the most often isolated dermatophyte. In Slovenia (Yugoslavia), a dramatic increase in the incidence of M. canis infection has been observed recently, both in absolute figures and as compared to the rest of isolated dermatophytes. M. canis is a cause of tinea most prevalent in children. All attempts made during the past 6 years to eliminate the natural source of infection, represented mainly by stray cats, have failed. M. canis infection is becoming a serious epidemiologic problem in Europe. For its solution, integrated efforts of medical and veterinary services, and probably more stringent rules and controls in this particular area, will be required.

ISSN:1018-8665    

DOI:10.1159/000247510

出版商:S. Karger AG    

年代:1992

数据来源: Karger

摘要:

In the period 1987–1990, 999 patients suspected of a contact allergy were patch-tested with Kathon CG 100 ppm active ingredients aq. Of these patients, 84 (8.4%) showed a positive reaction (70% females). In 62% of these cases clinical relevance was established. Most of them suffered from contact dermatitis of the face, the hands or the perianal regio

ISSN:1018-8665    

DOI:10.1159/000247511

出版商:S. Karger AG    

年代:1992

数据来源: Karger

摘要:

The rate of sensitization to isothiazolinones (Kathon® CG) detected in Switzerland rose from 3.5% (out of 2,491 patients) in 1987 to 6.3% (out of 982 patients) in 1988 and 5.6% (out of 2,295 patients) in 1989–90. This rate of sensitization appears to be related to the more and more widespread use of isothiazolinone biocide in cosmetics, domestic products and in indust

ISSN:1018-8665    

DOI:10.1159/000247512

出版商:S. Karger AG    

年代:1992

数据来源: Karger

摘要:

Several environmental factors and chemicals have been described as being able to induce systemic scleroderma and scleroderma-like diseases. The present work reports 2 male patients with progressive systemic sclerosis and pulmonary silicosis. Both patients had occupational histories of exposure to silica and one of them of handling trichloroethylene as a degreasing agent. The clinical and analytical findings could not be distinguished from those present in idiopathic systemic scleroderma with the exception of interstitial images with calcified hilar lymph nodes in the chest X-ray suggestive of pulmonary silicosis.

ISSN:1018-8665    

DOI:10.1159/000247513

出版商:S. Karger AG    

年代:1992

数据来源: Karger

摘要:

In order to obtain a wound model in which healing involved epidermis rebuilding and epidermodermal junction (EDJ) regeneration without involvement of any dermal repair, we optimized a previous model of experimental cutaneous burning with an aluminum bar by testing various conditions of burning associated with different pre- and postburn skin treatments. On the optimized model of full-thickness epidermal burns without any dermal injury, we investigated the kinetics of regneration of 4 EDJ components, from day 2 to day 23 after burning. The epidermal healing was studied by light microscopy and EDJ regeneration by indirect immunofluorescence with one bullous pemphigoid (BP) serum, antisera to fibronectin and to type IV collagen (Coll IV) and the monoclonal antibody 4C 12-8 to laminin. Histologically. neoepidermis. detected from day 2, appeared as a reepidermization tongue which progressed from the burn edges between the overlying necrotic burned epidermis and the underlying uninjured dermis. Epidermis continuity was found to be restored at day 9. Immunohistochemícally, labelling of BP antigen (BPA), Coll IV and laminin extended all along the neo-EDJ, from day 2 to day 23. In contrast, fibronectin labelling was detected only in the proximal and median portions of the neo-EDJ before day 7, then all along the neo-EDJ, from day 7 to day 23. For all the components except Coll IV, the intensity of the labelling beneath the neoepidermis was higher than that of the residual labelling remaining under the necrotic epidermis. Therefore, BPA and laminin regenerated synchronously to neoepidermis whereas fibronectin first regenerated with delay, then synchronously. For Coll IV. since the intensities of labelling beneath the neoepidermis and beneath necrotic epidermis were roughly equal, no conclusion could be drawn. Globally, regneration of EDJ components proceeded sequentially in a first phase, then synchronously with the neoepidermis progression in a second phase. The comparison of these kinetics of EDJ regeneration with those we previously obtained in the pig on a full-thickness cutaneous wound model shows that the chronological order of expression is the same for BPA and fibronectin, but differs for laminin. This indicates that during EDJ regeneration only laminin expression is clearly influenced by the existence or the absence of simultaneous dermal healing

ISSN:1018-8665    

DOI:10.1159/000247514

出版商:S. Karger AG    

年代:1992

数据来源: Karger

摘要:

Two double-blind clinical pharmacology studies were performed in atopies in order to compare the inhibitory effects of cetirizine (CTZ) 2 HCl and terfenadine (TER) on histamine and antigen-induced skin reactions. In the first study, the subjects took single intakes of CTZ 10 mg and TER 60 mg. In the second study, they took CTZ 10 mg once a day and TER 60 mg b.i.d. for 3 weeks. CTZ was more effective than TER in inhibiting histamine skin reactivity. CTZ and TER were equally effective in inhibiting antigen-induced reactions. There was no tachyphylaxis, either for CTZ or for TER.

ISSN:1018-8665    

DOI:10.1159/000247515

出版商:S. Karger AG    

年代:1992

数据来源: Karger

摘要:

Acitretin was shown to inhibit angiogenic response to the tumorigenic SKV cell line bearing HPV16 genome and to sarcoma L-1 cell line, both in vitro and in vivo systems. The lowered angiogenic response to tumor cells was independent of duration and timing of the application of acitretin to animals. Acitretin, but not etretinate, was also found to be effective in the prevention of sarcoma tumors in mice.

ISSN:1018-8665    

DOI:10.1159/000247516

出版商:S. Karger AG    

年代:1992

数据来源: Karger

摘要:

In order to evaluate the efficacy of topical khellin the vitiligo macules of one side only were painted in 41 patients with a 2% solution of khellin in acetone and propylene glycol (90 and 10% respectively) and exposed to sunlight for a period of 4 months with 3 weekly applications and with exposure times up to 90 min. The macules of the other side were treated in 36 of the 41 patients with acetone and propylene glycol only and sun-exposed with the same schedule, while in the remaining 5 patients they were neither treated with khellin or placebo nor sun-exposed. No significant difference was evidenced between the khellin and placebo-treated sides: no excellent result (repigmentation more than 75% of the affected area) was found, and good results (repigmentation more than 50%) were found in 24.9% of khellin- plus sunlight-treated macules and in 22.3% of placebo- plus sunlight-treated macules.

ISSN:1018-8665    

DOI:10.1159/000247517

出版商:S. Karger AG    

年代:1992

数据来源: Karger

摘要:

Five of 10 patients receiving long-term recombinant interferon α-2b therapy complained of considerable hair loss. The pull test and the trichogram showed a telogen count consistent with a telogen effluvium. In 2 patients the telogen count progressively improved despite continuing the treatment, whereas in 3 patients the trichogram continued to show an increased telogen count until interferon therapy was discontinued. Pohl-Pinkus hair constrictions were also present in 2 patients

ISSN:1018-8665    

DOI:10.1159/000247518

出版商:S. Karger AG    

年代:1992

数据来源: Karger