摘要:

An overview of studies attempting to define the natural history of carcinomain situof the cervix suggests that 20–30% of lesions progress to invasive carcinoma within 5–10 years. This risk of invasion and the inability to predict when invasion might occur has been reinforced by a judicial enquiry in New Zealand so that protocols that include withholding treatment are no longer justifiable. Once a diagnosis of cervical carcinomain situis established appropriate treatment is mandat

ISSN:0956-5507    

DOI:10.1111/j.1365-2303.1990.tb00369.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

In a prospective study 42 women, diagnosed as having low grade cervical intraepithelial neoplasia (CIN), made a total of 281 clinic visits over a 45 month period. At each visit, they were subjected to cytological and colposcopical examination and samples were taken for human papillomavirus (HPV) DNA hybridization studies and for the detection of non‐HPV infections. HPV types 16 and/or 18 were found in 25% of all the samples tested and these virus types were detected in five of six (83%) women whose lesions progressed compared to seven of 14 (50%) of those whose lesions regressed. The presence of HPV DNA was not a good prognostic indicator of progression since half of those whose disease regressed also harboured these viruses at some time. The recording of non‐HPV infections almost 10 times more often in the women whose disease regressed than in those whose disease progressed could probably be accounted for by the former having a larger number of follow‐up visits. Nevertheless, the significance of non‐HPV infections also remains

ISSN:0956-5507    

DOI:10.1111/j.1365-2303.1990.tb00370.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

Oestrogen receptor immunocytochemical assay (ER‐ICA) was used to determine oestrogen receptor (ER) content of cells in fine needle aspirate (FNA) specimens from 88 breast carcinomas. In 49 of these the radioligand binding assay for oestradiol was available for comparison. The predictive value of ER‐ICA staining for a positive radioligand binding assay (greater than 10 fmol/mg protein) was 95%. Although the predictive value of negative staining was only 66%, 34 out of 37 ER‐ICA negative tumours had radioligand binding assays below 60 fmol/mg protein.ER‐ICA staining showed a strong positive correlation with age of the patient, positivity being rare before the menopause. There was a weak inverse correlation with tumour grade but none with tumour size or lymph node status.The assessment of ER by immunocytochemistry using FNA cytology is a rapid technique, which may easily be repeated and provides a pre‐operative assessment of ER status. It allows confirmation that tumour cells are present in the sample and an assessment of tumour hete

ISSN:0956-5507    

DOI:10.1111/j.1365-2303.1990.tb00371.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

In an attempt to discover the morphometric variables with the most diagnostic power in the differentiation of benign from malignant breast disease, 20 unequivocally benign and 20 unequivocally malignant and histologically confirmed breast aspirates were examined on an image analyser. It was found that standard deviation of nuclear area was the most discriminant variable. Then 23 aspirates initially diagnosed as ‘suspicious of malignancy’ were measured by the same technique, and standard deviation of nuclear area correctly differentiated all but three ca

ISSN:0956-5507    

DOI:10.1111/j.1365-2303.1990.tb00372.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

A case of gynaecomastia examined by fine needle aspiration cytology is reported. The pitfalls in trying to obtain a cytological diagnosis in the florid proliferative stage of the disease are detailed together with an account of the natural history.

ISSN:0956-5507    

DOI:10.1111/j.1365-2303.1990.tb00373.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

A pseudoepithelial pattern was observed in smears prepared from fine needle aspirates (FNA) from three plasmacytomas. In one case cells displayed a markedly granular, ‘oncocytic’ cytoplasm. Granularity of the cytoplasm was due to a large number of mitochondria as shown by electron microscopy. B‐lymphocytic origin of the neoplasms was confirmed by immunocytochem

ISSN:0956-5507    

DOI:10.1111/j.1365-2303.1990.tb00374.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

ISSN:0956-5507    

DOI:10.1111/j.1365-2303.1990.tb00375.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

ISSN:0956-5507    

DOI:10.1111/j.1365-2303.1990.tb00376.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY