ISSN:1018-8665    

DOI:10.1159/000248662

出版商:S. Karger AG    

年代:1988

数据来源: Karger

摘要:

Fifty patients with bullous pemphigoid were investigated over periods of up to 7 years. Sequential studies of circulating basement membrane zone (BMZ) antibody titres revealed two groups of patients: 44% had a high initial titre (> 1:160) and 56% had a low initial titre ( 1:160 continued to have high titres, whereas in those with lower titres the BMZ antibodies usually became undetectable after 4 months. The BMZ antibody titres were of no prognostic value. High titres remained high even in patients who were in remission and off treatment, and in these subjects, there was no evidence of a change in the IgG subclass. The initial BMZ IgG antibody titres showed a highly significant correlation with total serum IgE concentrations. A significant correlation also existed between total serum IgE and IgG4 concentrations, although not between the serum IgE and the peripheral blood eosinophil count. No anti-BMZ antibody of IgE class was found, nor specific IgE against inhalants and foods identified, and the significance of the high total serum IgE remains unexplained. The majority of those followed for more than 2 years were able to stop their steroid therapy without further blistering: this confirms that pemphigoid tends to be a self-limiting disease. Nine patients had a recent history of malignant disease, and this is no more than would be expected for this age group of patients: however, 3 patients presented with pemphigoid and figurate erythema and all died of neoplastic disease, suggesting that such patients should be investigated thoroughly for neoplasia.

ISSN:1018-8665    

DOI:10.1159/000248663

出版商:S. Karger AG    

年代:1988

数据来源: Karger

摘要:

Nailfold capillary abnormalities in 40 patients suffering from progressive systemic sclerosis (scleroderma; PSS) were studied by widefield nailfold capillary microscopy. Capillary enlargement and loss were graded using the rating scales of Maricq and Minkin. Capillary changes were correlated with organ involvement and immunological abnormalities. A high correlation was found between the grade of nailfold capillary changes and the clinical severity of PSS. Nailfold capillary microscopy seems to be a useful method to get quick information in order to predict organ involvement in PSS.

ISSN:1018-8665    

DOI:10.1159/000248664

出版商:S. Karger AG    

年代:1988

数据来源: Karger

摘要:

212 epitheliomata developed in two unrelated women with self-healing epitheliomata of Ferguson-Smith. Most of the lesions appear on the face, often in crops; they enlarge over 4 weeks and, without treatment, resolve over 4 months to leave a ragged scar. One of the patients developed an unusual syringoma, a papillary carcinoma of the thyroid and a mucosal squamous cell carcinoma which failed to involute spontaneously. Cytogenetic studies did not reveal any abnormality of DNA repair. Surgical excision of the epitheliomata is successful but time consuming. X-irradiation should not be used, but cryotherapy of early lesions is helpful. One patient, treated with etretinate for 24 months, has developed only 8 epitheliomata over this time, compared with 23 in the previous 24 months. Etretinate therefore appears to prevent new lesions from developing.

ISSN:1018-8665    

DOI:10.1159/000248665

出版商:S. Karger AG    

年代:1988

数据来源: Karger

摘要:

Teicoplanin is a new glycopeptide antibiotic chemically related to vancomycin with a similar bactericidal activity against aerobic and anaerobic Gram-positive bacteria but with a longer plasma elimination half-life of 40–100 h allowing a once daily parenteral administration. In an open prospective study, we treated 20 patients with skin and soft tissue infections such as erysipelas, ceilulitis, folliculitis and furunculosis with a a success rate of 84%. The peak and trough serum levels of teicoplanin were above the minimal inhibitory concentrations of the bacteria isolated and the therapeutic index measured at the plateau level was between 24 and 146. We observed a moderate increase of the transaminases in 3 patients which returned to normal at the end of treatment. We conclude that this new antibiotic, teicoplanin, is safe and effective in the treatment of skin and soft tissue infections. It can be administered once daily and is well tolerated even in long-term therap

ISSN:1018-8665    

DOI:10.1159/000248666

出版商:S. Karger AG    

年代:1988

数据来源: Karger

摘要:

A 35-year-old Black male with a long history of intravenous drug abuse developed clinical manifestations of Reiter’s syndrome, with significant joint and psoriasiform skin involvement. In addition, he had signs and symptoms compatible with human immunodeficiency virus (HIV) infection and had a positive HIV antibody test confirmed with Western blot testing. Although many dermatologic manifestations of HIV infection have been described, this is the first time that an association with Reiter’s syndrome has been reported. Recently, the development of psoriasis in other patients with HIV infection has been described. Taken together, these occurrences suggest that the purported retroviral relationship with psoriasis and related dermatoses may warrant further examinat

ISSN:1018-8665    

DOI:10.1159/000248667

出版商:S. Karger AG    

年代:1988

数据来源: Karger

摘要:

The early occurrence of seborrheic keratoses is described in 3 members of a family. The autosomal dominant transmission of seborrheic keratoses in this family provides further evidence for a genetic (polygenic) predisposition to seborrheic keratoses.

ISSN:1018-8665    

DOI:10.1159/000248668

出版商:S. Karger AG    

年代:1988

数据来源: Karger

摘要:

This paper presents light and electron microscopic findings in a case of fibrous hamartoma of infancy. Histological examination revealed different tissue components: irregular trabecular collagen fibers among mature adipose tissue, and mesenchymal cells at the border of fibrocollagenous trabeculae as well as around blood vessels. Ultrastructurally most of the tumor cells represented myofibroblasts. According to the predominance of a distinct cell type, fibrous hamartoma of infancy cannot be regarded as a hamartomatous lesion but should be included in the group of juvenile fibromatoses under the term ‘infantile subcutaneous myofibroblastoma

ISSN:1018-8665    

DOI:10.1159/000248669

出版商:S. Karger AG    

年代:1988

数据来源: Karger

ISSN:1018-8665    

DOI:10.1159/000248670

出版商:S. Karger AG    

年代:1988

数据来源: Karger

ISSN:1018-8665    

DOI:10.1159/000248671

出版商:S. Karger AG    

年代:1988

数据来源: Karger