ISSN:0956-5507    

DOI:10.1111/j.1365-2303.1995.tb00450.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

摘要:

Early detection and eradication of cervical cancer and its precursor lesions through organized mass cytological screening programmes have recently gained considerable attention in developing countries. Strategies for both cost saving and effective implementation are however required for mass cervical screening in developing countries. In an early cancer detection programme conducted in South India, we analysed cytological abnormalities in 3602 women and correlated the results with other factors, including age, gynaecological complaints, number of years of married life and parity to see if pre‐selection for cytologic screening was possible. Only lower grades of dysplasia were found in asymptomatic women below the age of 40 years. In asymptomatic women, malignancy and higher grades of dysplasia were confined to women with a clinically abnormal cervix only. Univariate analysis also revealed that subjects with a parity of more than 3 and a married life of more than 20 years had a significantly higher number of cytological abnormalities. However, on a multivariate analysis the increased number of marital years was not found to be an independent variable. These results suggest that asymptomatic women below the age of 40 years with a married life of less than 20 years and parity below 3, may be excluded from screening campaigns, and that pre‐selection for cytologic screening is possible by introducing a programme of clinical and speculum examination of the cer

ISSN:0956-5507    

DOI:10.1111/j.1365-2303.1995.tb00451.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

摘要:

This study evaluates the feasibility of DNA analysis of cervical intraepithelial neoplasia III (CIN III) lesions on cervical smear and formalin‐fixed paraffin‐embedded tissue (FFPET) blocks with a view to extending this type of analysis to milder grades of dyskaryosis. DNA ploidy was determined by image analysis using a CAS 200 Image Analyser. Seventeen patients with a diagnosis of CIN III were studied. Results show that all smear and tissue samples were non‐diploid with nine aneuploid and eight tetraploid lesions. In 6/7 patients whose smears and corresponding biopsies were examined there was complete agreement as to the DNA profile. We conclude that DNA quantification is technically feasible in archival, routinely prepared cervical smears. This technique should now be applied to CINI and CINII cervical smears to determine if it is of value in identifying those lesions that will progress to CIN III. This study is particularly timely with the possibility in the near future of estimation of ploidy by image analysis using instruments such as the Highly Optimized Microscope Environment (HOME) s

ISSN:0956-5507    

DOI:10.1111/j.1365-2303.1995.tb00452.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

摘要:

Rapid rescreening of approximately 30% of all negative and inadequate consecutive smears was carried out over a 26‐month period. Smears (n = 24012) were rescreened using a × 6.3 objective only. Two minutes were allowed for each slide. Thirty‐nine smears were found to have been incorrectly diagnosed as negative, a rate of 0.16%. This can be compared with the previous 26 months during which the traditional 1 in 10 random rescreening of unsatisfactory and negative smears had been carried out at a routine pace and with an objective of × 10. A total of 6866 smears were rescreened. Eleven were found to have been incorrectly diagnosed as negative, a rate of 0.16%. Rapid rescreening is as sensitive as 1 in 10 rescreening, and allows a greater proportion of smears to be rescreened. We propose rapid rescreening should replace the traditional 1 in 10 rescreening me

ISSN:0956-5507    

DOI:10.1111/j.1365-2303.1995.tb00453.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

ISSN:0956-5507    

DOI:10.1111/j.1365-2303.1995.tb00454.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

ISSN:0956-5507    

DOI:10.1111/j.1365-2303.1995.tb00455.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

ISSN:0956-5507    

DOI:10.1111/j.1365-2303.1995.tb00456.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

ISSN:0956-5507    

DOI:10.1111/j.1365-2303.1995.tb00457.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

ISSN:0956-5507    

DOI:10.1111/j.1365-2303.1995.tb00458.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

ISSN:0956-5507    

DOI:10.1111/j.1365-2303.1995.tb00459.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY