摘要:

Abstract:The glucagonoma syndrome: an unusual skin rash associated with diarrhoea and diabetes. R. D. Johnson, R. G. Larkins. J. H. Iser. I. C. Roberts‐Thomson and G. A. Kune.Aust. N.Z. J. Med., 1981, 11, pp. 59–63.The glucagonoma syndrome, due to a glucagon secreting islet cell neoplasm of the pancreas, is a rare condition which has been characterized only in recent years. Although the syndrome includes an unusual skin rash (necrolytic migratory erythema), diabetes, anaemia and weight loss, its rarity usually leads to delay in recognition and diagnosis. Here we report another patient with this syndrome who appears to have been cured by radical surgery after a four year delay in diagn

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1981.tb03738.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

Abstract:Cholestasis as a paraneoplastic manifestation of carcinoma of the kidney. A. W. Jakobovits, F. B. Crimmins, S. Sherlock, S. Erlrnger and J. Rambaud.Aust. N.Z. J. Med., 1981, 11, pp. 64–67Two cases of hepatic paraneoplastic manifestations of carcinoma of the kidney are presented. In one, hepatosplenomegaly and abnormal liver function tests resolved following removal of the tumour. In the other, pruritus as a symptom of cholestasis was the presenting feature. Post‐operatively a full blown cholestatic syndrome developed. Although their clinical presentations differed they may represent a spectrum of the same dis

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1981.tb03739.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

Abstract:Acute pandysautonomia due to mixed connective tissue disease. J. Edelman, S. S. Gubbay and P. J. Zilko,Aust. N.Z. J. Med., 1981.11, pp. 68–70.A patient with acute pandysautonomia with partial recovery is described. The associated finding of serological and clinical features of mixed connective tissue disease suggests the strong possibility of an auto‐immune pathogen

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1981.tb03740.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

Abstract:Hypertrophic osteoarthropathy complicating primary bone marrow iymphoma—association with invasive phycomycosis and aspergillus infections. M. M. McNeil, R. E. Sage and B. M. Dale,Aust. N.Z. J. Med., 1981, 11, pp. 71–75.The development of hypertrophic osteoarthropathy in patients with ieukaemia or lymphoma presents important diagnostic and therapeutic implications. Patients with these disorders are also predisposed to the development of invasive phycomycosis and aspergillus infections. We report a case of primary bone marrow lymphoma complicated by hypertrophic osteoarthropathy. At postmortem examination there was evidence of disseminated phycomycosis and aspergillus infections. We believe this relationship has not previously been repo

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1981.tb03741.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1981.tb03742.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

Abstract:Aortic and mitral valve replacement in a patient with severe haemophilia A. P. D. Meagher, K. A. Rickard, J. G. Richards and D. K. Baird,Aust. N.Z. J. Med., 1981, 11, pp. 7679.A forty‐nine year old man with severe Haemophilia A developed left ventricular failure as a complication of valvular heart disease. On November 26th, 1979, open heart surgery was performed and both the aortic and mitral valves were replaced with porcine heterograftsReplacement therapy in the form of Factor Vlll concentrates maintained the Factor Vlll coagulant level at 100% until ten days post‐operatively and a total dose of 116,600 units were givenThe patient described is the first haemophiliac to undergo open heart surgery in Australia and the first reported case in the world to have had a successful double valve graftWith the current availability of factor Vlll concentrates, elective surgical procedures are being performed more frequently. Such procedures require careful pre‐operative planning and post‐operative monitoring of replacement therapy to ensure satisfactory haemostasis. Although haemostatic defects may occur after open heart surgery, this case report illustrates that the haemostatic problems of open heart surgery and haemophilia can be prevented by pre‐operative planning and meticulous postoperative monitoring of replaceme

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1981.tb03743.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

Abstract:Captopril‐induced agranulocytosis in systemic sclerosis. M. A. Watson, N. J. Radford, B. P. McGrath, G. W. Swinton and J. W. M. Agar,Aust. N.Z. J. Med., 1981, 11, pp. 79–81.A 25 year old woman with systemic sclerosis developed severe but reversible agranulocytosis seven weeks after commencing treatment with Captopril for severe hypertension and renal impairmentThe evidence suggests that the agranulocytosis was caused by Capto

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1981.tb03744.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

Abstract:An acute attack of variegate porphyria complicated by severe autonomic neuropathy. P. M. Stewart and W. J. Hensley,Aust. N.Z. J. Med., 1981, 11, pp. 82–83.A patient with familial variegate porphyria is described. She was admitted in an acute attack and developed severe dysautonomia manifested clinically by postural hypotension, tachycardia and constipation with severe abdominal pain. Whilst formal testing of autonomic function demonstrated the presence of marked abnormalities, peripheral nerve conduction studies were norm

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1981.tb03745.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

Abstract:Lipid absorption and intestinal lipoprotein formation. P. H. R. Green and J. W. Riley,Aust. N.Z. J. Med., 1981, 11, pp. 84–90.Lipid absorption is a complex process which involves coordinated gastric, intestinal, biliary and pancreatic function. Emulsification of dietry lipid occurs in the stomach and upper intestine where a series of enzymic events also occur. Phospholipids are digested by phospholipases. Colipase anchors lipase to the emulsion surface overcoming the interfering effect of bile salts. The products of lipolysis, monoglycerides and fatty acids, are removed from the emulsion surface by bile salts in the form of mixed micelles which transport lipid digestive products across the unstirred water layer to the epithelial cellWithin the intestinal epithelial cell a series of synthetic events occur resulting in the formation of chylomicrons and very low density lipoprotein (VLDL). Chylomicrons consists of an oily core of triglyceride surrounded by a membrane of phospholipids, free cholesterol and apoproteins which maintain the solubility of the particle in plasma. Chylomicrons from both experimental animals and man have specific apoproteins associated with them. These proteins include apoA‐I, the major protein of plasma high density lipoproteins. During chylomicron metabolism, apoA‐I and phospholipid from the chylomicron surface contribute to plasma high density lipoproteins. Other chylomicron apoproteins include apoB and apoA‐IV, which are synthesized in the intestine, and apoC and apoE which are absorbed onto the chylomicron surface from other lipoproteinsThe intestine also synthesizes, very low density sized particles (VLDL) while fasting and during lipid absorption. There is evidence that the intestine also synthesizes high density lipoproteinsThe intestine has recently been recognized as a major site of synthesis of plasma lipoproteins and apoproteins, especially apoA‐I for plasma high density li

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1981.tb03746.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1981.tb03747.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY