摘要:

pS2 protein is a cysteine‐rich polypeptide, of unknown function, the expression of which is induced in the human cancer cell line MCF‐7 by oestrogen. the availability of a murine monoclonal antibody to human pS2 protein has prompted us to evaluate its expression in 47 cases of primary breast carcinoma. Using a double indirect immunoperoxidase technique, we compared the expression of pS2 protein in fine needle aspiration (FNA) cytology smears with that in formalin‐fixed, paraffin‐embedded sections from subsequently excised tumours from the same patients. We also compared the expression of pS2 protein and oestrogen receptor (ER) status using immunocytochemical assay (ER‐ICA) in formalin‐fixed, paraffin‐embedded sections from 22 primary breast carcinomas. We found the application of immunocytochemistry in the assessment of pS2 protein expression in FNA cytology to be a reliable and cost‐effective technique, having a sensitivity of 84% and a specificity of 100%. There was also a good correlation between the expression of pS2 protei

ISSN:0956-5507    

DOI:10.1111/j.1365-2303.1993.tb00110.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

摘要:

This report investigates the reasons for false negative cervical cytology in 94 out of 630 patients (15%) in whom cervical intraepithelial neoplasia (CIN) was diagnosed on colposcopically directed biopsy. Cervical smears were taken immediately before biopsy and the cases with false negative cytology were compared with those whose cytology was abnormal. Patients with false negative cytology were more likely to have been younger (P<0.01), to have had fewer pregnancies (P<0.001), to have had a less severe grade of dyskaryosis on their referral smear (P<0.001), to have had no endocervical cells on the smear (P<0.05), to have had a less severe grade of CIN on biopsy (P<0.001), to have had no punctation visible at colposcopy (P<0.01), and to have had no mosaic pattern seen at colposcopy (P<0.05). We found no effect attributable to the patient's menstrual history, the interval between referral smear and colposcopy clinic visit, the smear taker or the type of spatula used to take the smear.

ISSN:0956-5507    

DOI:10.1111/j.1365-2303.1993.tb00111.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

摘要:

The cervical cytology and histology specimens from 200 patients referred to colposcopy with borderline nuclear abnormality were reviewed. Human papillomavirus (HPV)‐associated changes were identified in 103 of 200 (53%) referral smears and in 139 of 150 (91%) biopsy specimens. Cervical intraepithelial neoplasia (CIN) was less frequently diagnosed on review compared with the original histopathology reports (30.7%vs45.4%); the discrepancy was largely attributable to a lower incidence of CINI. There was agreement in the grading of borderline nuclear abnormality in 161 of 200 referral smears following review. Twenty‐three smears were upgraded to mild dyskaryosis, whereas 16 were reclassified as negat

ISSN:0956-5507    

DOI:10.1111/j.1365-2303.1993.tb00112.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

摘要:

Impression cytology is a simple and painless procedure that allows the collection of the superficial layers of the conjunctival epithelium. Each sample is assigned a grade of epithelial metaplasia, and goblet cell density is calculated in each one. We have studied the superior and temporal bulbar conjuctiva of dry eyes and have compared it with that of normal controls. In normal and dry eyes we find a statistically significant difference both in goblet cell density and grade of metaplasia, between superior and temporal bulbar conjunctiva. the differences in grade of metaplasia and goblet cell density between normal and dry eyes are significant in the superior conjunctiva, but in the temporal conjunctiva we only find significant differences in grade of metaplasia.

ISSN:0956-5507    

DOI:10.1111/j.1365-2303.1993.tb00113.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

ISSN:0956-5507    

DOI:10.1111/j.1365-2303.1993.tb00114.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

ISSN:0956-5507    

DOI:10.1111/j.1365-2303.1993.tb00115.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

ISSN:0956-5507    

DOI:10.1111/j.1365-2303.1993.tb00116.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

ISSN:0956-5507    

DOI:10.1111/j.1365-2303.1993.tb00117.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

ISSN:0956-5507    

DOI:10.1111/j.1365-2303.1993.tb00118.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY

ISSN:0956-5507    

DOI:10.1111/j.1365-2303.1993.tb00119.x

出版商:Blackwell Publishing Ltd    

年代:1993

数据来源: WILEY