ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1987.tb00035.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1987.tb00036.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1987.tb00037.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1987.tb00038.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1987.tb00039.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

摘要:

AbstractEnteric coated aspirin was given to eight human volunteers in escalating doses (20, 40,60,80,100 mg daily), each dose being given over two weeks. In addition, to measure the maximum effect of aspirin, each volunteer was given two single doses of 600 mg of soluble aspirin. At the end of each dosing interval we measured platelet aggregation and thromboxane formation in response to four aggregating agents and to whole blood coagulation. The doses of aspirin required to inhibit platelet aggregation in response to various stimuli were: for collagen 60–80 mg, for adenosine diphosphate and adrenaline 60 mg, and for arachidonate 40 mg. For maximum inhibition of thromboxane formation the doses were: for collagen greater than 100 mg, for adenosine diphosphate and adrenaline 60 mg, for arachidonate 80 mg, and for whole blood coagulation 100 mg. Different aspirin doses are required to inhibit the responses to different stimuli. Furthermore, for some stimuli, inhibition of thromboxane generation may require more aspirin than is required for inhibition of aggregation. The clinical implications of these findings are uncertain since we do not know which stimuli are important in arterial thrombosis in ma

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1987.tb00040.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

摘要:

AbstractCirculating immune complexes present in the serum of a patient with systemic lupus erythematosus, end‐stage renal failure, and thoracic vertebralCandida albicansosteomyelitis were sequentially analysed by isoelectric focusing, immunoblotting, and immunoprinting. Candida antigens (including mannoproteins), Clq and C3complement components, and specific anti‐Candida antibody were detected within polyethylene glycol precipitated complexes. An antigen of 47K molecular weight was amongst those demonstrated by polyacrylamide gel electrophoresis to be present within the complexes. It has been proposed elsewhere that a serologic response to a 47K protein is predictive of recovery fromCandida albicansinfection. Free antibody had specificity for Candida antigens ranging in molecular weight from 18K to more, than 100K including a 47K component. The analytical techniques employed allowed rapid and precise identification of the components of one particular immune complex system and will be widely applicable to the dissection of other diverse syst

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1987.tb00041.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1987.tb00042.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

摘要:

AbstractThe progress of five patients with recurrent renal allograft rejection who were treated with anti‐HuLy‐m2 (anti‐T cell subset monoclonal antibody) is described. The therapy was without significant side effects and all patients responded to therapy with a diminution of OKT3+and HuLy‐m1+(= E‐RFC) peripheral blood lymphocytes. Three of the five patients had improvement in renal rejection. One patient demonstrated long term improvement in renal function, in another two patients renal function improved temporarily, and the remaining two patients had no significant benefit from anti‐HuLy‐m2 therapy. This limited trial has demonstrated the potential value of a monoclonal anti‐T cell antibody, reactive with a subset of T cells, for immunotherapy of renal rejection in patients previously treated with anti‐

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1987.tb00043.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1987.tb00044.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY