摘要:

Experiments in passive transfer of nickel allergy require highly sensitive guinea pigs and a reliable and technically usable test method. A comparison was made between two sensitization methods, the guinea pig maximization test of Magnusson and Kligman (MK) and a combined injection and painting method devised by Polak and Turk (PT). Intradermal injection was chosen as test method. The reactions to the test were greater than those of normal animals and the differences were statistically significant. With testing before the start of sensitization it was found difficult to obtain highly sensitive animals (tolerance). PT painting resulted in rather higher sensitivity with Triton X-100 than with sodium lauryl sulphate. In a comparison between the MK and PT methods, no difference in effectiveness was found provided that the animals had not been pretested. Repeated PT injections and paintings caused a further increase of the sensitivity, but the toxicity of nickel is a limiting factor.

ISSN:1018-8665    

DOI:10.1159/000251278

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

Report of a 13-year-old girl suffering from poikiloderma congenitale with warty hyperkeratoses, increased susceptibility to infections and tapetoretinal degeneration. The diminished PHA lymphocyte stimulation is an indicator of an immune cellular defect which is probably the cause of the frequent infections. The significance of keratotic lesions with regard to possible cancer development in later life is discussed.

ISSN:1018-8665    

DOI:10.1159/000251279

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

The activities of 14 acid hydrolases have been measured in normal human callus and in psoriatic scales. Values for the scales were much higher than for callus. The increase is believed to be the result of two factors: an increased synthesis of these enzymes by the psoriatic lesion and a diminished degree of inactivation during the keratinization process.

ISSN:1018-8665    

DOI:10.1159/000251280

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

Skin biopsy specimens from 12 patients with plasmo-proliferative disease (myeloma and macrogobulinemia) were histopathologically and histochemically examined. In all the cases studied (by a biopsy obtained from the hand) there were alterations in the dermal microvasculature characterized by thickening of the PAS-stained basal membrane, endothelial swelling and proliferation with partial obliteration of the vascular lumen. The lesions were morphologically similar to those found in diabetic and paralymphomatous microangiopathy but in the present investigations greater endothelial proliferation has been observed. We did not find any lesions in the healthy control group. Different immunological, metabolic and hyperviscosity mechanisms are discussed. It is interesting to report that the results for blood coagulation and carbohydrate metabolism were normal; hyperviscosity was found in the serum of the patients examined, and in 3 cases cryoglobulinemia was also found. It will be interesting to carry out further investigations on the different pathogenic and biological aspects of the skin microvascular lesions in plasmo-proliferative diseases in order to increase our knowledge of the microcirculation in immunologic malignant disorders.

ISSN:1018-8665    

DOI:10.1159/000251281

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

A young man aged 17 developed, on the left thigh, in the course of 2 years an eruption corresponding macroscopically as well as microscopically to the diagnosis lichen purpuricus. A description of this patient and a review of the scarce literature on the subject is given.

ISSN:1018-8665    

DOI:10.1159/000251282

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

Three uncomplicated cases of bullous pemphigoid, confirmed by histology and immunofluorescent studies, responded to dapsone.

ISSN:1018-8665    

DOI:10.1159/000251283

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

A 54-year-old woman with systemic sclerosis developed clinical, histo-pathologic and immunopathologic findings consistent with pemphigus vulgaris after 8 months treatment with D-penicillamine. The course of the bullous disease required sustained steroid treatment.

ISSN:1018-8665    

DOI:10.1159/000251284

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

The proportion of cases with fresh syphilis in males contracted by homosexual contacts in Helsinki before and after the change of the criminal law in 1971 was studied. Since 1971, homosexuality is by law no longer a crime in Finland. In 1964, only 2% of males with fresh syphilis admitted a homosexual contact. The same figure was 8% in 1970, and increased to about 50% in 1974 and 1975. It was concluded that a change of legislation concerning homosexuality, probably by several different routes, changed the proportion of cases of detected homosexually transmitted early syphilis. This was thought to be of special importance for case finding and controlling of the spread of syphilis.

ISSN:1018-8665    

DOI:10.1159/000251285

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

Peutz-Jeghers syndrome is an uncommon genodermatosis. The clinical and radiological features of Peutz-Jeghers syndrome are described in a 12-year-old male child. The relevant literature is briefly reviewed.

ISSN:1018-8665    

DOI:10.1159/000251286

出版商:S. Karger AG    

年代:1976

数据来源: Karger

ISSN:1018-8665    

DOI:10.1159/000251287

出版商:S. Karger AG    

年代:1976

数据来源: Karger