ISSN:1018-8665    

DOI:10.1159/000247438

出版商:S. Karger AG    

年代:1992

数据来源: Karger

ISSN:1018-8665    

DOI:10.1159/000247439

出版商:S. Karger AG    

年代:1992

数据来源: Karger

摘要:

Staining of argyrophilic nucleolar organizer regions (AgNORs) is a histological technique that has been assayed on a vast array of cutaneous tumors in order to help distinguish benign from malignant lesions. In a number of papers, malignant melanomas have been found to have a higher number of black nucleolar and extranucleolar dots (i.e. AgNORs) than benign nevi, including Spitz nevus. The technique may be used for prognostic purposes, as a recent paper suggests. Melanomas with more than 3.62 AgNORs/cell have a higher probability to develop metastasis than melanomas with fewer AgNORs. The problems such an apparently simple, fast and reproducible technique may pose are discussed in detail.

ISSN:1018-8665    

DOI:10.1159/000247440

出版商:S. Karger AG    

年代:1992

数据来源: Karger

摘要:

Dermatologists are confronted daily with proliferative growths which can reach considerable size, but mean no danger to the patient. Seborrheic keratoses are one example. Other growths, such as basal cell carcinoma, are locally destructive. Normally, however, we do not hesitate to reassure the patient about the benignity of the tumor once excised. The malignancy of squamous cell carcinomas and melanoma, however, is undoubted. Thus, excessive proliferation and even local invasiveness are not sufficient to define malignancy. It is the life-threatening aspect of metastasis that physicians are mostly concerned about.

ISSN:1018-8665    

DOI:10.1159/000247441

出版商:S. Karger AG    

年代:1992

数据来源: Karger

摘要:

A retrospective analysis of 153 patients suffering from progressive systemic sclerosis failed to show any correlation between either onset or worsening of the disease and L-tryptophan ingestion. Only one woman developed typical acrosclerosis without signs of the eosinophilia-myalgia syndrome during exposure to the drug.

ISSN:1018-8665    

DOI:10.1159/000247442

出版商:S. Karger AG    

年代:1992

数据来源: Karger

摘要:

Panton-Valentine leukocidin (PVL) is a Staphylococcus aureus (SA) exotoxin, which kills human granulocytes and monocytes in vitro. Among 43 SA strains from cutaneous infections, 12 were PVL producers, whereas among 49 blood culture strains, only 1 produced PVL. Most PVL-producing strains (11/22) came from 22 primitive cutaneous infections, especially furuncles and abscesses, while only 1 PVL-producing strain came from 21 secondary infections of dermatoses such as bullous or pruritic diseases. Intradermal injections of PVL in rabbits induced edema, erythema and necrosis; histopathological changes at the injection sites consisted mainly in leukocytoclasis and vascular necrosis. All changes were dose dependent, and previous immunization of rabbits partially neutralized PVL-induced effects. Production of PVL in vivo after injections of bacteria seems to be low, and the histopathological lesions induced in the rabbit skin do not appear to be specifically related to PVL activity. However, PVL is a good candidate as a new virulence factor in cutaneous SA infections.

ISSN:1018-8665    

DOI:10.1159/000247443

出版商:S. Karger AG    

年代:1992

数据来源: Karger

摘要:

A 60-year-old Japanese female developed widespread lichenoid eruptions with pigmentation, which initially appeared in preceding erythematous skin lesions due to dermatomyositis. Thioflavine T and Dylon stainings, electron microscopy and immunohistochemistry revealed that thick amyloid deposits were present in the papillary dermis particularly beneath the epidermis. Autopsy showed no evidence of systemic amyloidosis. Electron microscopy of the lesional skin disclosed the disturbance of lamina densa formation in the epidermal basement membrane zone (BMZ). There was disruption and dissociation of the lamina densa from the basal cell, and a lamina-densa-like substance was found in the amyloid deposits. Immunofluorescence and immunoelectron microscopy showed that type IV and VII collagens, LDA-1 antigen (a noncollagenous component of the BMZ) and laminin were distributed in irregular thick deposits along the BMZ and were also present within the amyloid itself. These findings indicate that morphological and immunohistochemical abnormalities of the lamina densa may be involved in amyloid production at the interface of the epidermis and dermis, at least in this case.

ISSN:1018-8665    

DOI:10.1159/000247444

出版商:S. Karger AG    

年代:1992

数据来源: Karger

摘要:

Measurements have been performed on histological sections of normal, paralesional and affected skin of patients with solar keratoses in an attempt at quantification of the degree of dysplasia. Features of dysplasia, including the epidermal thickness, the nuclear fraction and nuclear size distribution and shape, have been individually derived and incorporated into a formula designed to reflect the degree of dysplastic change within the epidermis. Application of this ‘index of dysplasia’ has been shown to differentiate lesional epidermis from that of the surrounding and normal non-sun-exposed skin. In addition, this index correlated well with independent dermatopathologists’ assessments of the degree of dysp

ISSN:1018-8665    

DOI:10.1159/000247445

出版商:S. Karger AG    

年代:1992

数据来源: Karger

摘要:

Five cases of progressive facial hemiatrophy (PFH) are reported. A nonindurated depression on normal-colored skin was observed in the cheeks of 3 subjects, and 2 patients showed indurated, pigmented atrophic lesions associated with linear scleroderma or generalized morphea. Lipoatrophy with mild subcutaneous fibrosis was observed histologically in the patients with nonindurated depressions. In contrast, the patients with indurated lesions exhibited a marked dermal fibrosis and the disappearance of appendices in the dermis. When compared with unaffected skin used as a control, collagen and glycosaminoglycan contents were not different in diseased areas. However, the dermatan sulfate/hyaluronic acid ratio was increased 1.5- to 3.2-fold in PFH patients regardless of their clinical and histological differences. These results suggest that both types of PFH may be based on a similar connective tissue disorder.

ISSN:1018-8665    

DOI:10.1159/000247446

出版商:S. Karger AG    

年代:1992

数据来源: Karger

摘要:

We report a clinical observation, a statistically significant decrease in peripheral blood eosinophils in patients treated with low-dose cyclosporine A for severe psoriasis 225/μl at baseline to 114/μl at week 12 (p = 0.04). We discuss the potential significance of this clinical findin

ISSN:1018-8665    

DOI:10.1159/000247447

出版商:S. Karger AG    

年代:1992

数据来源: Karger