ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1978.tb04516.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1978.tb04517.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

Summary:Testicular damage due to cytotoxic drugs and recovery after cessation of therapy.Testicular function was assessed in 32 patients who received standard chemotherapy regimens for disseminated lymphomas. Thirty‐one had evidence of germ cell damage, as assessed by the finding of azoospermia and/or high plasma levels of follicle‐stimulating hormone (FSH). In addition, five patients had persistently low plasma testosterone levels associated in three with elevated plasma luteinising hormone (LH) levels.Reproductive function did not recover in any patient while chemotherapy continued. Cessation of therapy was possible in 16 patients with prolonged remissions of disease. Among these, recovery of germinal epithelium differed greatly between the cyclophosphamide / vincristine / prednisone treated group and the mustine I procarbazine / vincristine/prednisone treated group. Seventy per cent of the former patients had evidence of recovery after 34 months of follow‐up while only one (17%) of the latter had begun to recover at 52 months post‐therapy. Serial measurement of plasma FSH levels proved useful in predicting likely recovery of spermato

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1978.tb04518.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

Summary:A quantitative review of the performance of implanted cardiac pacemakers, Medtronic Model No. 5944.One of the service functions of the Sir Charles Gairdner Hospital Department of Biophysics since 1972 has been the routine performance testing of pacemakers implanted by the Hospital's Cardiologists. This service was set up to measure pacemaker pulse parameters with a view to detecting battery depletion. It was also found to be of great help in showing lead insulation deterioration, intermittent capture and movement of the catheter tip within the right ventricle, information that is frequently of help to the Cardiologists in planning acute or elective pacemaker replacement.

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1978.tb04519.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

Summary:Serum pyridoxal concentrations in patients with diabetic neuropathy.Serum pyridoxal (vitamin B6) concentrations were measured in 50 patients with significant diabetic neuropathy. There were 24 males and 26 females with a mean age of 58·2 years and a mean duration of diabetes of 9·8 years. The level of pyridoxal was significantly lower in these patients when compared with randomly selected diabetic patients matched for age and sex without clinical evidence of neuropathy. There was no significant difference in the duration of the diabetes between the two groups. The results indicate an association between pyridoxal deficiency and neuropathy in diabetic patient

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1978.tb04520.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

Summary:Treatment of amenorrhoea, galactorrhoea and hypogonadism with bromocriptine.The effect of bromocriptine administration was studied in 34 patients, whose presenting symptoms included amenorrhoea, galactorrhoea, infertility, dyspareunia, delayed puberty, and impotence. Two patients were found to have raised plasma prolactin values during investigation for acromegaly. With the exception of three individuals all patients had hyperprolactinaemia. Pituitary fossa enlargement or asymmetry was reported in 16 patients and one patient had primary hypothyroidism.Virtually all patients complained of side effects when first starting bromocriptine but only two patients were unable to tolerate prolonged therapy with doses which ranged from 5–40 mg daily. A single oral dose of 2·5 mg resulted in a greater than 50% reduction in plasma prolactin within five hours in 22 of 26 patients. Over the course of one month, five patients with significant pituitary fossa enlargement appeared to show less rapid suppression of plasma prolactin than five patients without fossa enlargement. At two months this trend was still evident but eventually all patients showed acceptable control of plasma prolactin, with the exception of one patient who required pituitary surgery.Galactorrhoea ceased in 13 of 15 patients, menstrual periods resumed in ten of 13 patients, two patients becoming pregnant first. Potency returned and puberty proceeded in two hypogonadal males. Six of the nine patients requesting treatment for infertility became pregnant. It is concluded that bromocriptine provides effective treatment for galactorrhoea, amenorrhoea or gonadal disorders when there is associated hyperprolactinaem

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1978.tb04521.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

Summary:The problem family and community medicine.The characteristics of problem families are described and especially their dependency upon the social services.They are of increasing importance to community medicine since as shown by the literature their members form 5—10% of the total population and use from 50–80% of the total social and corrective services.The social pathology of 16 root and 110 sub‐families was investigated; enquiries have also been made into the family dynamics and especially child rearing, learning problems and ill health. Infections, injuries and childhood disorders are particularly frequent.There are administrative advantages in regarding these families as socially handic

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1978.tb04522.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

Summary:Association of sick sinus and Lown‐Ganong‐Levine syndromes.A 38‐year‐old woman presented with syncopal attacks for 27 years. The electro‐physiology techniques which enabled the diagnosis of both sinus node dysfunction (sick sinus syndrome) and presence of an atrionodal bypass tract (Lown‐Ganong‐Levine syndrome) ar

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1978.tb04523.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

Summary:Metformin associated lactic acidosis.A case of lactic acidosis occurring in association with inappropriate and excessive metformin therapy and a high serum metformin concentration is described. In the other 23 cases of metformin associated lactic acidosis reported to December 1977, renal, cardiovascular and liver disease were common. Although metformin is less likely to cause lactic acidosis than phenformin, neither drug should be prescribed in the presence of renal, hepatic or cardiovascular disease.

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1978.tb04524.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

Summary:Transient metastatic calcification in primary hyperparathyroidism.Metastatic calcification has been visualised on bone scan in many hypercalcaemic states. This report illustrates the phenomenon occurring in a patient with primary hyperparathyroidism and its subsequent disappearance after therapy.

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1978.tb04525.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY