ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1986.tb02006.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

AbstractControl of immune complex formation is important to limit disease resulting from their deposition in tissues. Any inhibition of immune complex solubilisation is thus significant in the pathogenesis of immune complex diseases. More than half of our patients with various rheumatic connective tissue diseases were demonstrated to have serum inhibition of immune complex solubilisation (12/16 rheumatoid arthritis, 22/37 systemic lupus erythematosus, 16/29 primary Sjogren's syndrome, and eight of nine with mixed connective tissue disease). This serum inhibitory activity did not correlate well with serum levels of IgM rheumatoid factor or circulating immune complexes, and its nature remains to be elucidated. (Aust NZ J Med 1986; 16: 445–451

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1986.tb02007.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

AbstractTo assess the chronicity of symptoms and long term prospects for employment in patients with Reiter's syndrome, a follow‐up study of 111 patients was performed. Ninety‐eight patients were available for follow‐up; these had a mean disease duration of 7.9 years (range two months to 39 years). At follow‐up, 55 patients had symptomatic joints and 26 objective evidence of synovitis, but only seven had chronic joint deformity. Seven patients fulfilled criteria for ankylosing spondylitis. Ninety‐three patients were in functional class I or II, 86 patients were working, 26 had changed employment, and 11 were unemployed because of the disease. No prognostic features of value were identified. The tissue antigen HLA B27 was associated significantly with anterior uveitis and radiological sacroiliitis. (Aust NZ J Med 1986; 16:

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1986.tb02008.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1986.tb02009.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

AbstractThe appearances of the nailfold capillaries can be used to distinguish between various connective tissue diseases. In a study of 30 patients (10 with scleroderma, nine with systemic lupus erythematosus, and 11 with rheumatoid arthritis), photographs were taken of the eight nailfolds of each patient (thumbs excluded) and then coded. Each of the photographs was later analysed by a rheumatology registrar and an attempt was made to predict the patient's diagnosis using only the appearance of the nailfold. The diagnostic specificity and sensitivity were 89% and 80%, respectively.The results indicate that nailfold capillaroscopy, performed by a relatively inexperienced observer, can accurately distinguish between patients with scleroderma and those with systemic lupus erythematosus or rheumatoid arthritis. (Aust NZ J Med 1986; 16: 457–460

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1986.tb02010.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

AbstractBetween March 1981 and March 1985, 76 patients with acute leukemia were treated with cyclophosphamide (120 mg/kg), 12 or 14 Gy total body irradiation, and an HLA‐identical sibling marrow transplant. Forty‐seven patients had acute non‐lymphoblastic leukemia (ANLL) and 29 had acute lymphoblastic leukemia (ALL). Forty‐one were transplanted during first remission and 28 during or after first relapse of their disease. An additional six patients were transplanted because their leukemia was refractory to conventional cytotoxic chemotherapy, and one was transplanted as initial therapy. Actuarial 42 month survival for those transplanted during first remission was 47% and for those transplanted in first relapse or later it was 22% (p = 0.02). There was no difference in either group between those with ANLL and those with ALL. Two of the six patients with refractory leukemia are alive more than 22 and more than 15 months after the transplant. The incidence of acute graft‐versus‐host disease and interstitial pneumonitis was 90% and 39%, respectively, for the first remission group, and 96% and 37% for those transplanted in first relapse or later. There was no significant difference in transplant‐related mortality between the two groups (29% and 43%, respectively). The leukemia recurrence rate, however, was 13% for those transplanted in first remission and 67% for those transplanted in first relapse or later (p = 0.0003). Thus, the major factor determining the incidence of leukemia recurrence and survival after transplant was the status of the leukemia at the time of transplantation. These findings indicate that adults with acute leukemia who have an HLA‐identical sibling should be transplanted in first remission, and that transplant‐related mortality must be reduced urgently. (Aust NZ J Med 1

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1986.tb02011.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

AbstractBetween 1981 and 1985, 27 patients with aplastic anemia have been treated by immunosuppression with antilymphocyte globulin and prednisolone or allogeneic bone marrow transplantation. Fifteen have undergone bone marrow transplantation and have an actuarial survival at 54 months of 65%± 12% (95% confidence limits). There have been four deaths from graft rejection, septicemia (two), and graft‐versus‐host disease. Twelve have received antilymphocyte globulin and have an actuarial survival at 56 months of 67%± 21 %. Five of these now have a normal blood count and two have had good partial responses and are self supporting. Of the five non‐responders, three survived, two with persistent aplasia and one after allogeneic bone marrow transplantation. Two are dead, one of hemorrhage and one after mismatched bone marrow transplantation. In this study antilymphocyte globulin produced survival equivalent to bone marrow transplantation although only 58% of patients had a response to the antilymphocyte globulin. The advantages and disadvantages of these two methods of treatment are discussed. (Aust NZ J Med 1986; 16: 4

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1986.tb02012.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1986.tb02013.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

AbstractThe hypotensive and hormonal effects of the angiotensin converting enzyme (ACE) inhibitor enalapril (10 mg twice daily) were compared with those of hydrochlorothiazide (25 mg twice daily), with the two drugs in combination and with placebo in 21 patients with essential hypertension. For each patient there were four randomised double‐blind treatment phases, each of four weeks' duration, which comprised a 2 times 2 factorial experimen

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1986.tb02014.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

Abstract:There is increasing evidence that only hemodynamically significant internal carotid lesions (of more than 50% diameter stenosis or occlusion) rather than minor lesions are the precursors of stroke. A Doppler test combining periorbital and direct audible interpretation of internal carotid Doppler signals was performed on 67 patients (134 internal carotids) and the results were compared with those from conventional biplane angiography. The test was 100% sensitive and had a positive predictive value of 91% for hemodynamically significant lesions. Negative predictive value for normal or less than 50% stenosis was 100%. Carotid bifurcation bruits were heard over only 25% of internal carotids with significant stenosis and nearly 60% of bruits were heard over internal carotids with minor disease. The equipment was portable and relatively inexpensive. The test could be performed by vascular technicians in less than 12 minutes with minimal patient discomfort, thus meeting most of the criteria for an ideal non‐invasive screening test. (Aust NZ J Med 1986; 16: 481–4

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1986.tb02015.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY