摘要:

SummaryFatal hepatic coma complicating oxymetholone therapy in multiple myeloma. G. P. Young, P. S. Bhathal, J. R. Sullivan, A. J. Wall, D. J. Fone and T. H. Hurley,Aust. N.Z. J. Med,1977,7, pp. 47–51.Two patients with multiple myeloma died in acute liver failure. Both had been treated with the anabolic steroid oxymetholone and both subsequently developed severe cholestatic hepatitis. In one the histological lesion progressed despite cessation of oxymetholone therapy. Myeloma infiltration of the liver and peliosis hepatis were not seen. As a fatal outcome from cholestatic hepatitis due to oxymetholone is rare it is possible that an unknown potentiating factor is present in multiple myeloma that can lead to a fatal outcome. If oxymetholone therapy is to be used in such patients then close clinical and laboratory assessment of liver function should be carried out in an attempt to prevent this unusual and fatal complicatio

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1977.tb03356.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

SummaryEndoscopic diagnosis of metastatic disease of the stomach and duodenum. G. P. Coughlin, A. J. Bourne and A. Kerr Grant,Aust. N.Z. J. Med.,1 977,7, pp. 52–55.The commonest tumours which metastasise to the upper gastrointestinal tract are from malignant melanoma, carcinoma of the breast and lung. Over a period of 12 months, three persons with known malignant disease were submitted to endoscopy by reason of upper gastrointestinal symptoms which could have been due to associated non‐malignant disease. Two patients had known malignant melanoma and one a carcinoma of the breast. In each instance, endoscopy and biopsy demonstrated evidence of metastatic dise

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1977.tb03357.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

SummaryTorulopsis glabrata–Urinary tract infections in diabetic patients in Singapore. Rowland J. S. Tan, Ek‐Wang Lim and Baharudin Ishak,Aust. N.I. J. Med,1977,7, pp. 56–59.Urinary tract infections result mostly from ascending infection by micro‐organisms introduced by way of the urethra. Bacteria are the usual causative agents. Occasionally, yeasts notably Candida albicans,are involved. Females are more prone to acute infections than males because of shorter urethra and the higher risks of contamination in the

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1977.tb03358.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

SummaryMultiple myeloma with massive Bence Jones proteinuria and preservation of renal function. R. Woodruff and B. Sweet,Aust. N.Z. J. Med.,1977,7, pp. 60–62The case history of a patient having multiple myeloma with a remarkably high level of Bence Jones proteinuria (more than 20 gl day) is presented. The patient has responded well to therapy, and at no stage has he shown impairment of renal function as determined by creatinine clearance studies.A review of published reports has shown that such marked Bence Jones proteinuria at presentation is rare and is usually accompanied by renal impairment and a short survival. Additional presentation data from selected patients in the MRC First Myelomatosis Trial is presented. This suggests a higher incidence of marked Bence Jones proteinuria, and underlines the lack of correlation between the quantity excreted and the degree of renal impairment. The mechanisms by which Bence Jones protein may cause renal damage are discusse

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1977.tb03359.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

SummaryWatery diarrhoea syndrome with episodic hypercalcaemia. I. M. Holdaway, M. C. Evans and E. D. Clarke,Aust. N.Z. J. Med., 1977,7. pp. 63–65.A patient with the Watery‐Diarrhoea syndrome and episodic hypercalcaemia is reported. Plasma levels of vasoactive intestinal peptide (VIP) were elevated, and an islet cell adenoma of the pancreas was removed following which VIP levels decreased and diarrhoea ceased. During a hypercalcaemic episode, serum parathyroid hormone (PTh) levels were suppressed indicating the hypercalcaemia was independent of PTh and probably due to a direct action of VIP on calcium turno

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1977.tb03360.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

SummaryPotassium homeostasis. J. R. Stockigt,Aust. N.Z. J. Med.,1977, 7, pp. 66–77.Potassium balance is regulated by appropriate changes in potassium excretion in the distal portion of the nephron. By contrast, potassium intake, absorption and proximal renal reabsorption do not show regulatory variation. Extracellular potassium concentration, which is a critical factor in membrane polarization, may at times vary in a direction opposite to total body content, because of altered distribution across cell membranes. Alterations in acid‐base status frequently disturb homeostasis by altering potassium movement into cells, while insulin has an important regulatory effect on distribution. In general, the multiple renal and extrarenal mechanisms which prevent potassium overload are highly developed, while conservation is relatively ineffective. Consequently, depletion occurs more easily than spontaneous potassium overload. Homeostasis can be disturbed by renal impairment, excessive tissue breakdown, disturbances of acid‐base balance, abnormal routes of loss, mineralocorticoid abnormalities and aberrations of sodium ba

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1977.tb03361.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

Summary:Epidemiological bases for ambient air quality criteria. S. R. Leeder and L. D. Pengelly,Aust. N.Z. J. Med.,1977, 7, pp. 78–87.Epidemiological information about the health consequences of ambient air pollution is adequate at present to set upper limits so that acute deterioration due to pollution can be prevented in patients with chronic lung disease. However, our knowledge is incomplete with respect to what is a safe chronic background level, particularly with regard to reducing and preventing the amount of chronic respiratory disease presently occurring. This review concentrates exclusively on sulphur dioxide and particulate pollution, although the principles used in setting standards for these two pollutants may be applied to photochemical pollutants such as ozone which may affect the lung. It is only when the dose‐effect relationships between pollution and disease are more clearly understood that the benefit of reducing air pollution to improve health can be predic

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1977.tb03362.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1977.tb03363.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1977.tb03364.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1977.tb03365.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY