ISSN:1018-8665    

DOI:10.1159/000248985

出版商:S. Karger AG    

年代:1987

数据来源: Karger

摘要:

In the skin organ culture model of pemphigus, fibronectin concentrations of 300 and 500 μg/ml inhibited pemphigus plasma-induced acantholysis and intraepidermal binding of the pemphigus antibodies examined by direct immunofluorescence. A direct interaction of fibronectin with pemphigus antibodies could not be demonstrated by chromatography of pemphigus plasma on immobilized fibronectin or by incubation with fibronectin and subsequent precipitation with antifibronectin. We then measured fibronectin concentrations in the plasma of 15 patients suffering from various types of pemphigus and presenting different activities of their disease. Immunoreactive fibronectin levels in untreated patients with active disease were generally in the low normal or even clearly in the subnormal range. They had the tendency to decrease when the disease subsided during therapy with high doses of glucocorticoids, sometimes in combination with azathioprine. The fibronectin concentration in the blister fluid of a patient with acute, untreated pemphigus vulgaris was similar to that in a plasma sample taken at the same time. Skin biopsies of pemphigus patients exhibited an essentially normal fibronectin pattern in direct immunofluorescence. We discuss a possible protective role of fibronectin in pemphigus e.g., by reducing the permeability for pemphigus antibodies in the dermal-epidermal junction zone

ISSN:1018-8665    

DOI:10.1159/000248986

出版商:S. Karger AG    

年代:1987

数据来源: Karger

摘要:

Skin biopsies from pemphigus vulgaris patients in the acute phase of disease and after successful GST therapy were studied in respect to their capacity to express OKT6, OKIa1 and HLA-DR antigens. In comparison to controls, the epidermis overlaying noninvolved skin contained significantly (p = 0.0001) fewer detectable la and T6 antigen-bearing Langerhans’ cells. Lower epidermal Langerhans’ cell density in comparison to controls was detected in both prednisolone-treated and untreated patients. A normalization of prior defective antigen expression was observed in patients in remittence after GST therapy. This correlated with a normal delayed type hypersensitivity reaction (Multitest Méri

ISSN:1018-8665    

DOI:10.1159/000248987

出版商:S. Karger AG    

年代:1987

数据来源: Karger

摘要:

The behavior of Langerhans cells in skin tumors was investigated by immunohistochemical techniques using OKT6. OKT6-positive cells were numerous in squamous cell carcinomas, seborrheic keratoses and keratoacanthomas. They were rare in basal cell carcinomas, Bowen’s disease, eccrine poromas, extramammary Paget’s disease and warts. In solar keratosis, the number of OKT6-positive cells was almost equal or slightly larger compared to the normal epidermis. These results indicate that the density of Langerhans cells may not correlate with the degree of malignancy but, to a certain extent, with the nature of the membrane of tumor cells occurring e.g. during keratinizat

ISSN:1018-8665    

DOI:10.1159/000248988

出版商:S. Karger AG    

年代:1987

数据来源: Karger

摘要:

A 58-year-old man developed 3 indurative erythematous lesions like necrobiosis lipoidica on the right lower leg. He had had similar cutaneous lesions 1.5 years previously. These had been surgically excised, and a histologic diagnosis of necrobiosis lipoidica was made at another hospital. He was diagnosed as having lymphomatoid granulomatosis by lung biopsy in our hospital. Nasal involvement was confirmed in later examinations and the skin lesions were also considered to be the cutaneous manifestation of lymphomatoid granulomatosis. This outlines that cutaneous manifestations may allow early diagnosis of lymphomatoid granulomatosis.

ISSN:1018-8665    

DOI:10.1159/000248989

出版商:S. Karger AG    

年代:1987

数据来源: Karger

摘要:

A case of localized eosinophilic fasciitis (EF) is reported. Profuse hypopigmentation, guttate morphea and immunological disturbances accompanied the subcutaneous changes. The case links Shulman’s syndrome with classical localized cutaneous scleroderm

ISSN:1018-8665    

DOI:10.1159/000248993

出版商:S. Karger AG    

年代:1987

数据来源: Karger

摘要:

Lesional as well as uninvolved skin were studied by light and electron microscopy in 1 case of hyperkeratosis lenticularis perstans (Flegel’s disease). The main ultrastructural finding was a morphological alteration of lamellar (Odland) bodies. A review of the literature on the ultrastructure of Flegel’s disease is made, and the significance of the ultrastructural findings is briefly discus

ISSN:1018-8665    

DOI:10.1159/000248994

出版商:S. Karger AG    

年代:1987

数据来源: Karger

ISSN:1018-8665    

DOI:10.1159/000248995

出版商:S. Karger AG    

年代:1987

数据来源: Karger

ISSN:1018-8665    

DOI:10.1159/000248996

出版商:S. Karger AG    

年代:1987

数据来源: Karger

ISSN:1018-8665    

DOI:10.1159/000248997

出版商:S. Karger AG    

年代:1987

数据来源: Karger