摘要:

AbstractThe combination cytosine arabinoside (ara‐C), daunorubicin, and VP16–213 was studied in 28 patients with acute non‐lymphocytic leukemia to define the toxicity of the combination and assess its efficacy. Of 21 previously untreated patients, 16 (76%) achieved a complete response (CR) with the median remission duration not reached but exceeding 25 weeks. For CR patients, the median number of days with neutrophils<500/μI was 19. The median survival for patients with CR is 60 weeks. Two of seven previously treated patients achieved CR for 11 weeks and in excess of 36 weeks, respectively. At the initial VP16–213 dose of 100 mg m‐2per day for seven days, severe stomatitis was seen in 38% of courses but was less with dose reduction to 75 mg m‐2per day for seven days. Other toxicity was similar to previous experience with ara‐C and daun

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1986.tb01115.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

AbstractSerum antibodies to Ross River virus and Murray Valley encephalitis virus were measured during 1974–1975 in residents of Echuca, an urban Murray Valley community. A representative group of volunteers was obtained by random selection of households. The prevalence of antibodies to both viruses increased progressively with age. Prevalence was equal in both sexes for both viruses in all age groups, indicating that the risk of infection was mainly determined by geography rather than by personal activities. Antibody levels remained unchanged in the following year when there was no disease activity in the area. The stability of antibody levels permitted retrospective estimates of mean rates of infection. These were approximately 0.4% per annum for both viruses when age was used as the index for years of exposure. With allowance for other factors, the best estimate for both virus infections is probably closer to 1%. The morbidity rate for Ross River virus infection appeared to be low. It is concluded that infection with Ross River virus and with Murray Valley encephalitis‐related viruses is endemic in the Murray Val

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1986.tb01116.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1986.tb01117.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

AbstractThe patient described had correction of Fallot's pentalogy at the age of 61 and has been asymptomatic for a further five years. Survival with this disorder to this age is extremely rare, and successful surgery for cyanotic congenital heart disease in the seventh decade of life has apparently not been reported previously.

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1986.tb01118.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

AbstractThree cases are described of severe congestive heart failure which failed to respond to digitalis, high doses of loop diuretics, and converting‐enzyme inhibitors. The addition of spironolactone produced a substantial diuresis associated with clinical and radiological improvement in each case. Although a reversible deterioration in renal function was observed, this drug combination represents a therapeutic option in end‐stage heart fail

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1986.tb01119.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

PAEDIATRIC NEUROENDOCRINOLOGY. Edited by Derek Gupta, with Patrizia Borrelli and Andrea Attanasio

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1986.tb01120.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

AbstractTwo cases of resuscitated sudden cardiac death are described; one was due to ventricular fibrillation and the other to ventricular asystole. In both cases the underlying etiology was painless coronary spasm and no fixed coronary disease.

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1986.tb01121.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

AbstractThe first reported case of disseminated histoplasmosis in Western Australia is described. The diagnosis was delayed because the clinical presentation closely resembled that of tuberculosis, the initial histoplasma serology was negative, and constant severe thrombocytopenia delayed efforts to obtain tissue required for culture and histology. Despite adequate therapy, relapse occurred on one occasion.

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1986.tb01122.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

AbstractThe case of a woman with autonomous aldosteronism, hypertension, and malignant ovarian tumour is reported. Hormone studies revealed high plasma aldosterone levels, and low plasma renin concentration. Following surgical removal of a malignant sex cord stromal tumour, the hyperaldosteronism regressed, and the hypertension improved. Subsequently the tumour recurred, as did hyperaldosteronism.

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1986.tb01123.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

AbstractA 37 year old female with rheumatoid arthritis developed clinical and biochemical evidence of hepatitis after receiving 80 mg of sodium aurothiomalate. Inadvertent rechallenge with sodium aurothiomalate led to recurrence of the biochemical abnormalities and a profound neutropenia and eosinophilia.

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1986.tb01124.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY