ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1988.tb00140.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1988.tb00141.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

AbstractThe value of digital subtraction angiography (DSA), in assessing aortocoronary bypass graft patency, was evaluated by studying 22 consecutive patients with 54 aortocoronary saphenous vein bypass grafts, who had postoperative angina pectoris. Each patient underwent selective graft angiography and non‐gated DSA. The DSA consisted of a run of 15 to 20 frames, taken at 2.3 frames per second during injection of diluted contrast in the ascending aorta, performed after a test exposure was made.Thirty‐two of the 54 grafts (59%) were patent. Thirty of the 32 grafts were seen to be patent by both selective graft angiography and DSA. In addition, a further two grafts were found to be patent on DSA, but were not able to be selectively catheterised and were not seen on the conventional aortogram. Selective graft angiography revealed four tight proximal graft stenoses, of which one only was seen on DSA; and poor distal run‐off in five grafts, two of which showed up as late filling grafts on DSA.In summary, the accuracy of intra‐arterial DSA in assessment of bypass graft patency was excellent. All grafts seen to be patent on selective graft angiography were also seen by DSA alone and in addition two grafts which could not be selectively catheterised were found to be patent. However, in patients with postoperative chest pain, selective graft angiography is probably required as non‐gated intra‐arterial DSA does not provide sufficient information to assess graft stenoses, distal flow and the native coron

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1988.tb00142.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1988.tb00143.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

AbstractSeveral studies have suggested that delays in the latency of the P300 ERP component are highly sensitive and specific to dementia and that ERP measurements may become a useful clinical tool in aiding diagnosis. This study examines the sensitivity of P300 measurements to dementia and addresses several methodological issues that limit previous research. Twenty‐four patients with dementia diagnosed according to ICD‐10 criteria were compared with 100 normal controls, 31 of whom were older than 60. An auditory oddball paradigm was employed to elicit the P300. Mean P300 latency did not differ significantly between the two groups. When individual subjects were examined only 13% of patients with dementia fell outside the two standard error band of the regression of P300 latency on age derived from controls. Thus, this study has not demonstrated clinically useful abnormalities of the P300 component in demen

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1988.tb00144.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

AbstractThe incidence of surgery for gastric cancer in Singapore increased during the period 1951 to 1980 (males from 3.5 to 8.7 per 100 000 per year: females from 0.5 to 4.2 per 100 000 per year). This increase occurred mainly during the first decade of the study and was confined to persons aged 55 and above. Chinese had the highest incidence, followed by Indians and then Malays. These racial differences remained unchanged over the period of study.

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1988.tb00145.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

AbstractAn association betweenHerpes simplexVirus 1 (HSV‐1) and duodenal ulcer disease has been suggested. Duodenal ulcers, like HSV‐1 lesions, exhibit periodicity in recurrence. Several of the presently available anti‐ulcer agents may have an antiviral action. Antibody titres in some studies have shown selective increases to HSV‐1 in duodenal ulcer patients. The aim of this study was to determine whether a real association exists between HSV‐1 and endoscopically proven duodenal ulcer or duodenal erosive disease. In a prospective study, 27 patients with either duodenal ulcer (16) or duodenal erosions (11) were studied in order to attempt isolation of HSV‐1. Acute and convalescent sera were also taken and examined by an enzyme linked‐immunoabsorbent assay system for antibody titres to HSV‐1. Duodenal biopsies from a further 26 patients with duodenal ulcer or erosive disease were also examined retrospectively for HSV‐1 by the immunoperoxidase technique.In no case of either duodenal ulcer or duodenal erosive disease was HSV‐1 isolated by any of the above methods, nor was a relationship demonstrated by acute or convalescent HSV‐1 antibody titres. Hence, this study does not support an association between HSV‐1 and duodenal u

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1988.tb00146.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

AbstractIn a routine clinic of patients taking regular oral anticoagulant therapy (warfarin,n= 140) 14% were found to have elevated levels (>4 SD above normal) of anticardiolipin antibody (ACA) assessed by a well standardised enzyme linked immunosorbent assay (ELISA).There was a higher incidence of raised ACA in patients being treated for thrombotic episodes (9/47 = 19%) than in cases with heart valve replacements (8/75 = 11%). Furthermore, the highest ACA titres were in younger patients with thromboses scheduled for short‐term anticoagulant treatment. Borderline DNA binding studies, together with some positive ANA results, suggested autoimmune etiology in the minority of these cases. Lupus anticoagulant was strongly detectable in only one such patient.The ACA were predominantly IgG (14/17) and did not appear to compromise the conditions of patients while on anticoagulant therapy. Raised ACA may be a highly significant marker for an acquired prothrombotic stat

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1988.tb00147.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1988.tb00148.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

AbstractAdult polycystic kidney disease (APKD) is one of the most common inherited diseases in man. A diagnosis based on the demonstration of renal cysts with ultrasonography or computerised tomography may be inconclusive in early adulthood, the crucial years before child‐bearing is complete. Here we describe the improved diagnostic probability that is possible using genetic linkage studies.A 24‐year‐old woman, whose father and younger sister were affected by APKD, was demonstrated to have a single cyst in each kidney. These findings were insufficient for a diagnosis of APKD1and for this reason genetic linkage studies were undertaken. DNA was extracted from peripheral blood leukocytes from the presenting individual, and her immediate and extended family; the DNA was cut with the restriction enzyme PvuII, electrophoresed in a 0.7% agarose gel and blotted onto nitrocellulose before probing with a32P‐labelled 4 kb fragment. This contained DNA from the hypervariable region (3′ hypervariable region, 3′HVR) that is linked to the gene for APKD on the short arm of chromosome 16 and has been used in other family studies by Reederset al.2We correlated the findings on Southern blotting with ultrasound evidence of APKD and found that the disease segregated with a 7.0 kb fragment in the presenting individual's father and sister. She was shown to have inherited this allele also; the use of this technique thus increased the probability of her having APKD from 50

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1988.tb00149.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY