摘要:

Oestrogen receptor (ER) status of 77 cases of screen‐detected breast cancer has been determined using cytological preparations. In 48% ER status was positive, which was the same proportion as that formed in a control group of age‐matched patients with symptomatic breast carcinoma. Since the screen‐detected group contained more low grade tumours, the percentage of ER‐positive cases would be expected to be higher. the reasons for the discrepancy are discussed. Ki67 score has been determined for 41 cases of screen‐detected cancer. Ki67 score showed a positive correlation with histological tumour grade and a negative correlation with ER status. However, there was no correlation with tumour size or lymph node status. the Ki67 scores in the screen‐detected cancers were essentially similar to those found in an age‐matched symptomatic group, but the very low scores were only found in the s

ISSN:0956-5507    

DOI:10.1111/j.1365-2303.1993.tb00100.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

摘要:

Commercially available monoclonal antibodies AUA1, BER EP4 and carcinoembryonic antigen (CEA) were applied to cell blocks from 95 serous effusions. AUA1 and BER EP4 were reactive with 89% of effusions known to contain carcinoma cells, and anti‐CEA with 71%. They also reacted with cells in two effusions from patients with malignant disease which were regarded as negative on conventional cytological examination of Papanicolaou‐stained smears. They were negative in all but one of the benign effusions. Using all three antibodies, 95% of effusions containing carcinoma cells were detected. Use of these antibodies could improve the cytological diagnosis of serous effusi

ISSN:0956-5507    

DOI:10.1111/j.1365-2303.1993.tb00101.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

摘要:

Human papillomavirus (HPV) infection in the genital tract is associated with a number of cytological changes which are accepted as standard criteria for a cytological diagnosis. We evaluated the covariation and diagnostic accuracy of these criteria in 210 patients, i.e. 150 cases who were positive for HPV types 6, 11, 16, 18, 31, 33 or 35, and 60 cases who were HPV‐negative by simultaneous Southern blot analysis. This was done by re‐examining cervical smears obtained at the same time, without knowing the results of the Southern blot analysis, for the presence of koilocytosis, dyskeratosis‐parakeratosis, nuclear smudging, hyperchromasia, binucleation, multinucleation, karyorrhexis and macrocytosis. We found that all these cytological changes correlated with the presence of an HPV infection. However, analysis of variance showed that koilocytosis, dyskeratosis‐parakeratosis and karyorrhexis were of particular diagnostic value, while the other features provided little or no additional information. By omitting these features and making the diagnosis when two out of three of the key criteria, i.e. koilocytosis, dyskeratosis‐parakeratosis and karyorrhexis were present, we diagnosed HPV infection with a specificity of 100% in 36% of the 150 cases, which were positive by Southern blot analysis. the various HPV types produced different morphological patterns which may reflect differences in action on the host cell. In the individual patient, however, such differences in cytology do not provide a sound basis for distinguishing between vi

ISSN:0956-5507    

DOI:10.1111/j.1365-2303.1993.tb00102.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

摘要:

A matched case‐control study of 123 false negative Papanicolaou smears and 488 true negative Papanicolaou smears was undertaken to determine the association between the types of cells present on the smear and the correctness of the cytology report. the false negative slides were significantly more likely to include endocervical columnar cells than the true negative slides (odds ratio 1.90, 95% confidence interval (CI) 1.21–3.01). No statistically significant difference in metaplastic cell status was evident (odds ratio 1.48, 95% CI 0.95–2.30). When considered together, metaplastic and/or columnar cells were significantly more likely to be present in false negative smears than in true negative smears (odds ratio 1.87, 95% CI 1.13–3.08). the implications of these findings for improving the accuracy of cervical cytology for the detection of precancerous lesions are di

ISSN:0956-5507    

DOI:10.1111/j.1365-2303.1993.tb00103.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

摘要:

Fine needle aspiration (FNA) was performed on 102 hepatic lesions under ultrasound control. Eighty‐eight lesions were solid and 14 were cystic. Ninety aspirates provided adequate material for cytodiagnosis. Aspirates from the solid lesions were assessed for the presence or absence of 20 cytological features. It was found that on a univariate statistical analysis, 11 of the features were significantly associated with hepatocellular carcinomas. Five of these 11 were considered diagnostic of the lesion on a step‐wise multiple linear regression analysis. Two other features (not included among the 11) were found to be significantly associated with metastatic neoplasms. Cystic lesions were diagnosed as being either abscesses, hydatid cysts or congenital cysts. the physical appearance of the cyst fluid proved to be of diagnostic value in many ca

ISSN:0956-5507    

DOI:10.1111/j.1365-2303.1993.tb00104.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

摘要:

Fine needle aspiration (FNA) and non‐suction fine needle sampling (FNS) were performed consecutively in 107 lesions from 100 patients. the quality of diagnostic material was assessed using a scoring system based on the cellularity and amount of blood in the smear. the total score in the FNS group was significantly higher (P<0.05) than that of FNA technique. the FNS procedure is less traumatic and equally cost effective and can be safely undertaken in liver, orbital and thyroid lesions. In lymph nodes, especially in children, FNS gives an excellent cellular yield. However, this procedure can not be advocated in cystic, bony and fibrous lesion

ISSN:0956-5507    

DOI:10.1111/j.1365-2303.1993.tb00105.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

ISSN:0956-5507    

DOI:10.1111/j.1365-2303.1993.tb00106.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

ISSN:0956-5507    

DOI:10.1111/j.1365-2303.1993.tb00107.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

ISSN:0956-5507    

DOI:10.1111/j.1365-2303.1993.tb00108.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

ISSN:0956-5507    

DOI:10.1111/j.1365-2303.1993.tb00109.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY