ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1982.tb02440.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1982.tb02441.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1982.tb02442.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

Abstract:Inflammatory bowel disease in Auckland, New Zealand. R. J. Eason, S. P. Lee and C. Tasman–Jones,Aust. N.Z. J. Med.,1982, 12, pp. 125–131.Four–hundred–and–fifty–six patients with ulcerative colitis (UC) and 137 patients with Crohn's disease (CD) attended public hospitals within Auckland between 1969 and 1978. Polynesians comprised 15% of the population at risk but accounted for only 0–4% of UC cases and no CD cases. Annual incidence rates were 5–4/100,000 Caucasians for UC and 1–75 for CD. CD was significantly less common in Auckland than in European and North American centres. For patients presenting for the first time between 1969 and 1978, the cumulative probability of surviving 10 years was 93–9% for UC and 89–1% for CD. An excess of observed over expected mortality was limited to the first year of observation in UC and did not occur in CD. Clinical features and local complications of UC and CD have been correlated with the anatomic location of disease. In this first clinical study of inflammatory bowel disease in New Zealand, 61% of CD and 23% of UC patients required at least o

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1982.tb02443.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

Abstract:Simple endoscopic injection sclerotherapy of oesophageal varices. O. D. Harris, J. D. Dickey and P. M. Stephenson,Aust. N.Z. J. Med.,1982, 12, pp. 131–135.A routine upper gastrointestinal fiberoscope (Olympus GIFK) was used for endoscopic sclerotherapy of varices in 38 patients sedated with I.V. diazepam. It was effective in preventing rebleeding in 30 patients, and greatly reducing the size and number of varices in 31 of the patients. This endoscope needs no additional cuff or sheath for this therapy. It is easier to use and safer than the rigid oesophago–scope. Sodium tetradecyl sulphate is as effective as ethanolamine oleate as a sclerosant and causes no chest pain. Four patients developed a fibrotic lower oesophageal stricture. One patient developed an intramural haematoma that was followed by bacteraemia and de

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1982.tb02444.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

Abstract:Primary gastrointestinal tract lymphoma. K. S. Crowley, G. Don, G. E. Gibson, C. A. Juttner and JR. Miliauskas,Aust. N.Z. J. Med.,1982, 12, pp. 135–142.A retrospective study of 28 patients with primary gastrointestinal tract lymphoma is presented. There were 27 cases of non–Hodgkin's lymphoma and one case of Hodgkin's disease. The patients with non–Hodgkin's lymphoma of the gastrointestinal tract represented 10% of all non–Hodgkin's lymphoma cases seen at the Royal Adelaide Hospital/Institute of Medical and Veterinary Science complex over the six year survey period, 1972–1977.Of the patients with non–Hodgkin's lymphoma, 26 cases were diffuse type, and one case was nodular type. There was a M/F sex preponderance of 2–811, and 70% of cases were aged between 40 and 69 years. The commonest site was the stomach (19 cases), followed by small intestine (7 cases), and one case involved large intestine. At initial presentation, the disease was confined to the affected viscus (Stage IE) in seven patients (25%), and in 12 patients (43%) the disease involved viscus and regional lymph nodes (Stage HE). The one patient with Hodgkin's disease had involvement of the large intestine, abdominal lymph nodes and bone marrow (Stage IV).This study was retrospective, and a management protocol was not employed. However, of the seven patients presenting with Stage IE disease, six cases had diffuse poorly differentiated lymphocytic lymphoma. Five of these patients were treated by surgical resection alone, and were in complete remission at follow–up of 66 to 103 months.In order to compare realistically the survival of different groups of patients with primary gastrointestinal lymphoma, we consider that a prospective multicentre clinical trial with comprehensive staging procedures, uniform histological classification and accepted management protoc

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1982.tb02445.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

Abstract:Treatment of acute myeloid leukaemia in children. C. M. Paton, H. Ekert, K. D. Waters, R. N. Matthews and I. R. G. Toogood,Aust. N.Z. J. Med.,1982, 12, pp. 143–146.Complete remission was achieved in 11 of 22 children with acute myeloid leukaemia using at least two courses of a 24 hour infusion of cytosine arabinoside (Ara–C) 10 mg/kg, followed by push injections of daunorubicin (DNR) 45 mglm2, and adriamycin (ADR) 45 mglm2. Consolidation therapy consisted of three courses of Ara–C and 6–thioguanine (Tg) and one course of cyclophosphamide (CPA) and ADR. Central nervous system prophylaxis with intrathecal Ara–C was given in all patients and cranial irradiation in five. Maintenance therapy consisted of 5 day courses of Ara–C and Tg given 4 weekly with immunotherapy (BCG vaccine and subcutaneous leukaemic cells) between courses.Median length of first complete remission was 99+ weeks, and median survival of all patients was 44 weeks. Median survival of remitters was 195+ weeks and non–remitters, 28 weeks. Two patients developed central nervous system disease, one at presentation and the other 46 weeks from presentation. Five patients have ceased therapy and remain in remission from 32 to 142 weeks after ceas

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1982.tb02446.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

Abstract:Significant factors in the optimal management of advanced stage germ cell carcinoma. J. A. Levi, R. S. Aroney and D. N. Dalley,Aust. N.Z. J. Med.,1982, 12, pp. 147–152.Twenty–two patients with advanced stage germ cell carcinomas received a combination chemotherapy regimen of cis–platinum, vinblastine, bleomycin and actinomycin D. There were 16 (73%) complete remissions, (five documented at surgery), one patient (5%) whose residual disease was completely resected and five (22%) partial remissions. The only adverse significant pretreatment factors were extent or bulk of initial disease and poor performance status. Prior radiotherapy or chemotherapy did not influence the potential to achieve complete remission, but was associated with increased haematological toxicity. Toxicities were common and there were three treatment related deaths, one from septicaemia and two from pulmonary fibrosis, emphasising the need for expertise and optimal supportive care when administering this complicated regimen. There was a significant survival advantage for the patients achieving disease–free status compared to partial responders (p = 002). Only one relapse has occurred among the former group with 82% alive and disease–free with follow–up of 27–50 months, indicating the majority of these patients may be cured. Management of advanced stage germ cell carcinoma can now be considered highly successful although further studies are needed to determine optimal treatment for patients with bulky disease and the role, if any, of mainte

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1982.tb02447.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

Abstract:Evaluation of a diabetes education programme. K. L. Webb, A. J. Dobson, H. E. Tupling, G. W. Harris, D. L. O'Connell, J. Atkinson, M. J. Sulway and S. R. Leeder,Aust. N.Z. J. Med.,1982, 12, pp. 153–160.An education programme was evaluated for 140 insulin–dependent diabetics and their family members from 1978 to 1980. Dietary, biochemical and other assessments were made before and 6 months after the programme.As a group, the diabetics were initially in good metabolic control and this was maintained, or improved, over the study period.The programme recommendedadiet in which complex carbohydrate constituted at least 45% of energy intake and fat was limited to 30%. The diabetics and their family members significantly increased their consumption of complex carbohydrate and decreased fat intake. On this regi

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1982.tb02448.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY

摘要:

Abstract:Serum myoglobin, creatine kinase and creatine kinase–MB as mutually supportive indices of myocardial infarction and infarct size*. R. N. Johnson, W. F. Lubbe, C. J. Mercer, N. L. Sammel and R. M. Norris,Aust. N.Z. J. Med.,1982, 12, pp. 160–165.A comparison was made between the appearance of serum myoglobin and creatine kinase in 22 patients with acute myocardial infarction who were admitted to a coronary–care unit within four hours of onset of chest pain. The MB isoenzyme of creatine kinase was measured in 12 patients. The more rapid appearance and disappearance of myoglobin relative to creatine kinase and creatine kinase–MB was confirmed, as was the correspondence between their respective peak values. A significant correlation was also obtained between the area under the myoglobin time–course and the respective peak levels. Whereas creatine kinase activity declined exponentially from a single peak, myoglobin appeared in multiple episodes inadequately represented by a single peak value and having no clear clinical correlation. The role of myoglobin as a diagnostic aid in myocardial infarction is probably limited to its ability to support creatine kinase and creatine kinase–MB as indices of i

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1982.tb02449.x

出版商:Blackwell Publishing Ltd    

年代:1982

数据来源: WILEY