ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1979.tb04310.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1979.tb04311.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1979.tb04312.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1979.tb04313.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1979.tb04314.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

Summary:The solid phase Clq radioimmunoassay was used to detect immune complexes in sera from patients with systemic lupus erythematosus (14/25), rheumatoid arthritis (4/5), vasculitis (5/15), infective endocarditis (2/2), acute rheumatic fever (2/3), pre‐eclamptic toxaemia (0/14), lung cancer (3/7), glomerulonephritis (26/98) and renal transplant patients (0/5). The best correlation with disease activity was seen in systemic lupus erythematosus and infective endocarditis where serial immune complex determinations were clearly of value in monitoring therapy. The findings in primary glomerulonephritis indicate only a limited usefulness of the assay in that serum immune complexes were detected in a minority (22/73) of patients with glomerular immune deposits. In particular the data do not support a role for Clq fixing immune complexes in the pathogenesis of membranous glomerulonephritis or in pre‐eclamptic toxae

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1979.tb04315.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

Summary:The hyperlipoproteinaemia accompanying chronic renal failure and renal transplantation has been re‐examined in terms of the apoprotein (apo A and apo B) moieties of the high density (HDL) and low density (LDL) lipoproteins. Hypertriglyceridaemia is prevalent in chronic uraemia and is not corrected by haemodialysis or renal transplantation. Hypercholesterolaemia is characteristic only of renal allograft recipients. Apo A levels are reduced in undialyzed uraemics and remain low during haemodialysis, as well as in patients with renal allografts of less than six months duration. In renal transplant recipients of greater than one year duration, apo A levels are normalized. The normalization of apo A level is related to the stability of graft function, as determined by sequential analysis of 15 renal transplant recipients. Apo B levels are normal in uraemic and dialyzed patients, but are elevated in long term transplant recipients. Unlike apo A levels, this alteration does not appear to reflect the restoration of kidney functio

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1979.tb04316.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

Summary:The concentrations of 5‐fluorouracil in tears and plasma were studied in eight patients receiving the drug for carcinoma of the colon. The drug was measured by a gas liquid chromatographic method and found to be present only in the tears of patients with excessive lacrimation.In three patients with watery eyes the peak concentration in tears (16–23.8 μg/ml) occurred 15 minutes after IV administration and this corresponded with the end of the distribution (α) phase in the plasma when the plasma levels ranged from 18–26 μg/ml. In five patients without eye symptoms the drug was undetectable in the lacrimal fluid even though they had similar plasma levels (15–25 μg/ml) of 5‐fluorouracil. The volumes of distribution and plasma clearance rates were similar in the two groups [being 0.2–0.52 (mean =0.33) 1/kg and 612–978 (mean = 850) mllmin respectively in patients with excessive lacrimation and 0.13–0.79 (mean = 0.36) 1/kg and 435–1138 (mean = 831) mllmin respectively in the five patients without symptoms.].It appears that 5‐fluorouracil produces irritation of the lacrimal apparatus in about 30% of patients on the drug and in association with this appears in the tears where it may be responsible for the reported irritation and fi

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1979.tb04317.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

Summary:One‐hundred‐and‐twenty‐two patients with Crohn's disease were admitted to Royal Prince Alfred Hospital from 1966 to 1977. Thirty‐seven had disease confined to small bowel, 37 to colon and 48 had combined small and large bowel involvement. The disease was twice as common in females as in males. Pain was the major symptom in patients with small bowel disease and was associated with diarrhoea if both small and large bowel were involved. Disease confined to the colon most commonly produced diarrhoea with bleeding. Perianal disease occurred more often in patients with colonic disease. Systemic complications were also more frequent in the group with disease confined to colon, and these complications were often multiple. Medical treatment with corticosteroids, salazopyrine or azathioprine, was generally unsuccessful. One in two patients required surgery, usually in the form of resection. Following resection, recurrence occurred in more than one half of the patients but was less frequent in those with colonic disease. Three‐quarters of patients with a recurrence required a further resection, emphasising the unsatisfactory long‐term results of surgery in

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1979.tb04318.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY

摘要:

Summary:Infusion of 0.1 M HCI (0.5 mmol/kg/hr over 20 minutes) into the duodenum of each of seven normal subjects led to a significant rise (P<0.05) in mean plasma secretin levels from 3.0±2.2 (SE) to 15±4.0 pmol/l. Intravenous infusion of secretin at a rate of 6–6 pmol/kg/hr (0.08 clinical units/kg/hr) reproduced the peak plasma levels of secretin observed during duodenal acidification. However, there was no detectable (2.5 pmol/l) change in plasma secretin after oral protein or gluc

ISSN:0004-8291    

DOI:10.1111/j.1445-5994.1979.tb04319.x

出版商:Blackwell Publishing Ltd    

年代:1979

数据来源: WILEY