摘要:

Summary:Kidney biopsies from ten children with recurrent macroscopic haematuria, showed mesangial deposition of IgG, IgA and complement. Eight of these ten biopsies also showed deposition of properdin, a basic euglobulin intimately involved in the alternate pathway of complement activation. Serum haemolytic complement activity was normal in the eight patients tested. Incubation of the serum at 4 °C for 24 hours did not result in any change in complement activity.These data suggest that the mesangial inflammatory process in these patients may be mediated in part by the alternate pathway of complement activation and that the mechanism is activated locally

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1975.tb04566.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

Summary:Cold agglutinin formation in patients undergoing haemodialysis. A possible relationship to dialyser re‐use.Cold agglutinins with anti‐N characteristics were shown to develop in as short a time as four months in patients on home dialysis. It appeared that the development of such antibodies is related to dialyser re‐use. Those who were treated without re‐using their dialyser did not develop these antibodies.Anti‐N may cause early graft failure associated with agglutination in a cold allograft. Moreover, if these antibodies develop in patients on dialysis there may be problems with extracorporeal dialysis and blood tr

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1975.tb04567.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

Summary:The effect of impairment of renal function and dialysis on the serum and urine levels of clindamycin.A single 150 mg oral dose of clindamycin was given to three healthy volunteers and 13 patients with varying degrees of renal functional impairment. The mean peak serum levels in the two groups were 2.55±0.92 μg/ml and 3.39±0.68 μg/ml respectively. In all patients the levels greatly exceeded the minimum inhibitory concentration for sensitive pathogens. The serum half‐life was extremely variable in patients with renal failure and bore no relationship to the glomerular filtration rate. In the normal subjects 11.9% of the administered dose was excreted in the urine but in severe renal failure less than 1% of the bioactivity was detected in the urine in 24 hours. The drug was not removed by haemodialysis.In patients with mild to moderate impairment of renal function no dosage adjustment of clindamycin is necessary. However, in those with severe renal failure some modification to dosage would be prudent and this should be monitored by measuring serum levels of the antib

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1975.tb04568.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

Summary:A study of serum and myocardial digoxin concentrations in man during cardiac arrest.In 22 digitalized (of a total of 39) patients studied at random by radioimmunoassay during cardiac arrest, the mean serum digoxin concentration was 2·6 (±1·86, range 0·6–8·2) ng/ml, significantly higher (P<0·001) than the “eudigitalized” concentration (1·3±0·52, range 0·5–2·3 ng/ml) determined under carefully standardized conditions in a non‐toxic population. Half of the arrest patients had serum digoxin levels in the toxic range (2·4 ng/ml or above), mainly due to significant renal failure (mean serum creatinine concentration 2·9±2·66 v. 1·0±26 mg/dl for non‐toxic subjects,P<0·001), partly due to a higher mean daily digoxin dose (0·40 v. 0·31 mg/day,P<0·05) and frequently associated with potent diuretic therapy (73 v. 54%). A smaller fraction of digitalized patients survived, both short‐(27%) and long‐term (14%), than did non‐digitalized subjects (35% and 26%, respectively). The mean myocardial digoxin concentration was 150 (·63±3, range 52–252) ng/g with an average myocardial/serum ratio of 62·5 (range 38–91). There were significant positive correlations between the serum digoxin and left‐ventricular myocardial digoxin concentration (r= 0·8107,P<0·01) or serum creatinine concentration (r= 0·4637P<0·001).The research program was supported by a grant from the Nation

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1975.tb04569.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

Summary:Type V hyperlipoproteinaemia re‐visited: Findings in a Sydney population.The clinical and biochemical features of eleven patients with Type V hyperlipoproteinaemia have been reviewed. All patients were male, and there was a high incidence in the group of obesity, vascular disease, acute abdominal pain, gout, diabetes mellitus and alcoholism. Plasma cholesterol concentrations ranged from 212 to 1512 mg/100 ml and triglycerides from 708 to 7670 mg/100 ml. Lipaemia was associated with significant hyponatraemia, and also interfered with the determination of plasma glucose and serum amylase. Chylomicronaemia and hyperprebetalipoproteinaemia were accompanied by reduction in the pools of beta and alpha lipoproteins. All lipoprotein classes were relatively depleted of cholesterol compared to triglyceride.There was a variable pattern of treatment response. In some patients alcohol withdrawal produced a rapid improvement in plasma lipids. In diabetes mellitus there were two types of response: a rapid one in chronic insulin deficiency, and secondly, a more gradual one in mild diabetes associated with hyperinsulinaemia. In other patients there was a rapid response to carbohydratecalorie restriction but the respective contributions of each of the steps remained unclea

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1975.tb04570.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

Summary:An evaluation of a new ECG monitor which detects and classifies ventricular extrasystoles.A device is described which is highly efficient in detecting and classifying ventricular ectopic beats. This instrument may have a significant role in patient monitoring. The system is based on analysis of a 5 electrode orthogonal system with comparison of QRS wave forms with a stored normal wave form. The design was based on a test tape derived from 26 patients and evaluated further on long recordings of 16 other patients. Results indicate that the device is highly reliable in QRS detection and in detection of ventricular ectopic beats. The problem of artefacts due mainly to patient movement is held within reasonable limits.

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1975.tb04571.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

Summary:The effect of multiphasic biochemical screening on the diagnosis of primary hyperparathyroidismExperience of primary hyperparathyroidism (PHPT) at the Royal Brisbane Hospital was reviewed to determine the effect of multiphasic biochemical screening, introduced during 1970, on the rate of diagnosis of this disease. In the period 1959–1970, there were 28 proved cases and, in the period 1971–1974, 41 cases, an increase from 2·5 to 11·7 cases per annum. The main factor contributing to this increase was the inclusion of plasma calcium in the multiphasic screening programme, together with correction of the plasma calcium for the total protein concentration in the same blood s

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1975.tb04572.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

Summary:The pituitary‐testicular response to luteinising hormone releasing hormone administration to normal men.The response of the pituitary and testis in normal men to the injection of LH‐RH has been studied using single intravenous doses of either 25 μg or 100 μg.Serum LH levels rose with both doses but significant elevation of plasma testosterone was evident only following 100 μg of LH‐RH. Though testosterone levels were elevated within 60 minutes, peak responses occurred from 4–12 hours post‐injection. The rise in serum FSH levels was small or absent at 25 μg but was clearly present following 100 μg LH‐RH, in general rising more slowly than LH levels but persisting for

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1975.tb04573.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

Summary:The effect of carbenoxolone sodium on the plasma 11 hydroxycorticoid levels in chronic gastric ulceration.The mineralocorticoid effects of carbenoxolone sodium are well established and seem related to the ulcer healing of the drug. In the present study the plasma 11 hydroxycorticoid responses were assessed in 12 patients undergoing treatment with carbenoxolone for chronic gastric ulceration. After treatment with carbenoxolone for one month the plasma 11 hydroxycorticoid levels rose significantly, suppression by dexamethasone was less marked and the normal diurnal periodicity was abolished. Carbenoxolone therapy influences the results of tests designed to assess the function of the pituitary‐adrenal axis and may lead to sub‐clinical adrenocortical hyperfunct

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1975.tb04574.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

Summary:The frequency of occurrence of hepatitis B antigen (HBAg) and certain tissue auto‐antibodies [antinuclear antibody (ANA), smooth muscle antibody (SMA) and mitochondrial antibody (MIA)] were studied with the microtiter complement fixation and immunofluorescence techniques respectively in a group of patients suffering from chronic liver diseases. These were chronic hepatitis (30), cirrhosis of the liver (66) and hepatocellular carcinoma, mostly with underlying cirrhosis (100). A group of closely matched hospital in‐patients served as controls. HBAg was found in high frequency in the patients with liver disease (60% in chronic hepatitis, 36·4% in cirrhosis and 49% in hepatocellular carcinoma) whereas tissue auto‐antibodies were found in lower frequencies (16·7%, 10·6% and 13% in the three groups respectively). However, in both the frequency was significantly higher than that in the controls (9·2% for HBAg and 0·8% for auto‐antibodies). There was a negative correlation between HBAg and tissue auto‐antibodies in the group of patients with liver disease when taken as a whole (·2= 14·3,P<0·001). These results suggest a possible aetiological role played by hepatitis virus B in hepatocellular carcinoma through chronic hepatitis and cirrhosis in Hong Kong while the mutual exclusion between HBAg and auto‐antibodies supports the hypothesis of heterogeneity in the aetiology of chronic liver diseases. The patients with auto‐antibodies may belong to the auto‐immune category but no definite conclusion can be reached until the role played by hepatitis virus A in chronic liver diseases is clarified when more reliable techniques for its ident

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1975.tb04575.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY