摘要:

Abstract:Forty‐four previously untreated Chinese adult patients with acute lymphoblastic leukemia (ALL) were treated with vincristine, adriamycin and prednisone with or without L‐asparaginase. The clinical features and prognostic factors were similar to those reported in Caucasian series. Overall complete remission (CR) rate was 52%. Duration of first remission and overall median survival were nine and 12 months respectively. The addition of L‐asparaginase did not improve CR rate or duration of remission and was associated with clotting dysfunction and other adverse reactions. Factors associated with a higher CR rate include age<40 years, blast count<10 times 109/1 and CALLA+phenotype at presentation. Sex, platelet count and FAB morphology did not affect CR rate.Bone marrow relapse occurred in 11 patients and was associated with short survival after relapse (median two months; mean two months; range 0.5–7 months). Central nervous system relapse occurred in four patients and was compatible with relatively long survival after relapse (median 13 months; mean 12 months; range 6–12 + months).The poor CR rate and short median survival in this study could not be adequately explained by an increase in risk factors and is likely to be due to what is currently regarded as suboptimal chemotherapy. (Aust NZ J Med 1989; 1

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1989.tb01672.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

Josef Stippig, Aloys Berg and Joseph Keul. CARDIAC REHABILITA TION‐OUTPA TENT PHYSICAL TRAINING METHOD

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1989.tb01673.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

Abstract:Gliclazide (80 mg bd) was administered to nine subjects with type 2 (non insulin dependent) diabetes inadequately controlled on diet only. Twenty‐four hour glucose, insulin and c‐peptide profiles were obtained before and after one week and four months of therapy. Insulin sensitivity was assessed by euglycemic hyperinsulinemic clamp before and after four months of treatment. Twenty‐four hour glucose levels were significantly lowered after one week and four months. Insulin secretion, as assessed by the areas under the insulin and c‐peptide curves, was enhanced after one week. The increase was most noted during the day in response to meals. The enhancement was maintained after four months of treatment with the increase in the postabsorptive phase becoming significant. Glucose utilisation rate was significantly increased at four months. It is concluded that both acute and prolonged gliclazide therapy directly or indirectly 1) enhances both meal stimulated and post absorptive insulin secretion and 2) increases insulin sensitivity. The relative contribution of each to improved diabetic control has not been established. (Aust NZ J Med 1989; 19:

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1989.tb01674.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

Abstract:Hypercalcemia is a common cause of morbidity in cancer patients. The mechanism of malignancy‐associated hypercalcemia includes increased bone resorption and decreased renal calcium clearance which also occur in primary hyperparathyroidism. Norethisterone can inhibit bone resorption and has recently been shown to be effective treatment for mild hyperparathyroidism in post menopausal women. We report the successful use for the first time of norethisterone (5 mg daily) in a case of malignancy‐associated hypercalcemia after other standard agents failed. (Aust NZ J Med 1989; 19: 51

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1989.tb01675.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

PHYSICAL TREATMENTS INPSYCHIATRY. By L. G. Kiloh, S. J. Smith, G. F. Johnson.

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1989.tb01676.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

Abstract:A 55‐year‐old male with chronic lymphocytic leukemia developed a skin eruption after receiving oral cyclophosphamide. Subsequent rechallenge with parenteral cyclophosphamide led to recurrence of the skin lesions, which on biopsy were shown to be vasculitic in nature. (Aust NZ J Med 1989; 19: 55

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1989.tb01677.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

PSYCHIA TRIC BIBLIOGRAPHY 1960–1984. By Johan Schioldann‐Nielsen. Odense University Press, FAMOUS AND VERY IMPORTANT PERSONS ‐ MEDICAL, PSYCHOLO

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1989.tb01678.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

AbstractA 28‐year‐old male presented with profound hypokalemia and was found to have a variant of Bartter's syndrome with nephrocalcinosis, hypercalciuria, normal distal fractional reabsorption of chloride and normal sodium delivery to the distal tubule. (Aust NZ J Med 1989; 19: 58

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1989.tb01679.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

Abstract:A male patient presented with dyspnea due to a large left pleural effusion, and pleural biopsy revealed a malignant paraganglioma. Raised urinary catecholamine levels confirmed a functioning tumour. Aggressive local spread occurred which did not respond to cytotoxic chemotherapy. The primary site of the tumour was most likely the aorticosympathetic chain. (Aust NZ J Med 1989; 19: 61–63

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1989.tb01680.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1989.tb01681.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY