摘要:

Summary: A. S. D. Spiers, A. G. Baikie, J. A. Dartnall and J. I. Cox, Using a technique of short‐term in vitro culture, cytogenetic studies were performed on splenic tissue from 12 patients with chronic granulocytic leukaemia. In eight patients the disease was in its chronic phase and had been treated with busulphan (seven cases) or splenic irradiation (one case). In five of these patients, small numbers of dividing cells possessing the Philadelphia (Ph1) chromosome were observed; in one, only Phl‐negative meta‐phases, presumably those of lymphocytes, occurred, and in two patients no dividing cells were obtained. In four patients chronic granulocytic leukaemia had undergone metamorphosis to an acute phase: in two of these patients no dividing cells were observed in splenic cultures with or without added phytohaemagglutinin: this result may have been attributable to prior cytotoxic therapy. In cultures from the other two patients in metamorphosis, almost all dividing cells were Phl‐positive and many cells possessed two Ph1chromosomes. Full cytogenetic analysis in one of these cases showed that the spleen contained several closely related cell lines, apparently reflecting progressive tumour cell ev

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1975.tb03262.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

Summary:E. A. Bowie and P. J. Hurley, The effect of oral cobalt chloride on the anaemia of patients undergoing long‐term haemodialysis therapy was investigated in 14 patients taking 25 mg then 50 mg daily. After eight weeks of treatment the mean haematocrit increase in 11 patients completing the trial was 23% of the original level and the51Cr‐red cell volume had increased by 20%. The51Cr red cell half‐life lengthened after treatment in six patients and the59Fe plasma half‐time shortened in ten patients. After treatment, evidence of increased erythropoietic activity was seen in the bone marrow of five patients. No evidence was found of thyroid or liver dysfunction but three patients developed transient loss of hearing demonstrated by audiometry. Cobalt chloride appears to be helpful in the management of some uraemic patients with refractory

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1975.tb03263.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

Summary:This study concerns hepatitis B antigen and antibody, (HBAg and HBAb) auto‐antibodies and liver disease in a renal haemodialysis and transplantation unit between February, 1970 and December, 1972. Fourteen per cent of patients on maintenance haemodialysis, 25% of renal transplant recipients, and 5% of the staff were HBAg positive during this period. Three family members of antigen positive patients developed hepatitis; all were either antigen or antibody positiv

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1975.tb03264.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

Summary:A beneficial clinical effect from the administration of lymphocyte transfer factor is described in six patients with idiopathic early onset chronic muco‐cutaneous candidiasis. Five patients in two families showed a familial disease pattern. Dermal anergy and failure to produce migratory inhibition factor with intact general immune function were found in patients tested. Antifungal chemotherapy was effective in clearing or markedly reducing the candidiasis and remission was maintained by repeated injections of transfer factor. Therapy was monitored using Candida skin tes

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1975.tb03265.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

Summary:The effects of chronic treatment with allopurinol and clofibrate on the elimination from plasma of warfarin and dicoumarol were examined in man. In addition, the binding of warfarin to human serum proteins was measured with and without clofibrate and its metabolite chlorophenoxyisobutyric acid (CPIB), both present in therapeutic concentrations. Treatment with allopurinol and clofibrate did not alter the rate of elimination of warfarin from plasma. In addition, clofibrate and CPIB caused no significant displacement of warfarin from serum proteins. This evidence supports the conclusion that the clinically significant potentiation of warfarin activity by clofibrate in man is due to an interaction at the receptor site. In contrast, treatment with allopurinol resulted in significant prolongation of the plasma half‐life of dicoumarol in one of three subjects. These data are consistent with inhibition of the metabolism of dicoumarol by allopurinol in some individual

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1975.tb03266.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

Summary:A prevalence survey on the island of Karkar had previously shown that chronic lung disease was common in both sexes after the age of 35 years and that, in part, this was related to the smoking of home‐grown air‐cured tobacco. To investigate the nature of this chronic lung disease, 37 non‐tuberculous subjects with reduced ventilatory capacity (forced expiratory volume in one second less than 75% predicted) underwent clinical and lung function investigations. Ninety‐two per cent had adventitiae, 62% had chronic productive cough and 54% had dyspnoea on exertion. Lung function tests showed an irreversible obstructive defect with a variable, but on average, only moderately reduced transfer factor. The chest radiograph showed evidence of hyperinflation in 38% of cases but none had narrowing or loss of pulmonary vessels suggestive of emphysema. “Inflammatory changes” occurred in 35% and were associated with a mild but significant element of restriction. The results suggest that chronic bronchitis and chronic bronchiolitis were the main underlying abnormalities and that emphysema was comparatively unimportant.Asthma appeared to be relatively uncommon, especially in children. The clinical and lung function findings in 16 asthmatics were essentially similar to those observed in asthmatics elsewhere and the atopic status of asthmatics and controls was similar to that observed in developed societies. In common with Highland asthmatics however, the age at onset was in early adult life rather than i

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1975.tb03267.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

Summary: Extensive drug surveillance—A pilot study.D. C. Gerke. E. Gail Easterbrook, D. B. Frewin and T. I. Lee, Aust. N.Z. J. Med., 1975, 5, pp. 336–340. The aim of this Extensive Drug Surveillance programme was to develop a system of drug monitoring suitable for detecting adverse drug reactions in hospitalised patients. The monitored field was a general medical ward in the Royal Adelaide Hospital and monitoring was carried out for a period of one month (September 1974). A total of 85 patients (45 males and 40 females) were monitored and in 14 of them adverse reactions were noted. The overall incidence of such reactions was 16.5%. A greater intake of drugs was a significant finding in patients who experienced adverse reactions. Coupled with this was the observation that patients who stayed longer in hospital had a greater number of drugs administered to them. A third finding was the higher incidence of reactions in female patie

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1975.tb03268.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

Summary:Diarrhoea and colitis associated with antibiotic treatment.G. E. Gibson, R. Rowland and R. Hecker, Aust. N.Z. J. Med., 1975, 5, pp. 340–347. Sixteen cases of colitis developing within twenty‐one days of antibiotic therapy are reported. There was a wide range of disease seventy. Lincomycin and Clindamycin were implicated in twelve. The colitis was of two pathological patterns, pseudomembranous colitis and “non‐specific” colitis. There is a relative sparing of the rectum in some cases making the diagnosis more difficult on sigm

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1975.tb03269.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

Summary:The clinical and pathological features of histiocytic medullary reticulosis (HMR) are described in five patients. Treatment by splenectomy and the MOPP routine resulted in a transient improvement in platelet and neutrophil counts and resolution of anaemia and apparent prolongation of survival in two of the five patients.The relationship of HMR to other histiocytic disorders is discussed. HMR is defined as a unique malignant histiocytosis in which malignant histiocytes engage in phagocytosis of erythrocytes, leucocytes and platelets.

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1975.tb03270.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

Summary:A woman had hypergastrinaemia associated with the variety of gastritis (Type A) that is associated usually with pernicious anaemia, together with recurring bouts of severe abdominal pain. Fasting serum gastrin levels ranged between 600 and 2750 pg/ml. There was a rise in serum gastrin levels after a standard protein meal, indicative of a large G cell mass, and a fall after intragastric HCI, which led to a trial of treatment with HCI; this gave some symptomatic relief. After surgical antrectomy there was a profound fall of serum gastrin from a pre‐operative level of 2500 pg/ml to constant values of 16–25 pg/ml, and complete and lasting relief from the bouts of abdominal p

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1975.tb03271.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY