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1. |
Histopathology and Immunofluorescence of Discoid Lupus Erythematosus in Children |
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Pediatric Dermatology,
Volume 13,
Issue 4,
1996,
Page 269-273
Pierre M. George,
Antoinette F. Hood,
Ellen B. Rest,
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摘要:
Abstract:The histopathology and immunofluorescence of discoid lupus erythematosus (DLE) are well documented In adults, but in children they have not been studied systematically. We reviewed nine skin biopsy specimens from six children with DLE. Only three specimens showed the well‐developed epidermal changes seen in lesions of adults with DLE, and in the other six, these changes were either mild or absent. All nine specimens showed some degree of vacuolar alteration of the basal layer, ranging from focal and mild to severe. They all had a moderate to heavy lymphocytic dermal infiltrate in a perivascular and periadnexal distribution. Direct immunofluorescence performed on five specimens of lesional skin was weakly positive for IgM or IgG in three cases, negative in one, and strongly positive for IgM, IgG, IgA, and C3 in one. This study indicates that the range of histologic and immunofluorescence features in children with DLE is similar to that in adults. The histologic findings are distinctive enough to be useful in establishing the diagnosis, although clinico‐pathologic correlation is requi
ISSN:0736-8046
DOI:10.1111/j.1525-1470.1996.tb01236.x
出版商:Blackwell Publishing Ltd
年代:1996
数据来源: WILEY
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2. |
Idiopathic Eruptive Macular Pigmentation: Report of Five Patients |
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Pediatric Dermatology,
Volume 13,
Issue 4,
1996,
Page 274-277
C. Sanz De Galdeano,
C. Léauté‐Labrèze,
P. Bioulac‐Sage,
M. Nikolic,
A. Taïeb,
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摘要:
Abstract:We report the occurrence of idiopathic eruptive macular pigmentation in four children and one adolescent. This condition appears to be a distinct clinicopathologic and histologic entity. It is characterized by asymptomatic, pigmented macules involving the neck, trunk, and proximal limbs. All patients or their families denied the patients' having taken any drug before the eruption. In all of the patients the first sign was a pigmented spot without preceding erythematous, papular, or hypopigmented lesions. Histologic study showed enhanced epidermal basal layer pigmentation with pigmentary incontinence, a mild perivascular lympho‐histiocytic infiltrate, and many melanophages in the papillary dermis. Electron microscopy showed an increased number of melanosomes in basal and suprabasal keratinocytes as well as clustered melanosomes in dermal melanophages. Treatment of this asymptomatic condition is unnecessary because spontaneous resolution of the lesions is to be expected within several months to a few year
ISSN:0736-8046
DOI:10.1111/j.1525-1470.1996.tb01237.x
出版商:Blackwell Publishing Ltd
年代:1996
数据来源: WILEY
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3. |
Periauricular Eczematization in Childhood Atopic Dermatitis |
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Pediatric Dermatology,
Volume 13,
Issue 4,
1996,
Page 278-280
Kyu Han Kim,
Ji Hwan Hwang,
Kyoung Chan Park,
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摘要:
Abstract:We investigated the prevalence of periauricular eczematization (PAE) in children with atopic dermatitis (AD) in Korea, and evaluated the clinical significance of the lesion in terms of Its treatment in relation to a possible pathogenetic role forStaphylococcus aureus.Tentatively, PAE was classified as infraauricular and postauricular fissuring, which were observed in 62 (57,9%) and 37 (34.6%) of 107 patients, respectively. Sixty eight patients (64.5%) had infraauricular or postauricular fissures, or both, and this prevalence was significantly (p<0.01) higher than that in controls (1.3%).Staphylococcusaureus was cultured from oozing material from infraauricular fissures in 12 of 14 patients, and topical application of erythromycin cream to the ear lesions led to faster and more definite improvement. Our study shows that PAE is a characteristic clinical manifestation of AD, probably induced by S. aureus. Topical antibiotics are worth trying for effective management of this disorder.
ISSN:0736-8046
DOI:10.1111/j.1525-1470.1996.tb01238.x
出版商:Blackwell Publishing Ltd
年代:1996
数据来源: WILEY
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4. |
Aerobic and Anaerobic Microbiology of Necrotizing Fasciitis in Children |
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Pediatric Dermatology,
Volume 13,
Issue 4,
1996,
Page 281-284
Itzhak Brook,
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摘要:
Abstract:Specimens obtained from eight children with necrotizing fasciitis (NF) were cultured for aerobic and anaerobic bacteria. A total of 21 isolates were recovered, 13 anaerobic and 8 aerobic or facultatives. The facultative organism Streptococcuspyogeneswas present alone in two (25%) instances, and mixed aerobic and anaerobic bacteria were isolated in six (75%). The predominant isolates werePeptostreptococcusspp. (6 isolates, including 3 Peptostreptococcusmagnus). S.pyogenes(4),Bacteroides fragilisgroup (3),Clostridium perfringens(2),Escherichia coli(2), andPrevotellaspp. (2). Organisms similar to the ones isolated from the NF aspirates were recovered in the blood of all patients except one. These included S.pyogenes(3 isolates).B. fragilisgroup (2),E. coli(1), andP. magnus(1) andClostridium perfringens(1). All patients underwent surgical fasciotomy, and four required skin grafting. Antimicrobials were administered to all children. Despite extensive resection and intense supportive therapy, three patients died from sepsis accompanied by shock acidosis and disseminated intravascular coagulation. These findings illustrate the polymicrobial aerobic‐anaerobic flora of NF in childre
ISSN:0736-8046
DOI:10.1111/j.1525-1470.1996.tb01239.x
出版商:Blackwell Publishing Ltd
年代:1996
数据来源: WILEY
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5. |
Amelanotic Spitzoid Melanoma in the Burn Scar of a Child |
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Pediatric Dermatology,
Volume 13,
Issue 4,
1996,
Page 285-287
Zahra Ghorbani,
Yahya Dowlati,
Amir H. Mehregan,
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摘要:
Abstract:We report a 3‐year‐old girl with a rapidly growing, amelanotic, nodular melanoma developing within a burn scar over the dorsal aspect of the left foot. Histologically, the lesion was spindle cell and exhibited lack of maturation, cellular atypia, and scattered mitotic figures. Twenty five percent of the tumor cells were positive for proliferating cell nuclear antigen by immunohistochemical stain. A left inguinal lymph node was also positive for regional metastasis. The child died with disseminated metastases 13 months after the lesion was remo
ISSN:0736-8046
DOI:10.1111/j.1525-1470.1996.tb01240.x
出版商:Blackwell Publishing Ltd
年代:1996
数据来源: WILEY
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6. |
Pachydermodactyly in Two Young Girls |
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Pediatric Dermatology,
Volume 13,
Issue 4,
1996,
Page 288-291
Federico Bardazzi,
Iria Neri,
Pier Alessandro Fanti,
Annalisa Patrizi,
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摘要:
Abstract:Pachydermodactyly is a benign, superficial fibromatosis frequently observed in young males. We describe the condition in two young girls affected by Ehlers‐Danlos syndrome (EDS) and tuberous sclerosis, respectively. We hypothesized that in the patient with tuberous sclerosis, pachydermodactyly is a clinical manifestation of the associated systemic disease, whereas obsessive‐compulsive behavior is probably the main cause in the girl with
ISSN:0736-8046
DOI:10.1111/j.1525-1470.1996.tb01241.x
出版商:Blackwell Publishing Ltd
年代:1996
数据来源: WILEY
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7. |
Staphylococcal Blistering Dactylitis: Report of Two Patients |
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Pediatric Dermatology,
Volume 13,
Issue 4,
1996,
Page 292-293
Alejandro Woroszylski,
Carola Durán,
Lourdes Tamayo,
Ma. Luz Orozco,
Ramon Ruiz‐Maldonado,
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摘要:
Abstract:Two children with staphylococcal blistering distal dactylitis (BDD), a condition usually caused by streptococci, are reported. Etiologic distinction in BDD can be made only bacteriologically. Staphylococci are increasingly the cause of bacterial cutaneous infections.
ISSN:0736-8046
DOI:10.1111/j.1525-1470.1996.tb01242.x
出版商:Blackwell Publishing Ltd
年代:1996
数据来源: WILEY
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8. |
Fox‐Fordyce Disease in Two Prepubertal Girls: Histopathologic Demonstration of Eecrine Sweat Gland Involvement |
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Pediatric Dermatology,
Volume 13,
Issue 4,
1996,
Page 294-297
Maria Ranalletta,
Alicia Rositto,
Ricardo Drut,
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摘要:
Abstract:This report presents two prepubertal girls with Fox‐Fordyce disease, The pruritic papules extensively affected the areas where apocrine glands are distributed (axillae, periareolar and Jntermammary zones, pubes, Infraumbilical midline), and also extended to the neck and face near the external angle of the eyes in one child. Analyses of several biopsy specimens showed that the main lesion was a spongiotic vesicle containing inflammatory ceils and keratlnocytes affecting the hair in‐fundibuia and acrosyringia, together, with hyperkeratosis of both adnexa, The cause of the disease remains elusive, but the microscopic findings may explain the good results obtained with keratolytic age
ISSN:0736-8046
DOI:10.1111/j.1525-1470.1996.tb01243.x
出版商:Blackwell Publishing Ltd
年代:1996
数据来源: WILEY
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9. |
Neonatal Lupus Erythematosus in an Infant with Turner Syndrome |
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Pediatric Dermatology,
Volume 13,
Issue 4,
1996,
Page 298-302
E. Ruas,
A. Moreno,
O. Tellechea,
G. Rocha,
A. Poires Raptista,
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摘要:
Abstract:Neonatal lupus erythematosus (NLE) is characterized by transient, annular cutaneous lesions, congenital heart block, and a variety of systemic or hematologic abnormalities. We describe a white infant girt with onset of skin lesions on the face and scalp at 4 days of age. At age 4 weeks she had generalized, erythematous, scaly, annular skin lesions that underwent spontaneous regression at age 5 months. Her mother had no cutaneous or other lesions, but complement examinations revealed the presence of anti‐Ro(SSA) and anti‐La(SSB) antibodies, and absence of anti‐Sm and anti‐RNP antibodies. Karyotyping revealed Turner syndrome (TS) with 45,XO sex chromosome constitution. Ro(SSA) and La(SSB) antibodies were found, and direct immunofluorescence testing on healthy skin was positive. At age 5 months, follow‐up immunologic examination of the infant had normal results but the mother still had anti‐Ro(SSA) and anti‐La(SSB) antibodies. We believe that this is the first reported case of NLE in associ
ISSN:0736-8046
DOI:10.1111/j.1525-1470.1996.tb01244.x
出版商:Blackwell Publishing Ltd
年代:1996
数据来源: WILEY
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10. |
A New Case of Hairy Elbows Syndrome (Hypertrichosis Cubiti) |
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Pediatric Dermatology,
Volume 13,
Issue 4,
1996,
Page 303-305
Pilar Escalonilla,
Antonio Aguilar,
Miguel Gallego,
Enric Piqué,
M. Carmen Fariña,
Luis Requena,
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摘要:
Abstract:Hypertrichosis cubiti, also named hairy elbows syndrome (HES), is an uncommon variety of congenital, circumscribed hypertrichosis in which a remarkable amount of long vellus hair is localized on the extensor surfaces of the upper extremities. Usually, this condition appears in infancy, increases during early childhood, and regresses spontaneously at puberty. The mode of inheritance is not elucidated, and the condition presents in a sporadic or familial form. In most patients HES is not associated with any other physical abnormalities, although short stature and other developmental disorders have been described in some. An 8‐year‐old girl affected with HES is reported. The literature on this subject is reviewed, and some clinical and etiopathogenic aspects are discus
ISSN:0736-8046
DOI:10.1111/j.1525-1470.1996.tb01245.x
出版商:Blackwell Publishing Ltd
年代:1996
数据来源: WILEY
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