ISSN:0956-5507    

DOI:10.1111/j.1365-2303.1992.tb00509.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

The influence of Tamoxifen on the vaginal epithelium of 33 premenopausal and 99 post‐menopausal women with primary advanced breast cancer was investigated. the karyopyknotic index (KPI) values were assessed before starting therapy and at monthly intervals during therapy with Tamoxifen. A decrease in the KPI in menstruating women and a slight but definite increase in KPI values in post‐menopausal women were obser

ISSN:0956-5507    

DOI:10.1111/j.1365-2303.1992.tb00510.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

This study was conducted on fine‐needle aspirates of well differentiated follicular neoplasms of the thyroid. A ‘decision tree’classification based on the percentage of nucleolated nuclei, percentage of nuclei with two or more nucleoli and mean major nuclear diameter was adopted. We observed that the reproducibility and the validity of the follicular adenoma vs follicular carcinoma discrimination are greater than in the subjective evaluation. Moreover, similar classification results were obtained when measurements were performed either with a fully automated image analysis system or with semiautomatic or manual instrumentation. As for reproducibility of the inter‐instrument comparisons, the k statistic values ranged from 0.85 to 1.00 (mean value 0.90, that is, an ‘almost perfect’degree of agreement); in the subjective evaluations, the inter‐observer comparisons showed values ranging from 0.20 to 0.56 (mean value 0.37, that is, ‘fair’). In the decision tree classification, feature value thresholds were selected in order to have specificity of 100% and the predictive value of a positive result (carcinoma) of 100%; accuracy was 87% (range 86–89%), sensitivity 74% (71–79%), the predictive value of a negative result (adenoma) 79% (78–82%). In the subjective evaluation the values were as follows: accuracy 67% (64–71%), sensitivity 57% (50–64%), specificity 77% (71–79%), predictive value of a negative result (adenoma) 64% (61–69%), predictive value of a positive result (carcinoma) 71% (67–75%). the conclusion is that, by using a routine microscope equipped with a micrometer, the preoperative diagnosis of follicular carcinoma from smears can be formulate

ISSN:0956-5507    

DOI:10.1111/j.1365-2303.1992.tb00511.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

Nucleolar organizer regions are DNA segments concerned with the synthesis of ribosomal RNA (rRNA). Some specific proteins related to NORs can be demonstrated by a silver technique and are then referred to as Ag‐NORs. the mean number of Ag‐NORs per cell has been used as a marker of cell proliferation in recent years and there is some evidence to suggest that Ag‐NOR counts can be used to differentiate between normal and neoplastic cells.Paraffin block sections of 42 pituitary gland adenomas and 24 normal adult pituitary glands have been examined using the Ag‐NOR staining technique. Touch imprints of nine adenomas and 12 normal adult pituitary glands were also examined using the same Ag‐NOR staining technique. Using light microscopy at x 2000 magnification, the Ag‐NORs were located as black dots in the cell nuclei and the mean number of Ag‐NORs per cell was determined. No significant difference was observed between blocked sections and imprints of adenomas or between imprints and paraffin sections of normal glands. However, a significant difference was observed between the mean number of Ag‐NORs in pituitary gland adenomas and normal glands in paraffin block sections and touch preparations (P<0.001). the modified Ag‐NOR technique can be a useful aid in the differential diagnosis between normal pituitary gland tissue and pituitary adenomas, especially during su

ISSN:0956-5507    

DOI:10.1111/j.1365-2303.1992.tb00512.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

We have studied 12 cutaneous vascular tumours by means of fine‐needle aspiration cytology (FNAC): six capillary haemangiomas, one cavernous haemangioma, one Masson's pseudoangiosarcoma, two angiosarcomas, one benign haemangioendothelioma and one glomus tumour. We describe the main cytopathological findings and we discuss the differential diagnosis in each case. We consider that the cytopathological findings of the above lesions, evaluated in the context of the clinical findings, are sufficiently characteristic for us to be able to make a definitive diagnosis. We believe that FNAC can play an important part in the diagnosis and therapeutic planning of these tumour

ISSN:0956-5507    

DOI:10.1111/j.1365-2303.1992.tb00513.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

This report describes the cytological and histological features of a leiomyosarcoma of the breast. the differential diagnosis of this rare tumour is discussed. Eleven well documented cases of leiomyosarcoma of the breast have been reported previously and details of these are included in this review.

ISSN:0956-5507    

DOI:10.1111/j.1365-2303.1992.tb00514.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

Solitary papillomas of the lung are rare. They are usually squamous but mixed squamous cell papilloma and mucous gland adenoma can occur. We report for the first time the Cytological findings of a fine needle aspirate from a mixed squamous cell papilloma and mucous gland adenoma from the lung periphery.

ISSN:0956-5507    

DOI:10.1111/j.1365-2303.1992.tb00515.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

Mucoepidermoid carcinoma of the lung is a rare tumour, and is not usually considered in the differential diagnosis of a peripheral lung mass. the cytological and histological features of an intimate admixture of polygonal intermediate cells, well differentiated mucinous and squamous cells, as illustrated in this case report, serve to differentiate a well differentiated mucoepidermoid carcinoma from adenosquamous carcinoma, low grade adenocarcinoma, bronchioloalveolar carcinoma, and benign reactive changes.

ISSN:0956-5507    

DOI:10.1111/j.1365-2303.1992.tb00516.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY