摘要:

Abstract:Use of ipratropium bromide in patients with severe airways obstruction. R. J. Pierce, P. W. Holmes and A, H. Campbell,Aust. N.Z. J. Med.,1982, 12, pp. 38–43.In ten adult patients with severe, partially reversible airflow obstruction due to asthma, with or without co‐existent chronic bronchitis, the acute bronchodilator responses of ipratropium bromide (40 fig) and terbutaline (500 fig) from metered‐dose inhalers, atropine methonitrate (2 mg) as a wet aerosol and placebo were compared in a double blind trial. Also the combination of ipratropium bromide and terbutaline aerosols was compared with both ipratropium and terbutaline alone in short‐term and long‐term studies.In the short‐term study, all the drugs produced significant bronchodilatation compared with placebo. The responses to ipratropium bromide and terbutaline alone were not significantly different. The combination of ipratropium bromide with terbutaline did not produce significantly greater changes in the FEVUSGaw or static lung volume than terbutaline alone. Atropine methonitrate however, produced significantly greater changes of the airway conductance (SGaw) and static lung volumes (TLC and RV) but not FEV, when compared to ipratropium bromide.When administered over randomised periods of one month each there were no significant differences between the combination of ipratropium bromide and terbutaline and each drug alone in daily airflometer recordings, daily symptom scores or fort‐ nightly spirometry and clinical assessment.It is concluded that ipratropium bromide, in the conventional dose of 40 pgm by metered‐ dose inhaler produces safe, effective broncho‐dilatation. Its effect, however, did not significantly augment that of the fl adrenergic stimulant, terbutaline and was less than that of atropine methonitrate 2

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1982.tb02423.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

Abstract:Residual pancreatic function in insulin dependent diabetics. C. Glatthaar, D. W. Beaven, R. A. Donald, J. R. Smith and E. A. Espiner,Aust. N.Z. J. Med.,1982, 12, pp. 43–47.The relative contributions of alpha and residual beta cell function and the presence of insulin binding antibodies to indices of glucose control have been assessed in a group of 44 patients with insulin dependent disease of variable duration. Residual beta cell secretion was detected in 18 patients (40%) but no patient receiving insulin for more than five years showed evidence of residual function. Indices of glucose control were significantly better (p<0 001) in patients demonstrating residual secretion. In contrast, no relation was found between glucose control and either fasting or post prandial plasma glucagon concentrations. Insulin binding antibodies were detected in all but two patients but did not correlate with either daily insulin dose or glucose control. These results are consistent with the view that residual beta cell function contributes to improved glucose control in the early years of insulin dependency but alpha cell function and insulin antibodies do no

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1982.tb02424.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

Abstract:Familial optic atrophy with diabetes mellitus. J. D. Wilson, R. W. Simpson, M. L. Wahlqvist, I. Favilla and B. D. Tait,Aust. N.Z. J. Med.,1982, 12, pp. 48–51.A family of eleven members is described in which three siblings have optic atrophy, two of whom are insulin dependent diabetics, while the other has glucose intolerance. No evidence was found to suggest an autoimmune basis for this syndrome. There was no direct evidence that genetic susceptibility to this syndrome is HLA linked. The presence of DR2 and the absence of DR3 and DR4 in the affected individuals suggests that the diabetes mellitus in this syndrome is distinct from the common form of insulin‐dependent diabetes melli

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1982.tb02425.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

Abstract:Surgical division of right and left free wall accessory atrioventricular electrical connections in a child with incessant supraventricular tachycardia. D. Richards, A. Denniss, P. Russell, D. Johnson, N. Buchanan, C. Whight, A. Chong and J. Uther,Aust. N.Z. J. Med.,1982,12, pp. 52–55.A child with Wolff‐Parkinson‐White syndrome developed incessant supraventricular tachycardia refractory to medical therapy and countershocks. Supraventricular tachycardias incorporating both right and left free wall accessory atrioventricular electrical connections were demonstrated. The more frequent, broad complex tachycardia utilised both the accessory connections and was independent of the atrioventricular node. The less frequent, narrow complex tachycardia utilised the atrioventricular node for anterograde conduction and the left sided accessory connection for retrograde conduction. Surgical division of the accessory connections restored normal sinus rhythm and eliminated supraventricular tachyc

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1982.tb02426.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

Abstract:Pseudoaneurysm of the left ventricle diagnosed by two dimensional echocardiography. L. Lee, J. Healey and J. D. Woolridge,Aust. N.Z. J. Med.,1982, 12, pp. 56–59.A patient with pseudoaneurysm of the left ventricle, a rare complication of transmural myocardial infarction, is reported. The differentiation of the pseudoaneurysm from true aneurysm of the left ventricle was made by two‐dimensional echocardiography, and the practical importance of making this distinction is discus

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1982.tb02427.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

Abstract:Toxic‐shock syndrome in a male complicated by oliguric acute renal failure. R. F. Raper and L. S. Ibels,Aust. N.Z. J. Med.,1982, 12, pp. 60–62.A case of the toxic‐shock syndrome occurring in a male is presented. The major features included severe, oliguric renal failure, acute respiratory failure, neurological complications and complete recovery. The clinico‐patho‐logical features are discussed with emphasis on the relationship of this syndrome to staphylococcal infections without identifiable blood borne dissemination. Although previous reports have largely concentrated on the association of the toxic‐shock syndrome with tampon use in menstruating women the possible occurrence of this syndrome in any patient with staphylococcal infection is

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1982.tb02428.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

Abstract:Hyperkalemia in a diabetic due to renal tubular unresponsiveness to aldosterone. K. M. Bannister and L. J. Barratt,Aust. N.Z. J. Med.,1982, 12, pp. 63–66.Studies of a patient with diabetic nephropathy and chronic hyperkalemia are reported. It is proposed that the underlying functional abnormality was renal tubular unresponsiveness to aldosteron

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1982.tb02429.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

Abstract:Spontaneous pneumocephalus following elective thoracotomy. A. C. Reid, K. G. Davidson, K. W. Grossart and W. F. Durward,Aust. N.Z. J. Med.,1982, 12, pp. 67–69.One month following a right upper lobectomy for bronchial carcinoma, a 50‐year‐old man developed headaches, confusion and a right hemiparesis. Radiographs revealed intraventricular air. This was thought to have originated from air being forced through a dural tear sustained at the time of operation. Both the intraventricular air and the accompanying symptoms and signs subsequently res

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1982.tb02430.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

Abstract:Benign pleural mesothelioma with tumour‐induced hypoglycaemia. K. R. Burgess, J. Rutland, G. E. Marlin, P. J. Maloney and D. C. Perry,Aust. N.Z. J. Med.,1982, 12, pp. 70–72.A patient with a rare tumour, benign pleural mesothelioma, associated with hypoglycaemia is reported. He presented with a neuropsychiatric disturbance and was successfully treated by surgical removal of the tumour. Glucose tolerance tests and serum insulin levels suggested secretion of an insulin‐like substance by the tumour. Glucose consumption by the tumour may have contributed to the hypoglyc

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1982.tb02431.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

Abstract:Absence of PAS‐positive macrophages In hepatic and lymph node granulomata in Whipple's disease. P. J. Torzillo, L. Bignold and G. A. Khan,Aust. N.Z. J. Med.,1982, 12, pp. 73–75.A patient with Whipple's disease presented with hepatic and lymph node granulomata which contained no PAS‐positive macrophages but which disappeared after penicillin treatment. The absence of PAS‐positive staining in the macrophages of hepatic granulomata in Whipple's disease has not previously been reported but does not negate the di

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1982.tb02432.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY