摘要:

13 patients with clinically and histologically verified mycosis fungoides were treated with transfer factor as additional therapy to the hitherto conventional treatment after this had failed. After approximately 3 years, complete remission was present in 3 patients, 4 patients were significantly improved and registered as being in partial remission, while the condition was registered as no change in 3 patients. 1 patient was found worse, 1 patient had died after discontinuation of therapy and 1 patient was out of the study. In this case treatment was withdrawn because of the development of contact urticaria to nitrogen mustard, her basic therapy. The number of T lymphocytes, which was low prior to treatment, increased to normal values during the therapeutic period. During the first year a decrease in serum IgE was noted. The results of the clinical evaluation seem to indicate that transfer factor may be of value as an additional therapeutic agent in mycosis fungoides. Controlled investigations are needed and are in progress.

ISSN:1018-8665    

DOI:10.1159/000250459

出版商:S. Karger AG    

年代:1980

数据来源: Karger

摘要:

The effect of oral cyproterone acetate on hair density and diameter was studied in a clinically homogeneous group of 11 women with idiopathic hirsutism. Therapy was continued for 12 cycles of treatment. Hair density and mean hair diameter on the chin and left upper leg were measured before, immediately after and 3 months after therapy. Generally, the effect of treatment consisted of a quantitative reduction of both parameters, but the effect was not permanent after termination of therapy. Concurrently, the possible influence on plasma androgen was studied. No significant differences were found between the concentrations of plasma testosterone, dehydroepiandrosterone and androstenedione before and after treatment.

ISSN:1018-8665    

DOI:10.1159/000250460

出版商:S. Karger AG    

年代:1980

数据来源: Karger

摘要:

The HLA antigens in a family with atopic dermatitis were studied. All family members with atopic dermatitis had haplotype A2, Bw35, Cw4. It has been recently demonstrated that HLA type Bw35 is found with an increased frequency in atopic dermatitis. There appears to be an inconsistent and weak correlation between atopic dermatitis and HLA-A, HLA-B and HLA-C loci.

ISSN:1018-8665    

DOI:10.1159/000250461

出版商:S. Karger AG    

年代:1980

数据来源: Karger

摘要:

A patient with Hamman-Rich syndrome and palmo-plantar disarrangement of the epidermal ridges is reported. The significance of this association is discussed.

ISSN:1018-8665    

DOI:10.1159/000250462

出版商:S. Karger AG    

年代:1980

数据来源: Karger

摘要:

There is growing evidence that pathologic changes in the vascular system are implicated in the pathogenesis of systemic scleroderma. It has been suggested that immune complex deposition may be responsible for such changes. We measured circulating immune complexes in 10 patients with severe systemic scleroderma, 1 of whom had clinical evidence of renal disease, and in 3 patients with generalized morphea. None of the patients had significantly elevated levels. Our findings suggest that although circulating immune complexes are of diagnostic and prognostic value in other collagen vascular diseases, they do not play a major role in the pathogenesis of systemic scleroderma in patients who lack clinical evidence of renal disease.

ISSN:1018-8665    

DOI:10.1159/000250463

出版商:S. Karger AG    

年代:1980

数据来源: Karger

摘要:

The rare association of lepromatous leprosy and allergic contact dermatitis due to chromium in cement was confirmed clinically and biologically in a male patient. The apparent lack of influence of lepromatous leprosy on the development and maintenance of this dermatitis dependent upon cell-mediated immune mechanisms is discussed.

ISSN:1018-8665    

DOI:10.1159/000250464

出版商:S. Karger AG    

年代:1980

数据来源: Karger

摘要:

A case of localized cutaneous sporotrichosis is reported. The lesion was granulomatous, without lymphatic metastasis. Histological examination revealed numerous spores and asteroid bodies. Sporotrichin reaction was negative, but after treatment with potassium iodide became positive. The peculiar features of this case seem to be due to some disturbances of cellular immunity.

ISSN:1018-8665    

DOI:10.1159/000250465

出版商:S. Karger AG    

年代:1980

数据来源: Karger

摘要:

A 36-year-old woman developed vitiligo in areas with active dermatitis herpetiformis. Both diseases have been associated with autoimmune disorders. However, in the present case the vitiligo is believed to be an isomorphic reaction to the dermatitis herpetiformis lesions.

ISSN:1018-8665    

DOI:10.1159/000250466

出版商:S. Karger AG    

年代:1980

数据来源: Karger

摘要:

For the purpose of describing a new case of the Woringer-Kolopp disease, we are up-dating the problem and its classification and contributing clinical, histopathological, and ultrastructural facts which show that this is a lymphoma of the T cells and therefore should be classified along with the mycosis fungoides and the Sézary syndrome. The identification test of the lymphocytes and the ultrastructural study bring to light new facts of this disease

ISSN:1018-8665    

DOI:10.1159/000250467

出版商:S. Karger AG    

年代:1980

数据来源: Karger

摘要:

7 patients with Scopulariopsis brevicaulis onychomycosis of the toe-nails were treated locally with 1% natamycin in 60% dimethylsulphoxide. After 3–5 months treatment the fungus could no longer be isolated from the nails, and at follow-up 15 months after the completion of the treatment, 2 patients reported permanent improvement of the nails and 3 a complete cure. In 1 patient the treatment was ineffectiv

ISSN:1018-8665    

DOI:10.1159/000250468

出版商:S. Karger AG    

年代:1980

数据来源: Karger