ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1975.tb03634.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

Summary:Mesangial IgA deposition was detected by routine fluorescent microscopy of 19 cases of glomerulonephritis.Twelve patients had a variable degree of diffuse mesangial proliferative glomerulonephritis. The heterogeneous histological findings in the other seven patients show that mesangial IgA deposition alone does not have diagnostic specificity. However, when interpretation of the mesangial IgA deposition is complemented by clinical and histological information, a group of patients with the characteristic combined features can be distinguished.

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1975.tb03635.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

Summary:The relationship of red blood cell (RBC) membrane lipid content to RBC morphology and survival was studied in patients with liver disease. An increase in RBC cholesterol and phospholipid was detected in most patients with hepatocellular disease or cholestatic jaundice but the alteration in RBC lipid content did not correlate with RBC survival. The main abnormality of RBC morphology observed was the presence of macrocytes and target cells. In a small proportion of patients (approximately 3%) with severe hepatocellular disease, significant numbers of severely deformed (“spur”) cells were seen. In these patients haemolysis was moderately severe and the RBC lipid profile showed increased membrane cholesterol without a concomitant increase in phospholipids. It is concluded that only in patients with “spur” cell anaemia do the morphological alterations lead to premature removal of cells from the circulation. The cause of the shortened RBC survival in jaundiced patients without “spur” cells remains to be

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1975.tb03636.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

Summary:So as to test the diagnostic significance of tissue typing in an Australian population the HL‐A antigens of forty‐seven patients with Ankylosing Spondylitis and six patients with Reiter's Syndrome were compared with those found in three hundred and six controls. Since HL‐A W27 was found in 92% of the patients with Ankylosing Spondylitis and all patients with Reiter's Syndrome it is concluded that these diagnoses should be questioned if this antigen cannot be demonstrated. In three family studies it was apparent that Ankylosing Spondylitis only occurred in those who had inherited HL‐A W27 so that the absence of the antigen may help to identify those family members who will not develop the disease. Notwithstanding the association demonstrated the data argue against a close and simple linkage between the antigen and these d

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1975.tb03637.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

Summary:The correlation of clinical features with the operative findings in 14 patients with a floppy mitral valve is discussed.The clinical course is typified by rapidly progressive disability. An abrupt deterioration was present in five of our subjects and this may be due to rupture of chordae tendinea or stretching of the valve apparatus. The redundancy of the anterior cusp in 13 of our series may explain the absence of mid systolic clicks in all except one patient. The diagnosis of prolapse can be difficult to make prior to surgery because the prolapsed cusp may be masked by the regurgitant contrast medium. Hypokinesis and prominent sacculation of the left ventricular inflow tract suggest an associated myocardial abnormality. Calcium was present in one valve and thus mitral valve calcification does not exclude the possibility of a floppy valve in patients with mitral regurgitation.

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1975.tb03638.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

Summary:Aspirin, a drug known to inhibit the platelet release reaction, was evaluated for its potential in reducing platelet/fibrin deposition in hollow fibre dialysers. Twelve patients with end‐stage renal failure were given the drug under controlled conditions while being treated by regular maintenance haemodialysis. After base‐line data were collected during a mean number of 11.7 dialyses per study, observations were repeated for a mean of 9.3 dialyses, during which time each patient took 600 mg of aspirin by mouth every morning. Thrombus deposition, measured by volume loss of the blood compartment of the dialyser fibre bundle, was significantly reduced (P<005) during aspirin administration in six of the 12 studies. The mean volume loss of the fibre bundle in these six studies (responders) was 25% per dialysis during the control period, and 13% with aspirin; in the other six studies (non‐responders), the mean values were 8% and 6% respectively. Aspirin prolonged the bleeding time in all patients, and significantly (P<005) impaired platelet aggregation in both responders and non‐res

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1975.tb03639.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

Summary:The nutritional status of 66 part Aborigines was re‐examined in 1974—with particular reference to blood levels of haemoglobin and vitamins—after white bread fortified with iron and the vitamins B1and PP (niacin) had been available for six and a half months to the population of Bourke, New South Wales. The results found in 1971 and 1974 are compared. A significant improvement from deficient to acceptable blood levels of vitamins B1and B6was found in 44% and 52% of the subjects respectively. This is attributed to the consumption of fortified bread since the levels of the other vitamins had remained either unchanged or worsened. The biochemical improvement in vitamin B6is attributed to the sparing effect of vitamin PP on vitamin B6requirement because the conversion of tryptophan to niacin is impaired in vitamin B6deficiency. Iron deficiency anaemia in children had decreased by 50% but this could have been due to many other factors besides the iron which had been added to the bread. Clinically there was a marked decrease in angular stomatitis and skin xerosis which could be related to the biochemical improvement of the two B‐vitamins and a decrease in active trachoma and suppurative otitis media probably due to intensive treatment received since 1971. The results of this study and the extent of biochemical vitamin B1and B6deficiency found in other groups, indicate that fortification of bread may be of benefit to the community as

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1975.tb03640.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

Summary:Multiple gastric biopsies were performed with a duodenofiberscope in 58 Chinese subjects. All 58 cases had a gastric ulcer crater, demonstrated by endoscopy, or barium meal, or both. Histological sections of the gastric biopsies showed chronic atrophic gastritis in 12 (20.6%), chronic gastritis in 31 (53.4%), and acute‐on‐chronic gastritis in 11 (19%). Only two cases or 3.4% had normal gastric mucosa, while 54 cases or 93% had some form of chronic gastritis, on the gastric biopsy. The gastritis was associated with intestinal metaplasia in 16 cases (27.6%), while two cases had histological evidence of gastric atypia. No significant difference was found in the mean basal and peak acid outputs among the three groups of gastric ulcer cases with chronic atrophic gastritis, chronic gastritis, and acute‐on‐chronic gastritis. The high frequency of chronic gastritis (93%) occurring in patients with gastric ulcer in the present series suggests that chronic gastritis may be an important aetiological factor in the pathogenesis of gastric ulc

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1975.tb03641.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

Summary:A lactulose colonic washout (pH 4.5) was administered to six male patients with portal systemic encephalopathy. Estimation of blood ammonia levels and electroencephalography were performed before and after each treatment. Five patients recorded a significant fall in blood ammonia level as a result of lactulose therapy (P<025). In the sixth subject, an enema with buffered physiological saline, pH 4.5, induced a fall in ammonia which was not increased by subsequent lactulose solution. Improvement in the electroencephalogram was recorded in all periods where a lactulose colonic washout produced a fall in blood ammonia level.

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1975.tb03642.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

Summary:Activities of the small intestinal mucosal enzymes lactase, sucrase, maltase, alkaline phosphatase and N‐acetyl‐β‐glucosaminidase were studied in rats with surgically‐induced upper intestinal stasis and in control animals. The first four are brush border enzymes, the latter a lysosomal enzyme. There was reduction in the activities of all enzymes in the operated animals. This change was significant and most marked in mucosa lining the blind loop and gut distal to it; areas in which there is gross bacterial overgrowth and excessive levels of intraluminal deconjugated bile salts. The significance of these findings in relation to malabsorption consequent on bacterial contamination of the upper gut is uncertain and requires furth

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1975.tb03643.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY