|
1. |
The Evaluation and Interpretation of Cervical Cytology: Application of the Likelihood Ratio Concept |
|
Cytopathology,
Volume 4,
Issue 3,
1993,
Page 131-137
R. W. M. GIARD,
J. HERMANS,
Preview
|
PDF (421KB)
|
|
摘要:
The Papanicolaou smear (Pap test), used for the detection and prevention of neoplastic lesions of the cervix, is known to have both false negative and false positive results. Proper handling of the diagnostic uncertainty resulting from these errors demands quantification of flaws. Traditionally, sensitivity, specificity and predictive values are used for that aim. In this study another approach is advocated, namely the use of the likelihood ratio. For cervical cytology this ratio is the quotient of the probability of a Pap class within the diseased population to the probability of that same Pap class within the non‐diseased group. This approach enables the characterization of each Pap class separately, and is therefore much better for clinical interpretation of the result. It is also a superior approach for quality assessmen
ISSN:0956-5507
DOI:10.1111/j.1365-2303.1993.tb00078.x
出版商:Blackwell Publishing Ltd
年代:1993
数据来源: WILEY
|
2. |
Laboratory Test of an Automated Cell Analysis System For Cervical Screening |
|
Cytopathology,
Volume 4,
Issue 3,
1993,
Page 139-147
R. STROHMEIER,
H. NAUJOKS,
A. M. J. DRIEL‐KULKER,
J. S. PLOEM,
Preview
|
PDF (576KB)
|
|
摘要:
An automated cell analysis system (Autoplan‐MIAC) for the early detection of precancerous lesions of the cervix was tested under semi‐routine conditions in a clinical cytology laboratory. A set of 1500 specimens, highly enriched with abnormal cases, was analysed. Cervical scrapings were collected in suspension and processed by cytocentrifugation for microscopy. Two slides were prepared from each sample: one for staining according to Papanicolaou for the visual reference diagnosis and one for Feulgen staining for automated analysis. the specimens were evaluated in two ways: the first one, which is referred to as the automated machine classification system (AMC), classifies the specimens according to the number and ratio of selected objects (alarms) and is a fully automated system. the second system classifies the specimens after visual evaluation of the stored alarms as they are displayed on a TV monitor, and is designated the interactive machine classification system (IMC). the AMC results showed a false positive rate of 16.5% when the cut‐off threshold was selected so that all 117 positively diagnosed specimens were classified ‘positive’ by the system. In that case 87.4% of the CINI and 96.9% of the CINII cases were AMC‐positive. the IMC results showed a false positive rate of 2.5%, when 86.3% of the CIN I cases, 96.9% of the CIN II cases and all CIN III and invasive carcinoma cases were positively
ISSN:0956-5507
DOI:10.1111/j.1365-2303.1993.tb00079.x
出版商:Blackwell Publishing Ltd
年代:1993
数据来源: WILEY
|
3. |
Ciliary Ultrastructure In Nasal Brushings |
|
Cytopathology,
Volume 4,
Issue 3,
1993,
Page 149-159
A. M. ROBSON,
L. A. SMALLMAN,
J. GREGORY,
A. B. DRAKE‐LEE,
Preview
|
PDF (731KB)
|
|
摘要:
Normal ciliary ultrastructure is thought to be necessary for effective function. There has been little or no attempt to quantify ultrastructural abnormalities in nasal disease and assess their significance. In this study we measured nasal ciliary function and examined ciliary ultrastructure in nasal brushings from 35 patients with perennial nasal symptoms refractory to treatment. Ultrastructural defects included microtubular abnormalities, compound cilia and ciliary ‘blebs’. the incidence of abnormal cilia was 16.7%, compared with 9% in controls, but there was only a poor correlation between ultrastructural defects and ciliary beat frequency. One patient had primary ciliary dyskinesia (PCD) with a typical clinical history and immotile cilia. However, only secondary ultrastructural abnormalities were seen. We have been unable to show that ciliary ultrastructural defects form the basis of impaired function. In patients with suspected PCD, nasal brushings should be taken for functional and ultrastructural studies; ideally, a further sample should be obtained for examination of possible primary ultrastructural abnormalit
ISSN:0956-5507
DOI:10.1111/j.1365-2303.1993.tb00080.x
出版商:Blackwell Publishing Ltd
年代:1993
数据来源: WILEY
|
4. |
Evidence That the Sensitivity Is Increased and the Inadequacy Rate Decreased When Pathologists Take Aspirates For Cytodiagnosis |
|
Cytopathology,
Volume 4,
Issue 3,
1993,
Page 161-165
A. F. PADEL,
S. B. COGHILL,
S. J. A. POWIS,
Preview
|
PDF (329KB)
|
|
摘要:
The results of the diagnostic accuracy of breast fine needle aspiration specimens taken by the pathologist in a joint surgical clinic are compared with those taken by a surgeon. In the joint clinic the complete sensitivity rose by 15% and the number of missed malignancies fell by half.
ISSN:0956-5507
DOI:10.1111/j.1365-2303.1993.tb00081.x
出版商:Blackwell Publishing Ltd
年代:1993
数据来源: WILEY
|
5. |
A Case of Pilomatrixoma Misdiagnosed As Squamous Cell Carcinoma |
|
Cytopathology,
Volume 4,
Issue 3,
1993,
Page 167-171
W. KINSEY,
S. B. COGHILL,
Preview
|
PDF (379KB)
|
|
ISSN:0956-5507
DOI:10.1111/j.1365-2303.1993.tb00082.x
出版商:Blackwell Publishing Ltd
年代:1993
数据来源: WILEY
|
6. |
Cytological Features of Epithelial‐Myoepithelial Carcinoma of Salivary Gland: Potential Pitfalls In Diagnosis |
|
Cytopathology,
Volume 4,
Issue 3,
1993,
Page 173-180
G. KOCJAN,
C. MILROY,
E. W. FISHER,
J. W. EVESON,
Preview
|
PDF (625KB)
|
|
ISSN:0956-5507
DOI:10.1111/j.1365-2303.1993.tb00083.x
出版商:Blackwell Publishing Ltd
年代:1993
数据来源: WILEY
|
7. |
Prolapsed Fallopian Tube After Abdominal Hysterectomy: A Report of the Cytological Findings |
|
Cytopathology,
Volume 4,
Issue 3,
1993,
Page 181-185
E. A. HELLEN,
S. B. COGHILL,
J. V. CLARK,
Preview
|
PDF (413KB)
|
|
ISSN:0956-5507
DOI:10.1111/j.1365-2303.1993.tb00084.x
出版商:Blackwell Publishing Ltd
年代:1993
数据来源: WILEY
|
8. |
Correspondence: Adequacy of Cervical Smears |
|
Cytopathology,
Volume 4,
Issue 3,
1993,
Page 187-188
D. SLATER,
Preview
|
PDF (150KB)
|
|
ISSN:0956-5507
DOI:10.1111/j.1365-2303.1993.tb00085.x
出版商:Blackwell Publishing Ltd
年代:1993
数据来源: WILEY
|
9. |
Postscript |
|
Cytopathology,
Volume 4,
Issue 3,
1993,
Page 188-188
J. JOHNSON,
Preview
|
PDF (70KB)
|
|
ISSN:0956-5507
DOI:10.1111/j.1365-2303.1993.tb00086.x
出版商:Blackwell Publishing Ltd
年代:1993
数据来源: WILEY
|
10. |
News pages |
|
Cytopathology,
Volume 4,
Issue 3,
1993,
Page 189-189
Preview
|
PDF (156KB)
|
|
ISSN:0956-5507
DOI:10.1111/j.1365-2303.1993.tb00087.x
出版商:Blackwell Publishing Ltd
年代:1993
数据来源: WILEY
|
|