ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1983.tb04647.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1983.tb04648.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

Abstract:Hepatitis B associated delta infection was found in Australian born narcotics users, patients with cirrhosis and hepatoma from Italy and Greece and in south east Asian immigrants. About 9% of patients with chronic hepatitis B were found to have intranuclear delta antigen in liver biopsies with immunofluorescence or anti‐delta antibody in serum by radioimmunoassay. Delta may have been imported from southern Europe and Asia and a reservoir of delta infection may exist in narcotics users. Anti‐delta was not found in hemophiliacs despite exposure to hepatitis B.Delta occurs in Australia and causes acute and particularly chronic hepatitis in addition to that caused by hepatiti

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1983.tb04649.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

Abstract:Primary hepatocellular carcinoma (HCC), is reported in three and probably a fourth member of a New Zealand Chinese family, with a high carrier rate of HBsAg. Hepatitis B virus (HBV) markers and HLA tissue types were analysed in the three generations of the expanded family of 35. Twenty‐one of the three generations were positive for one or more serum HBV markers, including six of the 18 children. Intrafamilial spread of HBV was seen in four of the eight families. Tissue types did not correlate with HBV status. The two propositi of the four with HCC studied and four of six siblings were positive for HBsAg: both propositi had identical HLA haplotypes, including Bw46/DRw9. Evidence is as yet insufficient that this haplotype may represent a disease susceptibility gene for HCC. Other family members at risk will be those positive for HBsAg and/or anti HBC, but those with Bw46/DRw9 will be monitored with special interes

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1983.tb04650.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

Abstract:Serum lipid and apolipoprotein A (apo A) and B (apo B) levels were studied in a family with familial hypercholesterolemia (FH), which comprised two heterozygous parents, five heterozygous children, one homozygote and one normal child. Lipid levels were compared with those of age‐ and sex‐matched normal controls.All subjects with FH had total serum cholesterol and low density lipoprotein‐cholesterol (LDL‐C) levels greater than the 90th percentile value for the reference range. High density lipoprotein‐cholesterol (HDL‐C) levels were less than the corresponding 13th percentile in heterozygous subjects. The homozygous child had grossly elevated levels of LDL‐C and apo B, and very low levels of HDL‐C and apo A.The most powerful discriminating variable between normal, heterozygous and homozygous family members was the LD

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1983.tb04651.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

Abstract:Amiodarone was used in 40 patients with life‐threatening or refractory tachyarrhythmias. Eighteen patients had recurrent ventricular tachycardia of whom 13 had suffered a cardiac arrest. Control has been excellent or good in 17 of these 18 patients during an average follow‐up period of 10 months. A further 22 patients had supraventricular arrhythmias, including three with Wolff‐Parkinson‐White syndrome and paroxysmal atrial fibrillation. In 20 of these control has been excellent or good. The mean daily maintenance dose of amiodarone was 300 mg for patients with ventricular tachyarrhythmias and 200 mg for those with supraventricular tachyarrhythmias. Side‐effects were common and included corneal microdeposits, skin rash and discolouration, alteration in thyroid function, and symptomatic bradycardia. Serious adverse effects were uncommon however and necessitated discontinuation of the drug in only two patients. Amiodarone did not appear to precipitate or exacerbate cardiac failure in any patient although many had severe left ventricular dysfunction. We conclude that amiodarone is effective in the therapy of life‐threatening or refractory cardiac

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1983.tb04652.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

Abstract:Life events reported to have occurred twelve months before the onset of the illness were compared in 55 in‐patients who had a first episode of myocardial infarction and 55 control in‐patients matched for age, sex, marital status and social class and afflicted with acute abdomen, trauma and multiple trauma.The Paykel interview for Recent Life Events was used.Myocardial infarction patients reported significantly more previous events than the control group (p<0.001) with more undesirable (p<0.01) and uncontrolled (p<0.01) events. Moreover, myocardial infarction patients had significantly more events (p<0.01) which had an “objective negative impact” (rated as being traumatic).These findings are consistent with the view that certain recent life events have a positive association with the onset of a first episode of myocardial inf

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1983.tb04653.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

Abstract:Ten patients with Chronic Obstructive Airway Disease (COAD) and five subjects with duodenal ulcers and normal lung function were given 50 mg ranitidine as a single intravenous bolus injection. Hemodynamic responses were continuously monitored. There were no significant alterations in systemic and pulmonary pressures, systemic and total pulmonary vascular resistances or cardiac output. Continuous ECG recordings did not reveal arrhythmias.Ranitidine does not appear to cause any significant disturbance of hemodynamic function in COAD patients. This contrasts with alterations in hemodynamics previously observed following administration of cimetidine.

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1983.tb04654.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

Abstract:Respiratory symptoms and ventilatory function were recorded on 4549 Queensland schoolchildren. Previously parents of 67 children on two occasions showed that key questions on wheezy breathing and productive cough were reliable, with agreement of responses in 97% and 91% of subjects. These two questions divided the children into four main groups: Group A, those children with attacks of asthma or of wheezy breathing; Group B, those with attacks of cough with sputum; Group AB, those with both symptoms; and Group N, those with neither symptom.The validity of the questionnaire was examined by relating question responses to ventilatory function expressed as normalized residuals. Mean (±SD) normalized FEF 25–75 residuals for the major groups were: N, 0 ± 1.00; B, ‐0.10±1.00; A, ‐ 0.26 ±1.10; and AB, ‐0.50±1.07. In subjects with wheeze, residuals distinguished subjects on a basis of frequency of wheeze, total number of attacks, and the association with breathlessness.The proportion of eight year olds in each group (N, B, A and AB) was 44%, 33%, 2.6%, and 20.5% respectively; and of twelve year olds, 52%, 28%, 2.7%, and 18.1%. These results contrast with those of a comparable survey of Tasmanian seven year olds where the proportion was 51%, 33%, 1.8%, and 14.4%

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1983.tb04655.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY

摘要:

Abstract:Two cases of hypertension following renal trauma are reported. In both cases, blood pressure was controlled with captopril, an angiotensin converting enzyme inhibitor. Mechanisms of hypertension following renal trauma are reviewed and the place of medical or surgical management discussed.

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1983.tb04656.x

出版商:Blackwell Publishing Ltd    

年代:1983

数据来源: WILEY