ISSN:1018-8665    

DOI:10.1159/000247074

出版商:S. Karger AG    

年代:1994

数据来源: Karger

摘要:

Persistent and disabling fatigue associated with low-grade fever and other constitutional symptoms, without any known disorder that accounts for it, is recognized as chronic fatigue syndrome (CFS). Skin lesions occur in 10–35% of patients, but their description is inaccurate. Recurrent aphthous stomatitis or persistent Epstein-Barr virus (EBV)-related erythema multiforme have also been reported. Patients may be diagnosed as having CFS only when they fulfill at least 2 major and 8 minor criteria. Major criteria are the presence of debilitating fatigue persisting or recurring for at least 6 months and the absence of any other medical disorder that may explain it. Although different viral or nonviral etiologies have been documented, evidence implicating EBV is gaining suppor

ISSN:1018-8665    

DOI:10.1159/000247075

出版商:S. Karger AG    

年代:1994

数据来源: Karger

摘要:

The migration of human keratinocytes is dramatically influenced by the type of extracellular matrix in contact with the cells: collagen induces the cells to produce long, linear migration tracks. In this study, a migration assay and computer-assisted morphometry were used to quantitate the extent of migration and the linearity of the migration tracks for a variety of cell types. Only human keratinocytes and HT-1080 fibrosarcoma cells produced both high levels of migration (migration index > 30) and highly linear tracks (track linearity > 4.5). Human keratinocytes and HT-1080 cells share at least two other features: both synthesize copious amounts of extracellular matrix components, and both synthesize high levels of collagenase that degrades basement membrane (type IV) collagen. However, zymogram studies of collagenase production do not yield any characteristic collagenase profile which might distinguish these two types of cells from other normal and metastatic cells.

ISSN:1018-8665    

DOI:10.1159/000247076

出版商:S. Karger AG    

年代:1994

数据来源: Karger

摘要:

The metabolism of betamethasone 17-valerate was estimated using an artificial living skin equivalent (LSE). Betamethasone 17-valerate, betamethasone 21-valerate and betamethasone were measured by a normal-phase high-performance liquid chromatographic (HPLC) method. Betamethasone 17-valerate was added to the culture medium with or without LSE homogenate. Degradation profiles (%) of betamethasone 17-valerate remaining in the culture medium with skin homogenate did not differ from those without homogenate. However, the conversion of betamethasone 21-valerate to betamethasone was accelerated by skin homogenate, indicating that LSE has a sufficient level of esterase.

ISSN:1018-8665    

DOI:10.1159/000247077

出版商:S. Karger AG    

年代:1994

数据来源: Karger

摘要:

Carbamazepine is a widely used drug associated with numerous side effects including skin eruptions that appear in about 4% of patients. Epicutaneous tests have been used with variable success in skin drug reactions. The purpose of this study was to work out the efficacy of this type of test in carbamazepine reactions. Five patients with carbamazepine cutaneous reaction were studied. Clinical, laboratory and histopathological data were recorded. The 5 patients and 20 controls were tested with carbamazepine 1% in petrolatum. In 4 patients the carbamazepine epicutaneous test was positive. The 20 healthy controls were negative. Epicutaneous testing is a simple and helpful method in detecting carbamazepine hypersensitivity.

ISSN:1018-8665    

DOI:10.1159/000247078

出版商:S. Karger AG    

年代:1994

数据来源: Karger

摘要:

In old age, the epidermis tends to become dry and flaky, especially on the lower legs. However, this does not occur on the face, although long-term ultraviolet light irradiation has important effects on the differentiation of facial keratinocytes. Therefore, the differentiation of the epidermal cells of the facial skin in the young and the aged was immunohistochemically examined using antibodies against four differentiation products: filaggrin, involucrin, cystatin A (CTA) and carbonic anhydrase-like protein. The results showed that there was no difference in the amounts of the above three proteins in facial skin between the young and the aged with the exception of CTA. The amount of CTA was much greater in the facial skin of the aged. However, there was a striking decrease of filaggrin content in the skin of the lower leg in the aged. One of the reasons why no scaly skin is found on the face in the aged may be the fact that especially filaggrin does not decrease with aging.

ISSN:1018-8665    

DOI:10.1159/000247079

出版商:S. Karger AG    

年代:1994

数据来源: Karger

摘要:

X-linked adrenoleucodystrophy (ALD) is a rare disorder of the very-long-chain fatty acid (VLCFA) metabolism. Cutaneous findings observed in a 29-year-old man included patchy non-cicatricial alopecia of the scalp, intense oily seborrhoea of the head, mild dry-scaling ichthyosis-like appearance of the trunk and legs and pseudo-acanthosis nigricans of the folds. Scanning electron-microscopic examination of the scalp hair showed trichorrhexis-nodosa-like fractures and several structural anomalies of the hair shaft. The skin surface lipid profile showed a marked increase in lignoceric acid (C24:0) which comprised over 60% of the fatty acid detectable in the fractions of triglycerides, diglycerides and free fatty acids. This behaviour of the VLCFA in the surface lipids corresponds to that observed in the plasma. If this finding were confirmed, the investigation of surface lipid composition could represent a useful non-invasive technique for the study of ALD.

ISSN:1018-8665    

DOI:10.1159/000247080

出版商:S. Karger AG    

年代:1994

数据来源: Karger

摘要:

Several entities, quite often similar, share keratotic papules, usually crateriform, along the border of the hands and feet as a common clinical finding. These conditions are acrokeratoelastoidosis of Costa, focal acral hyperkeratosis, acrokeratoelastoidosis of Matthews and Harman, mosaic acral keratosis, hereditary papulotranslucent acrokeratoderma, acrokeratoderma hereditarium punctatum, degenerative collagenous plaques of the hands, keratoelastoidosis marginalis and digital papular calcinosis. We describe two further cases of focal acral hyperkeratosis in two Caucasian women, review the clinical and histological features of the related conditions and suggest that some are variants of the same entity. We propose the simplified concept of marginal papular acrokeratodermas that may be divided into (1) the hereditary type (subdivided into that with and without elastorrhexis) and (2) the acquired type.

ISSN:1018-8665    

DOI:10.1159/000247081

出版商:S. Karger AG    

年代:1994

数据来源: Karger

摘要:

The analgesic effect of topical application of EMLA cream for the curettage verrucae vulgaris was compared to local infiltration with lignocaine in 89 patients. The main purpose of this randomized study was to evaluate the patients’ overall impression of the treatment. All patients anaesthetized by lignocaine infiltration reported it as ‘an acceptable procedure’ compared to only 71% of the patients treated with EMLA. It cannot be recommended to use EMLA cream as local anaesthetic for curettage of verrucae vulgaris, presumably because the highly keratotic nature of the common warts does not allow sufficient penetration of epicutaneously applied

ISSN:1018-8665    

DOI:10.1159/000247082

出版商:S. Karger AG    

年代:1994

数据来源: Karger

摘要:

Squamous cell carcinoma complicating lichen planus is described in 3 patients. In 2, the cancers developed on the lower leg in chronic and hypertrophic lichen planus. In the other case, the cancer complicated lichen planus of the lip mucosa in a smoker. In the two cutaneous cases, the tumour and the adjacent skin showed features of lichen planus, including hypergranulosis, cytoid bodies and a lichenoid infiltrate. The association, though rare with cutaneous lichen planus when it tends to affect chronic hypertrophic lesions on the lower legs, is now well recognized with oral lichen planus. Patients with oral involvement warrant long-term follow-up, especially if they have other risk factors such as smoking or excessive ultraviolet exposure. Chronicity of lichen planus at other skin sites may also be a risk factor.

ISSN:1018-8665    

DOI:10.1159/000247083

出版商:S. Karger AG    

年代:1994

数据来源: Karger