ISSN:0736-8046    

DOI:10.1111/j.1525-1470.1996.tb01411.x

出版商:Blackwell Publishing Ltd    

年代:1996

数据来源: WILEY

摘要:

Abstract:Lichen striatus is a self‐limiting inflammatory condition of unknown etiology in which the lesions follow the lines of Blaschko. We report a series of 61 cases of this condition in children, describing the clinical features, age distribution, and season of onset. The preponderance of cases in the preschool‐age group and onset in the spring and summer months support the hypothesis of an environmental agent, possibly an infection, in the etiology of the condit

ISSN:0736-8046    

DOI:10.1111/j.1525-1470.1996.tb01412.x

出版商:Blackwell Publishing Ltd    

年代:1996

数据来源: WILEY

摘要:

Abstract:We observed 2 families with 26 individuals affected by multiple lentigines syndrome (MLS). All patients had extensive generalized lentigines, including in the axillary and inguinal regions, diffuse hyperpigmentation, hypopigmented patches, and hyperpigmented patches, many of which appeared clinically to be café au lait spots. Multiple lentigines syndrome should be considered in the differential diagnosis of multiple café au lait spots in children, particularly since the spots are usually present before the lentigines develop and may be clinically indistinguishable from the café au lait spots of neurofibromatosis. No significant non‐cutaneous features occurred in the two families with three generations of affected individuals, suggesting that MLS is a distinct entity. However, patients with the noncutaneous abnormalities of the LEOPARD syndrome have been described in families in which most members had pigmentary lesions only. Therefore, patients with multiple lentigines should be evaluated for noncutaneous abnormalities, particularly hearing loss and cardiac anomalies. Similarly, until investigators demonstrate lack of genetic linkage between MLS and LEOPARD syndrome, genetic counseling of patients affected by the cutaneous features of the former should include the potential for noncutaneous features in offsp

ISSN:0736-8046    

DOI:10.1111/j.1525-1470.1996.tb01413.x

出版商:Blackwell Publishing Ltd    

年代:1996

数据来源: WILEY

摘要:

Abstract:The so‐called KID (keratitis, ichthyosis, deafness) syndrome is a congenital disorder of ectoderm that affects not only the epidermis, but also other ectodermal tissues such as the corneal epithelium and the inner ear. Sixty‐one patients who fulfill the criteria for this syndrome were identified in a review of the literature through December 1993. All had cutaneous and auditory abnormalities, and 95% also had ophthalmologic defects. The most frequent clinical features were neurosensory deafness 90%, erythrokeratoderma 89%, vascularizing keratitis 79%, alopecia 79%, and reticulated hyperkeratosis of the palms and soles 41%. All of these findings constitute the major criteria for the diagnosis. The KID acronym does not accurately define this entity since the disorder is not an ichthyosis, because scaling is not the main cutaneous feature and not all patients have keratitis early in the course. We suggest that this syndrome should be included under the general heading of congenital ectodermal defects as a keratodermatous ectodermal dysplasia (K

ISSN:0736-8046    

DOI:10.1111/j.1525-1470.1996.tb01414.x

出版商:Blackwell Publishing Ltd    

年代:1996

数据来源: WILEY

摘要:

Abstract:Calcinosis cutis, an uncommon disorder characterized by hydroxyapatite crystals of calcium phosphate deposited in the skin, has been described infrequently in childhood. Classically, it is divided into dystrophic, metastatic, and idiopathic types. We report an 8‐year‐old girl with hyperphosphatemia secondary to a tumor lysis syndrome, who developed a localized soft tissue calcification over a previous lesion of ec‐thyma gangrenosum. Intravenous infusion of calcium gluconate was probably the precipitating factor. Our case illustrates that several etio‐pathogenic mechanisms may be simultaneously involved in calcinosi

ISSN:0736-8046    

DOI:10.1111/j.1525-1470.1996.tb01415.x

出版商:Blackwell Publishing Ltd    

年代:1996

数据来源: WILEY

摘要:

Abstract:A 7‐year‐old boy with T cell acute lymphoblastic leukemia developed disseminated hyalohyphomycosis due toFusarium solani.The clinical features included fever, severe myalgia, documented fungemia withF. solani, an ecthyma gangrenosum‐like lesion next to a peripheral venous catheter, and disseminated pustules. Severe neutropenia due to chemotherapy was the most revelant risk factor. Histopathologic study of the ecthyma gangrenosum‐like lesion, as well as pustular lesions, revealed epidermal necrosis and an inflammatory infiltrate in the upper dermis, with numerous septate hyphae demonstrated by periodic acid‐Schiff stain. Clinical resolution was achieved with granulocyte colony‐stimulating factor and amphotericin B administration. Our case suggests that the peripheral venous access was probably the portal of entry of

ISSN:0736-8046    

DOI:10.1111/j.1525-1470.1996.tb01416.x

出版商:Blackwell Publishing Ltd    

年代:1996

数据来源: WILEY

摘要:

Abstract:Juvenile xanthogranuloma and urticaria pigmentosa are well described in the dermatologic literature. We recently observed a 9‐month‐old boy with the two diseases occurring concomitantly. This rare combination is described and a brief review of the literature is gi

ISSN:0736-8046    

DOI:10.1111/j.1525-1470.1996.tb01417.x

出版商:Blackwell Publishing Ltd    

年代:1996

数据来源: WILEY

摘要:

Abstract:We report a 16‐year‐old Hispanic girl with gastrointestinal complaints and an unusual cutaneous eruption consisting of vesiculopustules and blanching erythematous plaques with peripheral scale. Diagnostic workup showed collections of neutrophils in the upper epidermis and subcorneal layer on the skin biopsy specimen, and deep ulcerations, crypt abscesses, and granulomas on endoscopy, diagnostic of Crohn disease. The skin findings are consistent with a vesiculopustular eruption without vasculitis, previously only reported in association with ulcerative colitis. This case broadens the spectrum of neutrophilbased cutaneous disorders associated with inflammatory bowel disease. Clinicians should be aware of the usual cutaneous manifestations of inflammatory bowel disease and consider the diagnosis of Crohn disease in the context of vesiculopustular dermatitis and abdominal symptomatol

ISSN:0736-8046    

DOI:10.1111/j.1525-1470.1996.tb01418.x

出版商:Blackwell Publishing Ltd    

年代:1996

数据来源: WILEY

摘要:

Abstract:A case of childhood granulomatous periorificial dermatitis is described. This disorder occurs predominantly in prepubertal black children and is characterized by a monomorphous, papular eruption occurring around the mouth, nose, and eyes. It is benign and self‐limited. Treatment may include topical metronidazole in young patients and tetra‐cycline in those over 8 years of

ISSN:0736-8046    

DOI:10.1111/j.1525-1470.1996.tb01419.x

出版商:Blackwell Publishing Ltd    

年代:1996

数据来源: WILEY

摘要:

Abstract:The study of hair follicle tumors can be confusing, and hair follicle nevi are no exception. Analogous lesions frequently have divergent appellations. We evaluated the English‐language literature on hair follicle nevi and histologic equivalents from 1921 to 1994. In addition, we reviewed four standard dermatopathology textbooks for further examples. We found 20 published valid cases of hair follicle nevi. Two of the cases were called congenital vellus hamartoma. Hair follicle nevi are rare, benign, often congenital hamartomas composed of multiple vellus hairs. They are typically on the face. We present an infant girl with a hair follicle nevus and review the histologic features and nomenclature of the lesio

ISSN:0736-8046    

DOI:10.1111/j.1525-1470.1996.tb01420.x

出版商:Blackwell Publishing Ltd    

年代:1996

数据来源: WILEY