摘要:

Routine cervical smears (n= 262) from a Sexually Transmitted Diseases clinic were screened by non‐isotopic in situ hybridization (NISH) stratifying human papillomavirus (HPV) infections into HPV6/11 (low risk) and HPV16/18/33 (high risk) categories. of 188 patients with cytologically normal smears, HPV sequences were demonstrated in 41%. of the 128 cases analysed by dual NISH, 16% contained low risk, 20% high risk and 5% both groups. In patients with cytological evidence of wart virus infection (WVI) only, 54% (n=50) contained high‐risk and 22% low‐risk HPV types. the comparable incidences in CIN1/2 plus WVI (n= 24) were not significantly different: 54% and 17%, respectively. Cytological criteria underestimate the prevalance of HPV infection in patients with cytologically normal smears. This represents either ‘occult’ or ‘latent’ infection. the identical prevalence of HPVB16/18/33 in WVI only, and CIN1/2 plus WVI, suggests that the cytopathic effect induced by these HPVs may represent one end of a spectrum of morphological change which progresses to cervical intraepithelial ne

ISSN:0956-5507    

DOI:10.1111/j.1365-2303.1992.tb00028.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

Death certificates were reviewed and 57 women were identified whose primary cause of death was cervical cancer. Their cervical smear records were reviewed from laboratory files. Only nine had participated in the cervical cancer screening programme before the diagnosis of cervical cancer was made. One woman had an abnormal smear as a result of cervical screening but failed to attend for follow‐up.The problem of false negative smears is also addressed and the value of review of negative smears for the purposes of cytology audit is emphasize

ISSN:0956-5507    

DOI:10.1111/j.1365-2303.1992.tb00029.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

Women with cervical smears showing borderline nuclear abnormality (BNA), or reactive changes in the form of squamous metaplasia (SM) or endocervical cell hyperplasia (ECH), were age‐matched with healthy controls to determine the outcome of these conditions. No significant difference in the risk of dyskaryosis was observed in cases showing reactive changes and the controls. In contrast, there was a 23% excess of cases showing dyskaryosis in the repeat smears of cases of BNA over the controls. an odds ratio of 8.3 was obtained, showing dyskaryosis in subsequent smears after a diagnosis of BN

ISSN:0956-5507    

DOI:10.1111/j.1365-2303.1992.tb00030.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

The possible contribution of the silver colloid technique for staining nucleolar organizer regions in the distinction between benign and malignant adrenocortical neoplasms was investigated. Nine cases of adenoma, eight cases of carcinoma, nine cases of hyperplasia and four normal adrenal cortex specimens were examined. the mean silver binding nucleolar organizer region (Ag‐NOR) value in adenoma was 4.29, and in carcinoma 7.16 (P3 cm had significantly higher Ag‐NOR counts than smaller adenomas. For normal cortex, the mean Ag‐NOR value was 2.05 and in hyperplasia, 3.62. the results indicate that the Ag‐NOR technique can help in differential diagnosis between benign and malignant adrenocortical lesions and thus may have a prognosti

ISSN:0956-5507    

DOI:10.1111/j.1365-2303.1992.tb00031.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

Occasionally, in fine‐needle aspirates of pleomorphic salivary gland adenomas, considerable cytonuclear atypia is present, which may give rise to a false‐positive diagnosis. In this study DNA cytophotometry was performed on Feulgen restained smears prepared from material obtained by needle aspirates of normal salivary glands (n= 4), pleomorphic adenomas with (n= 5) and without (n=4) atypia and a carcinoma in a pleomorphic adenoma. the results showed a clear diploid DNA histogram in the specimens of normal salivary gland and pleomorphic adenomas without atypia. In contrast, in the pleomorphic adenomas with atypia a distinct polyploid pattern was present in three out of the five DNA histograms with DNA values in 2c, 4c and 8c ranges. In two of these cases a 16c peak was also present and in the two remaining cases tetraploidy was demonstrated. In the carcinoma a main stemline at 4c was found. This report once more emphasizes the possible atypia which may be present in FNA of pleomorphic adenomas of the salivary gland. the atypia is due to polyploidy in a histologically benign tum

ISSN:0956-5507    

DOI:10.1111/j.1365-2303.1992.tb00032.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

Cytospin preparations were made from 102 serous effusions for immunocytochemical staining using a panel of monoclonal antibodies including a new monoclonal antibody Ber‐EP4. On cytological examination, 32 fluids were reported to contain tumour cells consistent with metastatic adenocarcinoma; 66 contained benign cells only and three were reported to contain cells suspicious of malignancy. One eifusion contained tumour cells consistent with malignant mesothelioma. Positive staining of the tumour cells with Ber‐EP4 was observed in the 32 effusions (100%) which contained adenocarcinoma cells. No staining of the mesothelial cells in these 32 specimens was observed. Carcinoembryonic antigen, epithelial membrane antigen Ca2 and CD 15 staining of tumour cells was noted in 53%, 50%, 50% and 9% of these cases, respectively. None of the mesothelial cells in the benign effusions stained with Ber‐EP4. Nor did the malignant mesothelial cells in the only case of malignant mesothelioma. These findings suggest that Ber‐EP4 is a valuable addition to antibodies available for the differential diagnosis of mesothelial cells and adenocarcinoma cells in serous ef

ISSN:0956-5507    

DOI:10.1111/j.1365-2303.1992.tb00033.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

Fine‐needle aspiration (FNA) is a well‐recognized technique for sampling solid organs. It is used in renal transplantation to clarify the cause of a poorly functioning graft. Differential scoring techniques with respect to peripheral blood cell populations, and immunocyto‐chemistry have been employed in this context. We describe the use of simple morphological criteria alone in renal transplant FNA. We compare these with needle biopsy and clinical parameters and show their value in the detection of active cellular rejection. Their limitations are discussed within the framework of other patterns of transplant path

ISSN:0956-5507    

DOI:10.1111/j.1365-2303.1992.tb00034.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

We report a case of sacrococcygeal chordoma initially diagnosed by fine‐needle aspiration cytology. the value of awareness by cytopathologists of the histology of soft tissue tumours is emphasize

ISSN:0956-5507    

DOI:10.1111/j.1365-2303.1992.tb00035.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

Books review in this article:Practical Histochemistry. 2nd edn. Chayen&BitenskyA Colour Atlas of Breast Pathology. M. Trojani

ISSN:0956-5507    

DOI:10.1111/j.1365-2303.1992.tb00036.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

ISSN:0956-5507    

DOI:10.1111/j.1365-2303.1992.tb00037.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY